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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Potential Phytoconstituents of Genus Vitex for the Management of Rheumatoid Arthritis: A Review

Author(s): Upasana Thakur* and Mahendra Singh Ashawat

Volume 19, Issue 2, 2023

Published on: 21 October, 2022

Page: [134 - 150] Pages: 17

DOI: 10.2174/1573397118666220919120722

Price: $65

Abstract

Rheumatoid arthritis is one of the most predominant conditions which have utmost influence on the society. The disease is an inflammatory disorder which affects joints, connective tissues, muscles, tendons and fibrous tissues. Approximately 270 known species of vitex genus are known, extending from shrubs to trees in the tropical, sub-tropical regions and temperate zones. Several species of vitex have been used traditionally over world-wide. The main focus of the present study is to review various phytoconstituents isolated from the genus vitex which can be used for the treatment of rheumatic disorders. The study also covers the underlying targets of the phytoconstituents which can be possible potential hits for the management of Rheumatic disorders.

Keywords: Vitex, rheumatic disorders, autoimmune disease, anti-inflammatory, phytoconstituents, management

Graphical Abstract

[1]
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS. The American rheumatism association. 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31(3): 315-24.
[2]
Chandrasekar R, Chandrasekar S. Natural herbal treatment for rheumatoid arthritis -a review. Int J Pharma Sci 2017; 8(2): 368-84.
[3]
Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet 2001; 358(9285): 903-11.
[http://dx.doi.org/10.1016/S0140-6736(01)06075-5] [PMID: 11567728]
[4]
Gordon DA, Stein JL, Broder I. The extra-articular features of rheumatoid arthritis. Am J Med 1973; 54(4): 445-52.
[http://dx.doi.org/10.1016/0002-9343(73)90040-5] [PMID: 4348718]
[5]
Turesson C, Jacobsson L, Bergström U. Extra-articular rheumatoid arthritis: Prevalence and mortality. Br J Rheumatol 1999; 38(7): 668-74.
[http://dx.doi.org/10.1093/rheumatology/38.7.668] [PMID: 10461483]
[6]
Almoallim H, Al Saleh J, Badsha H, et al. A review of the prevalence and unmet needs in the management of rheumatoid arthritis in Africa and the Middle East. Rheumatol Ther 2021; 8(1): 1-16.
[http://dx.doi.org/10.1007/s40744-020-00252-1] [PMID: 33226566]
[7]
Macfarlane GJ, Paudyal P, Doherty M, et al. A systematic review of evidence for the effectiveness of practitioner-based complementary and alternative therapies in the management of rheumatic diseases: Rheumatoid arthritis. Rheumatology 2012; 51(9): 1707-13.
[http://dx.doi.org/10.1093/rheumatology/kes133] [PMID: 22661556]
[8]
Nordström DC. DNA synthesis in CD4- and CD8-positive cells in synovial fluid of patients with reactive and rheumatoid arthritis. Rheumatol Int 1989; 8(6): 269-72.
[http://dx.doi.org/10.1007/BF00270983] [PMID: 2499030]
[9]
Nouri AM, Panayi GS, Goodman SM. Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol 1984; 55(2): 295-302.
[PMID: 6607791]
[10]
Saxne T, Palladino MA Jr, Heinegãrd D, Talal N, Wollheim FA. Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum 1988; 31(8): 1041-5.
[http://dx.doi.org/10.1002/art.1780310816] [PMID: 3136775]
[11]
Di Giovine FS, Nuki G, Duff GW. Tumour necrosis factor in synovial exudates. Ann Rheum Dis 1988; 47(9): 768-72.
[http://dx.doi.org/10.1136/ard.47.9.768] [PMID: 3263088]
[12]
Mannik M, Nardella FA, Sasso EH. Rheumatoid factors in immune complexes of patients with rheumatoid arthritis. Springer Semin Immunopathol 1988; 10(2-3): 215-30.
