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Current Vascular Pharmacology

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ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

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Review Article

Patients with Polyvascular Disease: A Very High-risk Group

Author(s): Antonis A. Manolis, Theodora A. Manolis and Antonis S. Manolis*

Volume 20, Issue 6, 2022

Published on: 25 October, 2022

Page: [475 - 490] Pages: 16

DOI: 10.2174/1570161120666220912103321

Price: $65

Abstract

Polyvascular disease (PolyvascDis) with atherosclerosis occurring in >2 vascular beds (coronary, carotid, aortic, visceral and/or peripheral arteries) is encountered in 15-30% of patients who experience greater rates of major adverse cardiovascular (CV) events. Every patient with multiple CV risk factors or presenting with CV disease in one arterial bed should be assessed for PolyvascDis clinically and noninvasively prior to invasive angiography. Peripheral arterial disease (PAD) can be readily diagnosed in routine practice by measuring the ankle-brachial index. Carotid disease can be diagnosed by duplex ultrasound showing % stenosis and/or presence of plaques. Coronary artery disease (CAD) can be screened by determining coronary artery calcium score using coronary computed tomography angiography; further, non-invasive testing includes exercise stress and/or myocardial perfusion imaging or dobutamine stress test, prior to coronary angiography. Abdominal ultrasound can reveal an abdominal aortic aneurysm. Computed tomography angiography will be needed in patients with suspected mesenteric ischemia to assess the mesenteric arteries. Patients with the acute coronary syndrome and concomitant other arterial diseases have more extensive CAD and poorer CV outcomes. Similarly, PolyvascDis in patients with carotid disease and/or other PAD is independently associated with an increased risk for all-cause and CV mortality during long-term follow-up. Treatment of patients with PolyvascDis should include aggressive management of all modifiable risk factors by lifestyle changes and drug therapy, with particular attention to patients who are commonly undertreated, such as those with PAD. Revascularization should be reserved for symptomatic vascular beds, using the least aggressive strategy in a multidisciplinary vascular team approach.

Keywords: polyvascular disease, coronary artery disease, peripheral artery disease, carotid disease, abdominal aortic aneurysm, atherosclerosis, cardiovascular outcomes, major adverse cardiovascular events

