Abstract
Carbohydrates are the most common biopolymers with the capability to construct supramolecular structures. For biomedical purposes, a variety of carbohydrate-based nanoparticles have been used. Basic monosaccharides or disaccharides, along with sophisticated polymeric systems, are used to create these structures. The shape and properties of these materials can be modified using chemical alterations. Carbohydrates-based nanogels and nanoparticles have been used for drug delivery, tissue engineering, and cell imaging. Carbohydrate-based elements are excellent derivatives for the production of responsive systems because of the reversible character of the assembly, which is frequently based on a mixture of hydrophobic interactions and hydrogen bonding. The present manuscript attempts to review the recent studies on carbohydrate-based nanomaterials and an update on the patents granted for the same.
Keywords: Carbohydrates, Nanoparticles, Polysaccharides, Pharmaceutical applications, Drug delivery.
Graphical Abstract
[http://dx.doi.org/10.1007/3-540-45010-6_2]
[http://dx.doi.org/10.1002/anie.201201114] [PMID: 22952048]
[http://dx.doi.org/10.1039/c3cs35483k] [PMID: 23400414]
[http://dx.doi.org/10.1021/acs.chemrev.5b00516] [PMID: 26702928]
[http://dx.doi.org/10.1021/cr100285v] [PMID: 21319765]
[http://dx.doi.org/10.1016/j.foodres.2016.11.016] [PMID: 28865611]
[http://dx.doi.org/10.1021/bm200260d] [PMID: 21524055]
[http://dx.doi.org/10.1039/C6OB01124A]
[http://dx.doi.org/10.1002/wnan.1558] [PMID: 31063240]
[http://dx.doi.org/10.1021/bm3010325] [PMID: 23017146]
[http://dx.doi.org/10.1021/cr500081p] [PMID: 25247843]
[http://dx.doi.org/10.1002/anie.200460587] [PMID: 15861454]
[http://dx.doi.org/10.1039/c0cs00108b] [PMID: 21566801]
[http://dx.doi.org/10.1007/s10570-018-1723-5]
[http://dx.doi.org/10.1002/masy.201800115]
[http://dx.doi.org/10.1016/j.matlet.2017.07.090]
[http://dx.doi.org/10.1002/masy.200850210]
[http://dx.doi.org/10.1021/jf3001873] [PMID: 22439596]
[http://dx.doi.org/10.1016/j.polymer.2015.01.024]
[http://dx.doi.org/10.1016/j.ijbiomac.2014.12.052] [PMID: 25680962]
[http://dx.doi.org/10.1002/jctb.1322]
[http://dx.doi.org/10.1021/acs.chemrev.6b00532] [PMID: 28032507]
[http://dx.doi.org/10.1016/j.carbpol.2008.01.003] [PMID: 26048217]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.03.106] [PMID: 29581001]
[http://dx.doi.org/10.1016/j.biomaterials.2016.10.045] [PMID: 27815997]
[http://dx.doi.org/10.1016/j.biopha.2018.07.136] [PMID: 30086465]
[http://dx.doi.org/10.2174/221279680801141112095704]
[http://dx.doi.org/10.1039/C6GC02827F]
[http://dx.doi.org/10.1016/j.progpolymsci.2006.06.001]
[http://dx.doi.org/10.1016/j.addr.2015.11.002] [PMID: 26555370]
[http://dx.doi.org/10.1002/pat.4375]
[http://dx.doi.org/10.3390/md14030042] [PMID: 26927134]
[http://dx.doi.org/10.1002/macp.200900562]
[http://dx.doi.org/10.1016/j.carres.2009.05.021] [PMID: 19616198]
[http://dx.doi.org/10.1080/10942912.2013.809541]
[http://dx.doi.org/10.1016/j.ijpharm.2014.03.038] [PMID: 24657577]
[http://dx.doi.org/10.1039/C5RA09183G]
[http://dx.doi.org/10.1021/cr940413g] [PMID: 11848911]
[http://dx.doi.org/10.1021/bm0700901] [PMID: 17397218]
[http://dx.doi.org/10.1016/S0040-4020(03)00438-1]
[http://dx.doi.org/10.1039/c2cc16656a] [PMID: 22212450]
[http://dx.doi.org/10.1002/asia.201700202] [PMID: 28317269]