[http://dx.doi.org/10.1007/BF01857226] [PMID: 3055378]
[13]
Carson DA, Pasquali JL, Tsoukas CD, et al. Physiology and pathology of rheumatoid factors. Springer Semin Immunopathol 1981; 4(2): 161-79.
[http://dx.doi.org/10.1007/BF01857093] [PMID: 7323953]
[14]
Soltys AJ, Axford JS, Sutton BJ. Rheumatoid factors: Where are we now? Ann Rheum Dis 1997; 56(5): 285-6.
[http://dx.doi.org/10.1136/ard.56.5.285] [PMID: 9175927]
[15]
Edwards JCW, Blades S, Cambridge G. Restricted expression of FcγRIII (CD16) in synovium and dermis: Implications for tissue targeting in rheumatoid arthritis (RA). Clin Exp Immunol 2003; 108(3): 401-6.
[http://dx.doi.org/10.1046/j.1365-2249.1997.3941286.x] [PMID: 9182883]
[16]
Sayah A, English JC III. Rheumatoid arthritis: A review of the cutaneous manifestations. J Am Acad Dermatol 2005; 53(2): 191-209.
[http://dx.doi.org/10.1016/j.jaad.2004.07.023] [PMID: 16021111]
[17]
Ahuja SC, Ahuja S, Ahuja U. Nirgundi (Vitexnegundo) - Nature’s gift to mankind. Asian Agrihist 2015; 19(1): 5-32.
[18]
Chantaranothai R. A revision of the genus Vitex (Lamiaceae) in Thailand. Trop Nat Hist 2011; 11(2): 91-118.
[19]
Meena AK, Singh U, Yadav AK, Singh B, Rao MM. Pharmacological and phytochemical evidences for the extracts from plants of the Genus vitex - a review. Int J Pharm Clin Res 2010; 1-9.
[20]
Meena AK, Niranjan US, Rao MM, Padhi MM, Babu R. A review of the important chemical constituents and medicinal uses of Vitex genus. Asian J Tradit Med 2011; 6: 54-60.
[21]
Rani A, Sharma A. The genus Vitex: A review. Pharmacogn Rev 2013; 7(14): 188-98.
[http://dx.doi.org/10.4103/0973-7847.120522] [PMID: 24347927]
[22]
Perry LM. Medicinal plants of East and Southeast Asia. Attributed properties. Massachusetts Institute of Technology Press, Cambridge, Massachusetts. Econ Bot 1980; 34: 361.
[23]
Vishwanathan AS, Basavaraju R. A review on Vitexnegundo L. - A medicinally important plant. Eur J Biol Sci 2010; 3(1): 30-42.
[24]
Tarafdar CR. Ethnobotanical observations on Nishinda. Folklore 1983; 24(8): 170-4.
[25]
Tarafdar CR. Ethnobotany of ChhotaNagpur. Folklore 1986; 27(6): 119-24.
[26]
Tarafdar CR. Some traditional knowledge about tribal health. Folklore 1987; 28(2): 37-42.
[27]
Tarafdar CR, Raichaudhuri HN. Less known medicinal plants among the tribals of Hazaribagh district of Bihar. Contributions to Ethnobotany of India. Jodhpur, India: Scientific Publishers 1991; pp. 91-100.
[28]
Hegde GR, Hebbar SS. Ethno medico-botany in Karnataka-Dharwad district. In: Krishnan S, Bhat DJ, Eds. Plant and Fungal Biodiversity and Bioprospecting. Panjim, Goa, India: Broadway Book Centre 2009; pp. 64-81.
[29]
Purohit S, Vyas S. Medicinal plant cultivation: a scientific approach. India: Published by Agrobios 2004; p. 624.
[30]
Basavaraju R, Raj JV, Bhiravamurthy PV. Medicinal plant resources of puttaparthimandal: Taxonomic overview and need for conservation. Ethnobot leafl 2009; 13: 1382-400.
[31]
Purkayastha J, Nath SC, Islam M. Ethnobotany of medicinal plants from Dibru-Saikhowa Biosphere Reserve of Northeast India. Fitoterapia 2005; 76(1): 121-7.