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Graphical Abstract

[1]
Yakubov S. Polyvascular atherosclerotic disease: Recognizing the risks and managing the syndrome. Curr Med Res Opin 2009; 25(11): 2631-41.
[http://dx.doi.org/10.1185/03007990903223895] [PMID: 19769467]
[2]
Weissler EH, Jones WS, Desormais I, et al. Polyvascular disease: A narrative review of current evidence and a consideration of the role of antithrombotic therapy. Atherosclerosis 2020; 315: 10-7.
[http://dx.doi.org/10.1016/j.atherosclerosis.2020.11.001] [PMID: 33190107]
[3]
Aboyans V, Ricco JB, Bartelink MLEL, et al. 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in col-laboration with the European Society for Vascular Surgery (ESVS). Eur Heart J 2018; 39(9): 763-816.
[http://dx.doi.org/10.1093/eurheartj/ehx095] [PMID: 28886620]
[4]
Zhang Q, Wang A, Zhang S, et al. Asymptomatic polyvascular disease and the risks of cardiovascular events and all-cause death. Atherosclerosis 2017; 262: 1-7.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.015] [PMID: 28463782]
[5]
Savji N, Rockman CB, Skolnick AH, et al. Association between advanced age and vascular disease in different arterial territories: A popu-lation database of over 3.6 million subjects. J Am Coll Cardiol 2013; 61(16): 1736-43.
[http://dx.doi.org/10.1016/j.jacc.2013.01.054] [PMID: 23500290]
[6]
Samsky MD, Mentz RJ, Stebbins A, et al. Polyvascular disease and increased risk of cardiovascular events in patients with type 2 diabe-tes: Insights from the EXSCEL trial. Atherosclerosis 2021; 338: 1-6.
[http://dx.doi.org/10.1016/j.atherosclerosis.2021.10.011] [PMID: 34741929]
[7]
Vlajinac HD, Marinković JM, Maksimović MZ, Radak DJ, Arsić RB, Jorga JB. The prevalence of polyvascular disease in patients with carotid artery disease and peripheral artery disease. Kardiol Pol 2019; 77(10): 926-34.
[http://dx.doi.org/10.33963/KP.14945] [PMID: 31456586]
[8]
Chunawala ZS, Qamar A, Arora S, et al. Prevalence and prognostic significance of polyvascular disease in patients hospitalized with acute decompensated heart failure: The ARIC study. J Card Fail 2022; S1071-9164(22): 00005-7.
[http://dx.doi.org/10.1016/j.cardfail.2022.01.002]
[9]
Kobo O, Contractor T, Mohamed MO, et al. Impact of pre-existent vascular and poly-vascular disease on acute myocardial infarction management and outcomes: An analysis of 2 million patients from the national inpatient sample. Int J Cardiol 2021; 327: 1-8.
[http://dx.doi.org/10.1016/j.ijcard.2020.11.051] [PMID: 33271206]
[10]
Vidakovic R, Schouten O, Kuiper R, et al. The prevalence of polyvascular disease in patients referred for peripheral arterial disease. Eur J Vasc Endovasc Surg 2009; 38(4): 435-40.
[http://dx.doi.org/10.1016/j.ejvs.2009.05.006] [PMID: 19560948]
[11]
van Kuijk JP, Flu WJ, Chonchol M, et al. The prevalence and prognostic implications of polyvascular atherosclerotic disease in patients with chronic kidney disease. Nephrol Dial Transplant 2010; 25(6): 1882-8.
[http://dx.doi.org/10.1093/ndt/gfp756] [PMID: 20061315]
[12]
Despotovic N, Erceg P, Brajovic M, Sekularac N, Milosevic D, Davidovic M. Progression of polyvascular disease-is there any rule? Adv Gerontol 2008; 21(3): 420-3.
[PMID: 19432176]
[13]
Van Damme H, Creemers E, Dekoster G, Legrand M, Albert A, Limet R. Polyvascular patients. Retrospective study of 4200 vascular pa-tients operated on between 1980 and 1986. Acta Chir Belg 1988; 88(2): 111-9.
[PMID: 3260433]
[14]
Bhatt DL, Steg PG, Ohman EM, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006; 295(2): 180-9.
[http://dx.doi.org/10.1001/jama.295.2.180] [PMID: 16403930]
[15]
Dilic M, Dzubur A, Kusljugic Z, Balic S, Pepic E. Correlation of arterial hypertension and type 2 diabetes mellitus with type of polyvascu-lar atherosclerotic disease. Med Arh 2010; 64(5): 264-8.
[PMID: 21287949]
[16]
Hirata A, Kishida K, Nakatsuji H, Hiuge-Shimizu A, Funahashi T, Shimomura I. Metabolic syndrome correlates with polyvascular lesions detected by systemic vascular ultrasonography in Japanese people with type 2 diabetes. Diabetes Res Clin Pract 2012; 96(2): e26-9.
[http://dx.doi.org/10.1016/j.diabres.2012.01.020] [PMID: 22325158]
[17]
Melita H, Manolis AA, Manolis TA, Manolis AS. Lipoprotein(a) and cardiovascular disease: a missing link for premature atherosclerotic heart disease and/or residual risk. J Cardiovasc Pharmacol 2022; 79(1): e18-35.
[http://dx.doi.org/10.1097/FJC.0000000000001160] [PMID: 34694242]
[18]
Tmoyan NA, Afanasieva OI, Ezhov MV, Klesareva EA, Balakhonova TV, Pokrovsky SN. Lipoprotein(a), immunity, and inflammation in polyvascular atherosclerotic disease. J Cardiovasc Dev Dis 2021; 8(2): 11.
[http://dx.doi.org/10.3390/jcdd8020011] [PMID: 33513851]
[19]