[http://dx.doi.org/10.1016/j.fitote.2004.10.012] [PMID: 15664476]
[32]
Saikia AP, Ryakala VK, Sharma P, Goswami P, Bora U. Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. J Ethnopharmacol 2006; 106(2): 149-57.
[http://dx.doi.org/10.1016/j.jep.2005.11.033] [PMID: 16473486]
[33]
Kotoky J, Das PN. Medicinal plants used for liver diseases in some parts of Kamrup district of Assam, a North Eastern State of India. Fitoterapia 2008; 79(5): 384-7.
[http://dx.doi.org/10.1016/j.fitote.2008.02.003] [PMID: 18502053]
[34]
Sharma PK, Chauhan NS, Lal B. Observations on the traditional phytotherapy among the inhabitants of Parvati valley in western Himalaya, India. J Ethnopharmacol 2004; 92(2-3): 167-76.
[http://dx.doi.org/10.1016/j.jep.2003.12.018] [PMID: 15137998]
[35]
Hebbar SS, Harsha VH, Shripathi V, Hegde GR. Ethnomedicine of Dharwad district in Karnataka, India—plants used in oral health care. J Ethnopharmacol 2004; 94(2-3): 261-6.
[http://dx.doi.org/10.1016/j.jep.2004.04.021] [PMID: 15325728]
[36]
Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the Siddis of Uttara Kannada district, Karnataka, India. J Ethnopharmacol 1995; 47(3): 149-58.
[http://dx.doi.org/10.1016/0378-8741(95)01274-H] [PMID: 8569239]
[37]
Jagtap SD, Deokule SS, Bhosle SV. Some unique ethnomedicinal uses of plants used by the Korku tribe of Amravati district of Maharashtra, India. J Ethnopharmacol 2006; 107(3): 463-9.
[http://dx.doi.org/10.1016/j.jep.2006.04.002] [PMID: 16713158]
[38]
Pattanaik C, Sudhakar Reddy C, Murthy MSR. An ethnobotanical survey of medicinal plants used by the Didayi tribe of Malkangiri district of Orissa, India. Fitoterapia 2008; 79(1): 67-71.
[http://dx.doi.org/10.1016/j.fitote.2007.07.015] [PMID: 17855018]
[39]
Samy RP, Thwin MM, Gopalakrishnakone P, Ignacimuthu S. Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India. J Ethnopharmacol 2008; 115(2): 302-12.
[http://dx.doi.org/10.1016/j.jep.2007.10.006] [PMID: 18055146]
[40]
Ignacimuthu S, Ayyanar M, Sivaraman KS. Ethnobotanical investigations among tribes in Madurai District of Tamil Nadu (India). J Ethnobiol Ethnomed 2006; 2(1): 25-31.
[http://dx.doi.org/10.1186/1746-4269-2-25] [PMID: 16689985]
[41]
Muthu C, Ayyanar M, Raja N, Ignacimuthu S. Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India. J Ethnobiol Ethnomed 2006; 2(1): 43-52.
[http://dx.doi.org/10.1186/1746-4269-2-43] [PMID: 17026769]
[42]
Rajadurai M, Vidhya V, Ramya M, Bhaskar A. Ethno-medicinal plants used by the traditional healers of Pachamalai hills, Tamilnadu, India. Ethnomedicine 2009; 3: 39-41.
[43]
Jain SP, Puri HS. Ethnomedicinal plants of Jaunsar-Bawar hills, Uttar Pradesh, India. J Ethnopharmacol 1984; 12(2): 213-22.
[http://dx.doi.org/10.1016/0378-8741(84)90049-7] [PMID: 6521494]
[44]
Tran QTN, Wong WSF, Chai CLL, Christina LL. Labdane diterpenoids as potential anti-inflammatory agents. Pharmacol Res 2017; 124: 43-63.
[http://dx.doi.org/10.1016/j.phrs.2017.07.019] [PMID: 28751221]
[45]
Gersch M, Kreuzer J, Sieber SA. Electrophilic natural products and their biological targets. Nat Prod Rep 2012; 29(6): 659-82.
[http://dx.doi.org/10.1039/c2np20012k] [PMID: 22504336]
[46]
Bremner P, Heinrich M. Natural products as targeted modulators of the nuclear factor- κ B pathway. J Pharm Pharmacol 2010; 54(4): 453-72.
[http://dx.doi.org/10.1211/0022357021778637] [PMID: 11999122]
[47]
Zheng CJ, Lan XP, Wang Y, et al. A new labdane diterpene from Vitex negundo. Pharm Biol 2012; 50(6): 687-90.
[http://dx.doi.org/10.3109/13880209.2011.597410] [PMID: 22486582]
[48]
Li CZ, Su YF, Ji XJ. Advances in studies on chemical constituents from plants of Vitex L. and their bioactivities. Chin Tradit Herbal Drugs 2005; 36: 930-8.
[49]
Kimura T, But PPH, Guo JX, Sung CK. International collation of traditional and folk medicine. (1st ed.), World Scientific Publishing Company 1997.
[http://dx.doi.org/10.1142/3041]
[50]
Bensky D, Gamble A. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press 1986; pp. 44-5.
[51]
Sohn SH, Ko E, Oh BG, et al. Inhibition effects of Vitex rotundifolia on inflammatory gene expression in A549 human epithelial cells. Ann Allergy Asthma Immunol 2009; 103(2): 152-9.
[http://dx.doi.org/10.1016/S1081-1206(10)60169-X] [PMID: 19739429]
[52]
Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. J Nat Prod 2002; 65(4): 537-41.
[http://dx.doi.org/10.1021/np0105331] [PMID: 11975496]
[53]
Hu Y, Xin HL, Zhang QY, Zheng HC, Rahman K, Qin LP. Anti-nociceptive and anti-hyperprolactinemia activities of Fructus viticis and its effective fractions and chemical constituents. Phytomedicine 2007; 14(10): 668-74.
[http://dx.doi.org/10.1016/j.phymed.2007.01.008] [PMID: 17350238]
[54]
Kawazoe K, Yutani A, Tamemoto K, et al. Phenylnaphthalene compounds from the subterranean part of Vitex rotundifolia and their antibacterial activity against methicillin-resistant Staphylococcus aureus. J Nat Prod 2001; 64(5): 588-91.
[http://dx.doi.org/10.1021/np000307b] [PMID: 11374949]
[55]
Kawazoe K, Yutani A, Takaishi Y. Aryl naphthalenes norlignans from Vitex rotundifolia. Phytochemistry 1999; 52(8): 1657-9.
[http://dx.doi.org/10.1016/S0031-9422(99)00405-7]
[56]
Ono M, Yamamoto M, Masuoka C, Ito Y, Yamashita M, Nohara T. Diterpenes from the fruits of Vitex rotundifolia. J Nat Prod 1999; 62(11): 1532-7.
[http://dx.doi.org/10.1021/np990204x] [PMID: 10579867]
[57]
Ono M, Yamamoto M, Yanaka T, Ito Y, Nohara T. Ten new labdane-type diterpenes from the fruit of Vitex rotundifolia. Chem Pharm Bull 2001; 49(1): 82-6.
[http://dx.doi.org/10.1248/cpb.49.82] [PMID: 11201231]
[58]
Kondo Y, Sugiyama K, Nozoe S. Studies on the constituents of Vitex rotundifolia L. fil. Chem Pharm Bull 1986; 34(11): 4829-32.
[http://dx.doi.org/10.1248/cpb.34.4829] [PMID: 3829197]
[59]
Lee C, Lee JW, Jin Q, et al. Anti-inflammatory constituents from the fruits of Vitex rotundifolia. Bioorg Med Chem Lett 2013; 23(21): 6010-4.