Song P, Seok JM, Kim WS, Lee YT, Kim DK, Kim GM. Increased lipoprotein(a) is associated with polyvascular disease in patients under-going coronary artery bypass graft. Atherosclerosis 2011; 219(1): 285-90.
[http://dx.doi.org/10.1016/j.atherosclerosis.2011.05.039] [PMID: 21708382]
[20]
Al Thani H, El-Menyar A, AlHabib KF, et al. Polyvascular disease in patients presenting with acute coronary syndrome: Its predictors and outcomes. ScientificWorldJournal 2012; 2012: 1-7.
[http://dx.doi.org/10.1100/2012/284851] [PMID: 22272171]
[21]
Dikilitas O, Satterfield BA, Kullo IJ. Risk factors for polyvascular involvement in patients with peripheral artery disease: A mendelian randomization study. J Am Heart Assoc 2020; 9(24): e017740.
[http://dx.doi.org/10.1161/JAHA.120.017740] [PMID: 33287626]
[22]
Bosevski M, Kostoska S, Tosev S, Borozanov V. Usefulness of D-Dimers and fibrinogen plasma determination in patients with polyvas-cular disease. Angiol Sosud Khir 2006; 12(2): 9-15.
[PMID: 17053757]
[23]
Sabouret P, Cacoub P, Dallongeville J, et al. REACH: International prospective observational registry in patients at risk of atherothrombot-ic events Results for the French arm at baseline and one year. Arch Cardiovasc Dis 2008; 101(2): 81-8.
[http://dx.doi.org/10.1016/S1875-2136(08)70263-8] [PMID: 18398391]
[24]
Eagle KA, Hirsch AT, Califf RM, et al. Cardiovascular ischemic event rates in outpatients with symptomatic atherothrombosis or risk factors in the united states: Insights from the REACH Registry. Crit Pathw Cardiol 2009; 8(2): 91-7.
[http://dx.doi.org/10.1097/HPC.0b013e3181a84613] [PMID: 19417637]
[25]
Suárez C, Zeymer U, Limbourg T, et al. Influence of polyvascular disease on cardiovascular event rates. Vasc Med 2010; 15(4): 259-65.
[http://dx.doi.org/10.1177/1358863X10373299] [PMID: 20724374]
[26]
Bhatt DL, Peterson ED, Harrington RA, et al. Prior polyvascular disease: Risk factor for adverse ischaemic outcomes in acute coronary syndromes. Eur Heart J 2009; 30(10): 1195-202.
[http://dx.doi.org/10.1093/eurheartj/ehp099] [PMID: 19339264]
[27]
Maddox TM, Stanislawski MA, Grunwald GK, et al. Nonobstructive coronary artery disease and risk of myocardial infarction. JAMA 2014; 312(17): 1754-63.
[http://dx.doi.org/10.1001/jama.2014.14681] [PMID: 25369489]
[28]
Neglia D, Rovai D, Caselli C, et al. Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Circ Cardiovasc Imaging 2015; 8(3): e002179.
[http://dx.doi.org/10.1161/CIRCIMAGING.114.002179] [PMID: 25711274]
[29]
Przewłocki T, Kabłak-Ziembicka A, Kozanecki A, et al. Polyvascular extracoronary atherosclerotic disease in patients with coronary ar-tery disease. Kardiol Pol 2009; 67(8A): 978-84.
[PMID: 19784902]
[30]
Imori Y, Akasaka T, Ochiai T, et al. Co-existence of carotid artery disease, renal artery stenosis, and lower extremity peripheral arterial disease in patients with coronary artery disease. Am J Cardiol 2014; 113(1): 30-5.
[http://dx.doi.org/10.1016/j.amjcard.2013.09.015] [PMID: 24157190]
[31]
Collet JP, Cayla G, Ennezat PV, et al. Systematic detection of polyvascular disease combined with aggressive secondary prevention in patients presenting with severe coronary artery disease: The randomized AMERICA Study. Int J Cardiol 2018; 254: 36-42.
[http://dx.doi.org/10.1016/j.ijcard.2017.11.081] [PMID: 29407124]
[32]
Ferreira-González I, Permanyer Miralda G, Heras M, et al. Prognosis and management of patients with acute coronary syndrome and pol-yvascular disease. Rev Esp Cardiol 2009; 62(9): 1012-21.
[PMID: 19712622]
[33]
Hussein AA, Uno K, Wolski K, et al. Peripheral arterial disease and progression of coronary atherosclerosis. J Am Coll Cardiol 2011; 57(10): 1220-5.
[http://dx.doi.org/10.1016/j.jacc.2010.10.034] [PMID: 21371639]
[34]
Meizels A, Zeitoun DM, Bataille V, et al. Impact of polyvascular disease on baseline characteristics, management and mortality in acute myocardial infarction. The Alliance project. Arch Cardiovasc Dis 2010; 103(4): 207-14.
[http://dx.doi.org/10.1016/j.acvd.2010.02.002] [PMID: 20656631]
[35]
Subherwal S, Bhatt DL, Li S, et al. Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Qual Outcomes 2012; 5(4): 541-9.
[http://dx.doi.org/10.1161/CIRCOUTCOMES.111.964379] [PMID: 22715460]
[36]
Miura T, Soga Y, Doijiri T, et al. Prevalence and clinical outcome of polyvascular atherosclerotic disease in patients undergoing coronary intervention. Circ J 2013; 77(1): 89-95.
[http://dx.doi.org/10.1253/circj.CJ-12-0535] [PMID: 23018634]
[37]
van der Meer MG, Cramer MJ, van der Graaf Y, Appelman Y, Doevendans PA, Nathoe HM. The impact of polyvascular disease on long-term outcome in percutaneous coronary intervention patients. Eur J Clin Invest 2014; 44(3): 231-9.
[http://dx.doi.org/10.1111/eci.12222] [PMID: 24372467]
[38]
Morikami Y, Natsuaki M, Morimoto T, et al. Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revas-cularization: An observation from the CREDO-Kyoto Registry Cohort-2. Atherosclerosis 2013; 228(2): 426-31.
[http://dx.doi.org/10.1016/j.atherosclerosis.2013.04.005] [PMID: 23623262]
[39]
Fujisue K, Tokitsu T, Yamamoto E, et al. Prognostic significance of polyvascular disease in heart failure with preserved left ventricular ejection fraction. Medicine 2019; 98(28): e15959.
[http://dx.doi.org/10.1097/MD.0000000000015959] [PMID: 31305390]
[40]
Nie J, Hou L, Tan B. Correlation between carotid stenosis degree and blood pressure variability in patients with carotid stenosis. Comput Math Methods Med 2022; 2022: 1-10.
[http://dx.doi.org/10.1155/2022/4305015] [PMID: 35637843]
[41]
Nardi V, Benson J, Bois MC, et al. Carotid plaques from symptomatic patients with mild stenosis is associated with intraplaque hemor-rhage. Hypertension 2022; 79(1): 271-82.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.18128] [PMID: 34878895]
[42]
Chambers BR, Norris JW. Outcome in patients with asymptomatic neck bruits. N Engl J Med 1986; 315(14): 860-5.
[http://dx.doi.org/10.1056/NEJM198610023151404] [PMID: 3528855]
[43]
Hertzer NR, Young JR, Beven EG, et al. Coronary angiography in 506 patients with extracranial cerebrovascular disease. Arch Intern Med 1985; 145(5): 849-52.
[http://dx.doi.org/10.1001/archinte.1985.00360050105017] [PMID: 3994461]
[44]
Steinvil A, Sadeh B, Arbel Y, et al. Prevalence and predictors of concomitant carotid and coronary artery atherosclerotic disease. J Am Coll Cardiol 2011; 57(7): 779-83.
[http://dx.doi.org/10.1016/j.jacc.2010.09.047] [PMID: 21310312]
[45]
Barnes RW, Liebman PR, Marszalek PB, Kirk CL, Goldman MH. The natural history of asymptomatic carotid disease in patients undergo-ing cardiovascular surgery. Surgery 1981; 90(6): 1075-83.
[PMID: 7313942]
[46]
Giannopoulos A, Kakkos S, Abbott A, et al. Long-term mortality in patients with asymptomatic carotid stenosis: Implications for statin therapy. Eur J Vasc Endovasc Surg 2015; 50(5): 573-82.
[http://dx.doi.org/10.1016/j.ejvs.2015.06.115] [PMID: 26299982]
[47]
Blanco M, Sobrino T, Montaner J, et al. Stroke with polyvascular atherothrombotic disease. Atherosclerosis 2010; 208(2): 587-92.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.041] [PMID: 19695570]
[48]
Meng X, Chen Y, Jing J, et al. Association between polyvascular atherosclerosis and estimated glomerular filtration rate in patients with ischaemic stroke: Data analysis of the patients in the Chinese National Stroke Registry. Neurol Res 2015; 37(5): 415-20.
[http://dx.doi.org/10.1179/1743132815Y.0000000029] [PMID: 25896168]
[49]
Calvet D, Touzé E, Varenne O, Sablayrolles JL, Weber S, Mas JL. Prevalence of asymptomatic coronary artery disease in ischemic stroke patients: The PRECORIS study. Circulation 2010; 121(14): 1623-9.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.109.906958] [PMID: 20351236]
[50]
Hofmann R, Kypta A, Steinwender C, Kerschner K, Grund M, Leisch F. Coronary angiography in patients undergoing carotid artery stent-ing shows a high incidence of significant coronary artery disease. Heart 2005; 91(11): 1438-41.
[http://dx.doi.org/10.1136/hrt.2004.050906] [PMID: 15761052]
[51]
Paraskevas KI, Mikhailidis DP, Liapis CD. Internal carotid artery occlusion: Association with atherosclerotic disease in other arterial beds and vascular risk factors. Angiology 2007; 58(3): 329-35.
[http://dx.doi.org/10.1177/0003319707301754] [PMID: 17626988]
[52]
Sirimarco G, Amarenco P, Labreuche J, et al. Carotid atherosclerosis and risk of subsequent coronary event in outpatients with athero-thrombosis. Stroke 2013; 44(2): 373-9.
[http://dx.doi.org/10.1161/STROKEAHA.112.673129] [PMID: 23306325]
[53]
Manzano L, Mostaza JM, Suarez C, et al. Prognostic value of the ankle-brachial index in elderly patients with a stable chronic cardiovas-cular event. J Thromb Haemost 2010; 8(6): 1176-84.
[http://dx.doi.org/10.1111/j.1538-7836.2010.03841.x] [PMID: 20230414]
[54]
Hur DJ, Kizilgul M, Aung WW, Roussillon KC, Keeley EC. Frequency of coronary artery disease in patients undergoing peripheral artery disease surgery. Am J Cardiol 2012; 110(5): 736-40.
[http://dx.doi.org/10.1016/j.amjcard.2012.04.059] [PMID: 22633203]
[55]
Ishihara T, Iida O, Tosaka A, et al. Severity of coronary artery disease affects prognosis of patients with peripheral artery disease. Angiology 2013; 64(6): 417-22.
[http://dx.doi.org/10.1177/0003319712452627] [PMID: 22773383]
[56]
van Kuijk JP, Flu WJ, Welten GMJM, et al. Long-term prognosis of patients with peripheral arterial disease with or without polyvascular atherosclerotic disease. Eur Heart J 2010; 31(8): 992-9.
[http://dx.doi.org/10.1093/eurheartj/ehp553] [PMID: 20037181]
[57]