[http://dx.doi.org/10.1016/j.bmcl.2013.08.004] [PMID: 24035341]
[60]
Iwueke AV, Nwodo OFC, Okoli CO. Evaluation of the anti-inflammatory and analgesic activities of Vitexdoniana leaves. Afr J Biotechnol 2006; 5: 1929-35.
[61]
Irvine FR. Woody plants of Ghana. Oxford University Press 1961; pp. 761-2.
[62]
Kokwaro JO. Medicinal plants of East Africa. (3rd ed.). University of Nairobi Press 2009; p. 152.
[63]
Abdulrahma FI, Onyeyili PA, Sandabe UK, Ogugbuaja VO. Evaluation of the effects of the aqueous extract of Vitexdoniana root-bark on the peripheral and central nervous system of laboratory animals. J Appl Sci 2007; 7(10): 1397-403.
[http://dx.doi.org/10.3923/jas.2007.1397.1403]
[64]
Olusola L, Zebulon SC, Okoye FU. Effects of Vitexdoniana stem bark on blood pressure. Niger J Nat Prod Med 1997; 1: 19-20.
[65]
Tijjani MA, Abdurahaman FI, Khan IZ, Sandabe UK. Anti-inflammatory, anticonvulsant and antipyretic properties of ethanol extracts of Vitexdonianasweet stem bark. Int Res J Pharm 2012; 3: 288-92.
[66]
Charles OO, Ismail OI, Sylvia A, et al. Phytoecdysteroids from the Stem Bark of Vitexdoniana and their anti-inflammatory effects. Planta Med 2013; 79(01): 52-9.
[PMID: 23150078]
[67]
Zhang SF, Dong QF, Hu C, Hao Y, Qu L, Lian JF. Chemical composition of flower volatile oil of wild Vitex negundo var. Heterophylla. Chin J Exp Tradit Med 2013; 19: 151-3.
[68]
Xie JC, Shun BG, Wang XB. Preparation, analysis and flavouring of essential oil of Vitex negundo L. var. heterophylla (Franch.) Rehd. Food Res Dev 2006; 18: 89-93.
[69]
Zhou Y, Zhai Y, He R, Qiu F, Kurihare H. Effect of Vitex negundo var. heterophylla seeds ethanol extract (VSE) on mice model of immunological hepatitis and acute inflammation. Zhongguo Zhongyao Zazhi 2011; 36(17): 2404-8.
[PMID: 22121812]
[70]
Xu LM, Hao ML, Fan P, Luo L. Preliminary study on herbicidal activities of extract of Vitex negundo var. heterophylla and other seven plants. Pesticides 2011; 50: 8.
[71]
Huang HC, Chang TY, Chang LZ, et al. Inhibition of melanogenesis versus antioxidant properties of essential oil extracted from leaves of Vitex negundo Linn and chemical composition analysis by GC-MS. Molecules 2012; 17(4): 3902-16.
[http://dx.doi.org/10.3390/molecules17043902] [PMID: 22466851]
[72]
Li SH, Zhang HJ, Qiu SX, et al. Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus. Tetrahedron Lett 2002; 43(29): 5131-4.
[http://dx.doi.org/10.1016/S0040-4039(02)00981-4]
[73]
Lou ZH, Li HM, Gao LH, Li RT. Antioxidant lignans from the seeds of Vitex negundo var. cannabifolia. J Asian Nat Prod Res 2014; 16(9): 963-9.
[http://dx.doi.org/10.1080/10286020.2014.929574] [PMID: 24965780]
[74]
Hu P, Li DH, Hu X, et al. Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation. Fitoterapia 2016; 111: 147-53.
[http://dx.doi.org/10.1016/j.fitote.2016.04.020] [PMID: 27118321]
[75]
Zheng CJ, Zhang XW, Han T, et al. Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds. Fitoterapia 2014; 93: 31-8.
[http://dx.doi.org/10.1016/j.fitote.2013.12.006] [PMID: 24369311]
[76]
Xiu-Fang N, Li-Li Y, et al. Two new lignans from the aerial part of Vitex negundo. J Asian Nat Prod Res 2016; 18(7): 656-61.