Gutierrez JA, Mulder H, Jones WS, et al. Polyvascular disease and risk of major adverse cardiovascular events in peripheral artery dis-ease. JAMA Netw Open 2018; 1(7): e185239.
[http://dx.doi.org/10.1001/jamanetworkopen.2018.5239] [PMID: 30646395]
[58]
Behan SA, Mulder H, Rockhold FW, et al. Impact of polyvascular disease and diabetes on limb and cardiovascular risk in peripheral ar-tery disease. J Am Coll Cardiol 2022; 79(17): 1781-3.
[http://dx.doi.org/10.1016/j.jacc.2022.02.031] [PMID: 35483761]
[59]
Razzouk L, Rockman CB, Patel MR, et al. Co-existence of vascular disease in different arterial beds: Peripheral artery disease and carotid artery stenosis – Data from Life Line Screening®. Atherosclerosis 2015; 241(2): 687-91.
[http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.029] [PMID: 26122189]
[60]
Safian RD, Textor SC. Renal-artery stenosis. N Engl J Med 2001; 344(6): 431-42.
[http://dx.doi.org/10.1056/NEJM200102083440607] [PMID: 11172181]
[61]
Dechering DG, Kruis HME, Adiyaman A, Thien T, Postma CT. Clinical significance of low-grade renal artery stenosis. J Intern Med 2010; 267(3): 305-15.
[http://dx.doi.org/10.1111/j.1365-2796.2009.02144.x] [PMID: 19754857]
[62]
Conlon PJ, Athirakul K, Kovalik E, et al. Survival in renal vascular disease. J Am Soc Nephrol 1998; 9(2): 252-6.
[http://dx.doi.org/10.1681/ASN.V92252] [PMID: 9527401]
[63]
Aboyans V, Desormais I, Magne J, Morange G, Mohty D, Lacroix P. Renal artery stenosis in patients with peripheral artery disease: Prevalence, risk factors and long-term prognosis. Eur J Vasc Endovasc Surg 2017; 53(3): 380-5.
[http://dx.doi.org/10.1016/j.ejvs.2016.10.029] [PMID: 27919610]
[64]
Manolis AS, Manolis AA, Melita H. Current status of renal artery angioplasty and stenting for resistant hypertension: A case series and review of the literature. Curr Hypertens Rev 2017; 13(2): 93-103.
[PMID: 28782466]
[65]
Burlacu A, Siriopol D, Voroneanu L, et al. Atherosclerotic renal artery stenosis prevalence and correlations in acute myocardial infarction patients undergoing primary percutaneous coronary interventions: Data from nonrandomized single‐center study (REN‐ACS)—a single center, prospective, observational study. J Am Heart Assoc 2015; 4(10): e002379.
[http://dx.doi.org/10.1161/JAHA.115.002379] [PMID: 26459932]
[66]
Amighi J, Schlager O, Haumer M, et al. Renal artery stenosis predicts adverse cardiovascular and renal outcome in patients with peripheral artery disease. Eur J Clin Invest 2009; 39(9): 784-92.
[http://dx.doi.org/10.1111/j.1365-2362.2009.02180.x] [PMID: 19522837]
[67]
Clair DG, Beach JM. Mesenteric ischemia. N Engl J Med 2016; 374(10): 959-68.
[http://dx.doi.org/10.1056/NEJMra1503884] [PMID: 26962730]
[68]
Dijk LJD, Noord D, Vries AC, et al. Clinical management of chronic mesenteric ischemia. United European Gastroenterol J 2019; 7(2): 179-88.
[http://dx.doi.org/10.1177/2050640618817698] [PMID: 31080602]
[69]
Roobottom CA, Dubbins PA. Significant disease of the celiac and superior mesenteric arteries in asymptomatic patients: Predictive value of Doppler sonography. AJR Am J Roentgenol 1993; 161(5): 985-8.
[http://dx.doi.org/10.2214/ajr.161.5.8273642] [PMID: 8273642]
[70]
Björck M, Koelemay M, Acosta S, et al. Editor’s choice – management of the diseases of mesenteric arteries and veins. Eur J Vasc Endovasc Surg 2017; 53(4): 460-510.
[http://dx.doi.org/10.1016/j.ejvs.2017.01.010] [PMID: 28359440]
[71]
Tallarita T, Oderich GS, Gloviczki P, et al. Patient survival after open and endovascular mesenteric revascularization for chronic mesenter-ic ischemia. J Vasc Surg 2013; 57(3): 747-55.
[http://dx.doi.org/10.1016/j.jvs.2012.09.047] [PMID: 23332245]
[72]
Valentine RJ, Martin JD, Myers SI, Rossi MB, Clagett GP. Asymptomatic celiac and superior mesenteric artery stenoses are more prevalent among patients with unsuspected renal artery stenoses. J Vasc Surg 1991; 14(2): 195-9.
[http://dx.doi.org/10.1067/mva.1991.29423] [PMID: 1861331]
[73]
Quaye KB, Pack N, Wilson-Byrne T, Long CA. Contemporary management of abdominal aortic aneurysms. Curr Cardiol Rep 2022; 24(4): 431-8.
[http://dx.doi.org/10.1007/s11886-022-01662-z] [PMID: 35107703]
[74]
Gray C, Goodman P, Cullen P, et al. Screening for peripheral arterial disease and carotid artery disease in patients with abdominal aortic aneurysm. Angiology 2016; 67(4): 346-9.
[http://dx.doi.org/10.1177/0003319715590299] [PMID: 26056393]
[75]
Marsico F, Giugliano G, Ruggiero D, et al. Prevalence and severity of asymptomatic coronary and carotid artery disease in patients with abdominal aortic aneurysm. Angiology 2015; 66(4): 360-4.
[http://dx.doi.org/10.1177/0003319714540319] [PMID: 24965380]
[76]
Lin YT, Chen HJ, Chen PC, Sung FC. Increased risk of peripheral arterial disease in patients with abdominal aortic aneurysm: A retrospec-tive cohort study (Version 5). Angiology 2019; 70(1): 41-6.
[http://dx.doi.org/10.1177/0003319718757615] [PMID: 29444589]
[77]
Hosokawa Y, Takano H, Aoki A, et al. Management of coronary artery disease in patients undergoing elective abdominal aortic aneurysm open repair. Clin Cardiol 2008; 31(12): 580-5.
[http://dx.doi.org/10.1002/clc.20335] [PMID: 19072880]
[78]
Hołda MK, Iwaszczuk P, Wszołek K, et al. Coexistence and management of abdominal aortic aneurysm and coronary artery disease. Cardiol J 2020; 27(4): 384-93.
[http://dx.doi.org/10.5603/CJ.a2018.0101] [PMID: 30234902]
[79]
Yamawaki M, Honda Y, Makino K, et al. Influence of polyvascular disease on clinical outcome in patients undergoing transcatheter aortic valve implantation via transfemoral access. PLoS One 2021; 16(12): e0260385.
[http://dx.doi.org/10.1371/journal.pone.0260385] [PMID: 34855791]
[80]
Tanaka S, Nakano T, Hiyamuta H, et al. Impact of multivascular disease on cardiovascular mortality and morbidity in patients receiving hemodialysis: Ten-year outcomes of the Q-cohort study. J Atheroscler Thromb 2021; 28(4): 385-95.
[http://dx.doi.org/10.5551/jat.54098] [PMID: 32684556]
[81]
Kablak-Ziembicka A, Przewlocki T, Pieniazek P, et al. The role of carotid intima-media thickness assessment in cardiovascular risk evalu-ation in patients with polyvascular atherosclerosis. Atherosclerosis 2010; 209(1): 125-30.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.019] [PMID: 19762025]
[82]
Poredos P, Jezovnik MK. Preclinical carotid atherosclerosis as an indicator of polyvascular disease: A narrative review. Ann Transl Med 2021; 9(14): 1204.
[http://dx.doi.org/10.21037/atm-20-5570] [PMID: 34430645]
[83]
Paskiewicz A, Wang FM, Yang C, et al. Ankle‐brachial index and subsequent risk of severe ischemic leg outcomes: The ARIC study. J Am Heart Assoc 2021; 10(22): e021801.
[http://dx.doi.org/10.1161/JAHA.121.021801] [PMID: 34726067]
[84]
van Kuijk JP, Flu WJ, Galal W, et al. The influence of polyvascular disease on the obesity paradox in vascular surgery patients. J Vasc Surg 2011; 53(2): 399-406.
[http://dx.doi.org/10.1016/j.jvs.2010.08.048] [PMID: 20965685]
[85]
Dong M, Jiang X, Liao JK, Yan BP. Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in poly-vascular disease patients with concomitant coronary and peripheral arterial disease. Clin Cardiol 2013; 36(6): 347-51.
[http://dx.doi.org/10.1002/clc.22118] [PMID: 23553913]
[86]
Mattina A, Giammanco A, Giral P, et al. Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender. Nutr Metab Cardiovasc Dis 2019; 29(10): 1068-76.
[http://dx.doi.org/10.1016/j.numecd.2019.06.015] [PMID: 31378630]
[87]
Sáez-Jiménez R, Esteban-Hernández J, Herreros B, Huelmos A, Guijarro C. Albuminuria and polyvascular disease improve multivariate predictive models after an acute cardiovascular event. The AIRVAG cohort. Rev Clin Esp 2022; 222(3): 138-51.
[http://dx.doi.org/10.1016/j.rceng.2021.01.003] [PMID: 34147423]
[88]
Manolis AA, Manolis TA, Melita H, Mikhailidis DP, Manolis AS. Low serum albumin: A neglected predictor in patients with cardiovascu-lar disease. Eur J Intern Med 2022; 102: 24-39.
[http://dx.doi.org/10.1016/j.ejim.2022.05.004] [PMID: 35537999]
[89]
Nakahashi T, Tada H, Sakata K, et al. Impact of concomitant peripheral artery disease on contrast-induced acute kidney injury and mortal-ity in patients with acute coronary syndrome after percutaneous coronary intervention. Heart Vessels 2020; 35(10): 1360-7.
[http://dx.doi.org/10.1007/s00380-020-01614-z] [PMID: 32342211]
[90]
Lüders F, Malyar N, Meyborg M, Gebauer K, Brand E, Reinecke H. Impact of peripheral arterial occlusive disease on the development of contrast medium-induced acute kidney injury. Nephron Clin Pract 2013; 122(1-2): 38-43.
[http://dx.doi.org/10.1159/000346105] [PMID: 23548372]
[91]
Aboyans V, Tanguy B, Desormais I, et al. Prevalence of renal artery disease and its prognostic significance in patients undergoing coro-nary bypass grafting. Am J Cardiol 2014; 114(7): 1029-34.
[http://dx.doi.org/10.1016/j.amjcard.2014.07.011] [PMID: 25150754]
[92]
Eagle KA, Rihal CS, Foster ED, Mickel MC, Gersh BJ. Long-term survival in patients with coronary artery disease: Importance of periph-eral vascular disease. J Am Coll Cardiol 1994; 23(5): 1091-5.
[http://dx.doi.org/10.1016/0735-1097(94)90596-7] [PMID: 8144774]
[93]
Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE. Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: Insights from the Heart and Soul Study. Vasc Med 2013; 18(4): 176-84.
[http://dx.doi.org/10.1177/1358863X13493825] [PMID: 23835937]
[94]
van Straten AHM, Firanescu C, Soliman Hamad MA, et al. Peripheral vascular disease as a predictor of survival after coronary artery by-pass grafting: Comparison with a matched general population. Ann Thorac Surg 2010; 89(2): 414-20.