[77]
Ye H, Guo-Yu D, Ping H. Vitex negheteroin M, a new phenolic glycoside from Vitex negundo var. heterophylla. Nat Prod Res 2019; 35(9): 1518-24.
[http://dx.doi.org/10.1080/14786419.2019.1656628] [PMID: 31411058]
[78]
Kumar M, Rawat P, Dixit P, et al. Anti-osteoporotic constituents from Indian medicinal plants. Phytomedicine 2010; 17(13): 993-9.
[http://dx.doi.org/10.1016/j.phymed.2010.03.014] [PMID: 20554183]
[79]
Shraddha D, Mayuri K, Anilkumar A, Sonali G, Radhika P. LUTEOLIN- phytoconstituents responsible for anti-inflammatory activity in leaves of vitexnegundo linn. (Lamiaceae). Curr Trends Pharm Pharm Chem 2020; 2(4): 45-50.
[80]
Pandey A, Bani S, Satti NK, Gupta BD, Suri KA. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res 2012; 61(4): 293-304.
[http://dx.doi.org/10.1007/s00011-011-0410-x] [PMID: 22228102]
[81]
Nasir E, Ali S I. “Flora of Pakistan,” National Herbarium, NARC, Islamabad, Department of Botany, University of Karachi, Karachi, (Fascicles) 1972-94.
[82]
Sastri BN. The Wealth of India-A Dictionary of Raw Material and Industrial Products. Publication and information directorate. CSIR New Delhi 1950; 5: 285-93.
[83]
Hartung T. Growing 101 Herbs That Heal. North Adams, MA: Storey Publishing 2000.
[84]
Chevallier A. Encyclopedia of Herbal Medicine. New York: Dorling Kindersley 2000.
[85]
Okuyama E, Fujimori S, Yamazaki M, Deyama T. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull 1998; 46(4): 655-62.
[http://dx.doi.org/10.1248/cpb.46.655] [PMID: 9579042]
[86]
You KM, Jong HG, Kim HP. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch Pharm Res 1999; 22(1): 18-24.
[http://dx.doi.org/10.1007/BF02976430] [PMID: 10071954]
[87]
Ko WG, Kang TH, Lee SJ, et al. Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 2000; 38(10): 861-5.
[http://dx.doi.org/10.1016/S0278-6915(00)00079-X] [PMID: 11039319]
[88]
Ono M, Ito Y, Nohara T. A labdane diterpene glycoside from fruit of Vitex rotundifolia. Phytochemistry 1998; 48(1): 207-9.
[http://dx.doi.org/10.1016/S0031-9422(97)00863-7]
[89]
Ahmad B, Azam S, Bashir S, Khan I, Adhikari A, Choudhary MI. Anti-inflammatory and enzyme inhibitory activities of a crude extract and a pterocarpan isolated from the aerial parts of Vitex agnus-castus. Biotechnol J 2010; 5(11): 1207-15.
[http://dx.doi.org/10.1002/biot.201000020] [PMID: 21058321]
[90]
Rasul A, Zhao BJ, Liu J, et al. Molecular mechanisms of casticin action: An update on its antitumor functions. Asian Pac J Cancer Prev 2014; 15(21): 9049-58.
[http://dx.doi.org/10.7314/APJCP.2014.15.21.9049] [PMID: 25422178]
[91]
Chan E W C, Wong S K, Chan H T. Casticin from Vitex species: A short review on its anticancer and anti-inflammatory properties. J Integr Med 2017; 0338.
[92]
Ye L, Yan S. Casticin attenuates rheumatoid arthritis through PKC-NF-κB signaling in-vitro and in-vivo. Int J Clin Exp Pathol 2016; 9(3): 2879-87.
[93]
Zeng X, Fang Z, Wu Y, Zhang H. Chemical constituents of the fruits of Vitextrifolia 1996; 21(3): 167-8.