[http://dx.doi.org/10.1016/j.athoracsur.2009.11.036] [PMID: 20103313]
[95]
Saw J, Bhatt DL, Moliterno DJ, et al. The influence of peripheral arterial disease on outcomes: A pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials. J Am Coll Cardiol 2006; 48(8): 1567-72.
[http://dx.doi.org/10.1016/j.jacc.2006.03.067] [PMID: 17045889]
[96]
Vrsalovic M, Vrsalovic Presecki A, Aboyans V. Cardiac troponins predict mortality and cardiovascular outcomes in patients with periph-eral artery disease: A systematic review and meta‐analysis of adjusted observational studies. Clin Cardiol 2022; 45(2): 198-204.
[http://dx.doi.org/10.1002/clc.23776] [PMID: 35132665]
[97]
Inglis SC, Bebchuk J, Al-Suhaim SA, et al. Peripheral artery disease and outcomes after myocardial infarction: An individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT. Int J Cardiol 2013; 168(2): 1094-101.
[http://dx.doi.org/10.1016/j.ijcard.2012.11.033] [PMID: 23194780]
[98]
Pickett CA, Jackson JL, Hemann BA, Atwood JE. Carotid bruits as a prognostic indicator of cardiovascular death and myocardial infarc-tion: A meta-analysis. Lancet 2008; 371(9624): 1587-94.
[http://dx.doi.org/10.1016/S0140-6736(08)60691-1] [PMID: 18468542]
[99]
Ahmed B, Al-Khaffaf H. Prevalence of significant asymptomatic carotid artery disease in patients with peripheral vascular disease: A me-ta-analysis. Eur J Vasc Endovasc Surg 2009; 37(3): 262-71.
[http://dx.doi.org/10.1016/j.ejvs.2008.10.017] [PMID: 19058982]
[100]
Alkhalil M, Kuzemczak M, Whitehead N, Kavvouras C, Džavík V. Meta‐analysis of intensive lipid‐lowering therapy in patients with polyvascular disease. J Am Heart Assoc 2021; 10(5): e017948.
[http://dx.doi.org/10.1161/JAHA.120.017948] [PMID: 33586467]
[101]
Carolei A, Chamorro A, Laloux P, et al. Identification and management of polyvascular disease in patients with noncardioembolic is-chaemic stroke. Int J Stroke 2008; 3(4): 237-48.
[http://dx.doi.org/10.1111/j.1747-4949.2008.00220.x] [PMID: 18811739]
[102]
Jönelid B, Johnston N, Berglund L, Andrén B, Kragsterman B, Christersson C. Ankle brachial index most important to identify polyvascu-lar disease in patients with non-ST elevation or ST-elevation myocardial infarction. Eur J Intern Med 2016; 30: 55-60.
[http://dx.doi.org/10.1016/j.ejim.2015.12.016] [PMID: 26776925]
[103]
Desjardins B, Dill KE, Flamm SD, et al. ACR Appropriateness Criteria® pulsatile abdominal mass, suspected abdominal aortic aneurysm. Int J Cardiovasc Imaging 2013; 29(1): 177-83.
[http://dx.doi.org/10.1007/s10554-012-0044-2] [PMID: 22644671]
[104]
Cecere A, Riccioni G, Sforza N, Marano R, Guglielmi G. Coronary artery calcium score and coronary computed tomography angiography for patients with asymptomatic polyvascular (non-coronary) atherosclerosis. Singapore Med J 2017; 58(9): 528-34.
[http://dx.doi.org/10.11622/smedj.2016186] [PMID: 27957585]
[105]
Sillesen H. Carotid intima-media thickness and/or carotid plaque: What is relevant? Eur J Vasc Endovasc Surg 2014; 48(2): 115-7.
[http://dx.doi.org/10.1016/j.ejvs.2014.04.026] [PMID: 24909979]
[106]
Paraskevas KI, Veith FJ, Mikhailidis DP. Carotid intima-media thickness and ezetimibe: The end of a misunderstanding? Curr Vasc Pharmacol 2011; 9(4): 381-4.
[http://dx.doi.org/10.2174/157016111796197198] [PMID: 21574949]
[107]
Paraskevas KI, Hamilton G, Mikhailidis DP. Clinical significance of carotid bruits: An innocent finding or a useful warning sign? Neurol Res 2008; 30(5): 523-30.
[http://dx.doi.org/10.1179/174313208X289525] [PMID: 18953744]
[108]
Paraskevas KI, Geroulakos G, Veith FJ, Mikhailidis DP. Multifocal arterial disease: Clinical implications and management. Curr Opin Cardiol 2020; 35(4): 412-6.
[http://dx.doi.org/10.1097/HCO.0000000000000746] [PMID: 32371620]
[109]
Jukema JW, Szarek M, Zijlstra LE, et al. Alirocumab in patients with polyvascular disease and recent acute coronary syndrome. J Am Coll Cardiol 2019; 74(9): 1167-76.
[http://dx.doi.org/10.1016/j.jacc.2019.03.013] [PMID: 30898609]
[110]
Oyama K, Giugliano RP, Tang M, et al. Effect of evolocumab on acute arterial events across all vascular territories: Results from the FOURIER trial. Eur Heart J 2021; 42(47): 4821-9.
[http://dx.doi.org/10.1093/eurheartj/ehab604] [PMID: 34537830]
[111]
Ikeda K, Takahashi T, Yamada H, et al. Effect of intensive statin therapy on regression of carotid intima-media thickness in patients with subclinical carotid atherosclerosis (a prospective, randomized trial: PEACE (Pitavastatin Evaluation of Atherosclerosis Regression by In-tensive Cholesterol-lowering Therapy) study). Eur J Prev Cardiol 2013; 20(6): 1069-79.
[http://dx.doi.org/10.1177/2047487312451539] [PMID: 22689416]