[94]
Yoshioka T, Inokuchi T, Fujioka S, Kimura Y. Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z Naturforsch C J Biosci 2004; 59(7-8): 509-14.
[http://dx.doi.org/10.1515/znc-2004-7-810] [PMID: 15813370]
[95]
Chen HY, Cheng WX, Feng Y, Gu K, Yang LJ, Zhang YP. Studies on flavonoid constituents of Vitextrifolia L. var. simplicifolia Cham. Nat Prod Res 2008; 20(4): 582-4.
[96]
Kim H, Yi JM, Kim NS, et al. Cytotoxic compounds from the fruits of Vitex rotundifolia against human cancer cell lines. J Korean Soc Appl Biol Chem 2012; 55(3): 433-7.
[http://dx.doi.org/10.1007/s13765-012-2027-3]
[97]
Meier B, Berger D, Hoberg E, Sticher O, Schaffner W. Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine 2000; 7(5): 373-81.
[http://dx.doi.org/10.1016/S0944-7113(00)80058-6] [PMID: 11081988]
[98]
Kikuchi H, Yuan B, Nishimura Y, et al. Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. Int J Oncol 2013; 43(6): 1976-84.
[http://dx.doi.org/10.3892/ijo.2013.2133] [PMID: 24126491]
[99]
Choudhary MI, Azizuddin , Jalil S, et al. Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. Phytother Res 2009; 23(9): 1336-9.
[http://dx.doi.org/10.1002/ptr.2639] [PMID: 19173281]
[100]
Mesaik MA, Azizuddin , Murad S, et al. Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. Phytother Res 2009; 23(11): 1516-20.
[http://dx.doi.org/10.1002/ptr.2492] [PMID: 19441009]
[101]
Belic I, Bergant-Dolar J, Morton RA. Constituents of Vitexagnus-castus seeds. Part I. casticin. J Chem Soc 1961; 73: 2523-5.
[http://dx.doi.org/10.1039/jr9610002523]
[102]
Díaz F, Chávez D, Lee D, et al. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod 2003; 66(6): 865-7.
[http://dx.doi.org/10.1021/np0300784] [PMID: 12828478]
[103]
Roy SK, Bairwa K, Grover J, Srivastava A, Jachak SM. Analysis of flavonoids and iridoids in Vitex negundo by HPLC-PDA and method validation. Nat Prod Commun 2013; 8(9): 1934578X1300800.
[http://dx.doi.org/10.1177/1934578X1300800914] [PMID: 24273856]
[104]
Liou CJ, Len WB, Wu SJ, Lin CF, Wu XL, Huang WC. Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages. J Ethnopharmacol 2014; 158(Pt A): 310-6.
[http://dx.doi.org/10.1016/j.jep.2014.10.046] [PMID: 25446583]
[105]
Ahmad B, Azam S, Bashir S, Adhikari A, Iqbal CM. Biological activities of a new compound isolated from the aerial parts of Vitexagnus-castus L. Afr J Biotechnol 2010; 9(53)
[106]
Hu P, Li DH, Jia CC, et al. Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities. J Funct Foods 2017; 35: 236-44.
[http://dx.doi.org/10.1016/j.jff.2017.05.047]
[107]
Vinuchakkaravarthy T, Kumaravel KP, Ravichandran S, Velmurugan D. Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory phospholipase A2 through molecular docking. Bioinformation 2011; 7(4): 199-206.
[http://dx.doi.org/10.6026/97320630007199] [PMID: 22102777]
[108]
Chawla AS, Sharma AK, Handa SS, Dhar KL. Chemical investigation and anti-inflammatory activity of Vitex negundo seeds. J Nat Prod 1992; 55(2): 163-7.
[http://dx.doi.org/10.1021/np50080a002] [PMID: 1624939]
[109]
Khan A, Naz S, Farooq U, et al. Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation. J Pain Res 2017; 11: 95-102.
[http://dx.doi.org/10.2147/JPR.S145551] [PMID: 29343985]

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