[112]
Nicholls SJ, Kataoka Y, Nissen SE, et al. Effect of evolocumab on coronary plaque phenotype and burden in statin-treated patients fol-lowing myocardial infarction. JACC Cardiovasc Imaging 2022; 15(7): 1308-21.
[http://dx.doi.org/10.1016/j.jcmg.2022.03.002] [PMID: 35431172]
[113]
Piccirillo F, Miano N, Goffredo C, et al. Impact of Mediterranean diet on metabolic and inflammatory status of patients with polyvascular atherosclerotic disease. Nutr Metab Cardiovasc Dis 2022; 32(1): 117-24.
[http://dx.doi.org/10.1016/j.numecd.2021.09.032] [PMID: 34802851]
[114]
Verma S, Mazer CD, Inzucchi SE, et al. Impact of polyvascular disease with and without co‐existent kidney dysfunction on cardiovascu-lar outcomes in diabetes: A post hoc analysis of EMPA‐REG OUTCOME. Diabetes Obes Metab 2021; 23(5): 1173-81.
[http://dx.doi.org/10.1111/dom.14326] [PMID: 33502090]
[115]
Poredos P, Blinc A, Novo S, Antignani PL. How to manage patients with polyvascular atherosclerotic disease. Position paper of the Inter-national Union of Angiology. Int Angiol 2021; 40(1): 29-41.
[http://dx.doi.org/10.23736/S0392-9590.20.04518-6] [PMID: 32892614]
[116]
Rizzo RJ, Whittemore AD, Couper GS, et al. Combined carotid and coronary revascularization: The preferred approach to the severe vas-culopath. Ann Thorac Surg 1992; 54(6): 1099-109.
[http://dx.doi.org/10.1016/0003-4975(92)90076-G] [PMID: 1449293]
[117]
Chang BB, Darling RC III, Shah DM, Paty PSK, Leather RP. Carotid endarterectomy can be safely performed with acceptable mortality and morbidity in patients requiring coronary artery bypass grafts. Am J Surg 1994; 168(2): 94-6.
[http://dx.doi.org/10.1016/S0002-9610(94)80043-X] [PMID: 8053534]
[118]
Akins CW, Moncure AC, Daggett WM, et al. Safety and efficacy of concomitant carotid and coronary artery operations. Ann Thorac Surg 1995; 60(2): 311-8.
[http://dx.doi.org/10.1016/0003-4975(95)00397-4] [PMID: 7646091]
[119]
Kihara S, Shimakura T, Tanaka SA, et al. Staged coronary artery bypass grafting after percutaneous angioplasty for intracranial vascular stenosis. J Thorac Cardiovasc Surg 2001; 122(3): 608-10.
[http://dx.doi.org/10.1067/mtc.2001.115159] [PMID: 11547317]
[120]
Antunes P, Anacleto G, de Oliveira JM, Eugénio L, Antunes MJ. Staged carotid and coronary surgery for concomitant carotid and coro-nary artery disease. Eur J Cardiothorac Surg 2002; 21(2): 181-6.
[http://dx.doi.org/10.1016/S1010-7940(01)01097-1] [PMID: 11825721]
[121]
Coyle KA, Gray BC, Smith RB III, et al. Morbidity and mortality associated with carotid endarterectomy: Effect of adjunctive coronary revascularization. Ann Vasc Surg 1995; 9(1): 21-7.
[http://dx.doi.org/10.1007/BF02015313] [PMID: 7703059]
[122]
Borger MA, Fremes SE, Weisel RD, et al. Coronary bypass and carotid endarterectomy: Does a combined approach increase risk? A metaanalysis. Ann Thorac Surg 1999; 68(1): 14-20.
[http://dx.doi.org/10.1016/S0003-4975(99)00474-9] [PMID: 10421108]
[123]
Barnes RW. Asymptomatic carotid disease in patients undergoing major cardiovascular operations: Can prophylactic endarterectomy be justified? Ann Thorac Surg 1986; 42(6): S36-40.
[http://dx.doi.org/10.1016/S0003-4975(10)64640-1] [PMID: 3539051]
[124]
Van der Heyden J, Lans HW, van Werkum JW, Schepens M, Ackerstaff RG, Suttorp MJ. Will carotid angioplasty become the preferred alternative to staged or synchronous carotid endarterectomy in patients undergoing cardiac surgery? Eur J Vasc Endovasc Surg 2008; 36(4): 379-84.
[http://dx.doi.org/10.1016/j.ejvs.2008.06.001] [PMID: 18620876]
[125]
Feldman DN, Swaminathan RV, Geleris JD, et al. Comparison of trends and in-hospital outcomes of concurrent carotid artery revasculari-zation and coronary artery bypass graft surgery. JACC Cardiovasc Interv 2017; 10(3): 286-98.
[http://dx.doi.org/10.1016/j.jcin.2016.11.032] [PMID: 28183469]
[126]
Sharma V, Deo SV, Park SJ, Joyce LD. Meta-analysis of staged versus combined carotid endarterectomy and coronary artery bypass graft-ing. Ann Thorac Surg 2014; 97(1): 102-9.
[http://dx.doi.org/10.1016/j.athoracsur.2013.07.091] [PMID: 24090581]
[127]
Illuminati G, Ricco JB, Greco C, et al. Systematic preoperative coronary angiography and stenting improves postoperative results of carot-id endarterectomy in patients with asymptomatic coronary artery disease: A randomised controlled trial. Eur J Vasc Endovasc Surg 2010; 39(2): 139-45.
[http://dx.doi.org/10.1016/j.ejvs.2009.11.015] [PMID: 20005750]
[128]
Chiappini B. Dell’ Amore A, Di Marco L, Di Bartolomeo R, Marinelli G. Simultaneous carotid and coronary arteries disease: Staged or combined surgical approach? J Card Surg 2005; 20(3): 234-40.
[http://dx.doi.org/10.1111/j.1540-8191.2005.200420.x] [PMID: 15854084]

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