[http://dx.doi.org/10.1038/nnano.2017.109] [PMID: 28650443]
[http://dx.doi.org/10.3390/gels7010024] [PMID: 33652820]
[http://dx.doi.org/10.1021/acs.biomac.5b01669] [PMID: 26716910]
[http://dx.doi.org/10.1002/anie.201409134] [PMID: 25693962]
[http://dx.doi.org/10.1021/ja5111893] [PMID: 25539667]
[http://dx.doi.org/10.1016/j.actbio.2018.04.019] [PMID: 29660509]
[http://dx.doi.org/10.1021/acs.chemrev.8b00066] [PMID: 30011195]
[http://dx.doi.org/10.1023/A:1012136608249] [PMID: 9165524]
[http://dx.doi.org/10.1016/j.molstruc.2014.03.051]
[http://dx.doi.org/10.1016/j.ijpharm.2017.04.049] [PMID: 28450165]
[http://dx.doi.org/10.1016/j.ijpharm.2017.06.010] [PMID: 28596142]
[http://dx.doi.org/10.1016/j.jconrel.2004.02.010] [PMID: 15120897]
[http://dx.doi.org/10.1016/j.ijpharm.2015.09.052] [PMID: 26410753]
[http://dx.doi.org/10.1016/j.ijpharm.2015.07.040] [PMID: 26220650]
[http://dx.doi.org/10.1016/j.colsurfb.2011.11.043] [PMID: 22186134]
[http://dx.doi.org/10.3762/bjnano.8.145] [PMID: 28900599]
[http://dx.doi.org/10.18433/J3K308] [PMID: 22365092]
[http://dx.doi.org/10.1016/j.ijpharm.2012.12.031] [PMID: 23279938]
[http://dx.doi.org/10.1007/s10847-014-0406-6]
[http://dx.doi.org/10.1002/cplu.201500531]
[http://dx.doi.org/10.1007/s10637-017-0538-9] [PMID: 29116478]
[http://dx.doi.org/10.1039/c2cs35424a] [PMID: 23340678]
[http://dx.doi.org/10.1016/j.carbpol.2015.05.087] [PMID: 26256342]
[http://dx.doi.org/10.1002/chem.201603294] [PMID: 27714939]
[http://dx.doi.org/10.1002/macp.201600160]
[http://dx.doi.org/10.3762/bjnano.9.189] [PMID: 30116690]
[http://dx.doi.org/10.1016/j.dental.2017.08.033]
[http://dx.doi.org/10.1088/1748-6041/6/6/065005] [PMID: 22089383]
[http://dx.doi.org/10.1039/C8TB02291G] [PMID: 32254691]
[http://dx.doi.org/10.1016/j.ijpharm.2015.08.047] [PMID: 26302862]
[http://dx.doi.org/10.1021/ma102801f]
[http://dx.doi.org/10.1016/j.foodhyd.2016.07.020]
[http://dx.doi.org/10.2147/IJN.S138624] [PMID: 28814860]
[http://dx.doi.org/10.1039/C6RA00260A]
[http://dx.doi.org/10.1016/j.carbpol.2018.04.105] [PMID: 29804993]
[http://dx.doi.org/10.1016/j.biomaterials.2015.04.032] [PMID: 25956852]
[http://dx.doi.org/10.4155/tde.15.91] [PMID: 26769109]
[http://dx.doi.org/10.1039/C5TB00900F] [PMID: 32262797]
[http://dx.doi.org/10.1016/j.reactfunctpolym.2016.03.013]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.03.103] [PMID: 28344094]
[http://dx.doi.org/10.3109/02652048.2010.529947] [PMID: 21171817]
[http://dx.doi.org/10.7150/thno.21052] [PMID: 29290789]
[http://dx.doi.org/10.1016/j.msec.2018.08.015] [PMID: 30274122]
[http://dx.doi.org/10.1002/adhm.201600642] [PMID: 27594343]
[http://dx.doi.org/10.1002/adma.201000307] [PMID: 20518040]
[http://dx.doi.org/10.1016/j.jconrel.2017.11.023] [PMID: 29146242]
[http://dx.doi.org/10.1021/mp900311x] [PMID: 20230025]
[http://dx.doi.org/10.2147/IJN.S171925] [PMID: 30038493]
[http://dx.doi.org/10.1021/mp2003785] [PMID: 22149217]
[http://dx.doi.org/10.1039/C4NR03514C] [PMID: 25171376]
[http://dx.doi.org/10.1039/C5TB01496D] [PMID: 32262878]
[http://dx.doi.org/10.1007/s10853-017-1249-5]
[http://dx.doi.org/10.1016/j.msec.2017.04.013] [PMID: 28532106]
[http://dx.doi.org/10.1016/j.biomaterials.2017.03.044] [PMID: 28371624]
[http://dx.doi.org/10.1002/masy.200390130]
[http://dx.doi.org/10.1002/adfm.201705134]
[http://dx.doi.org/10.1016/j.jcis.2018.02.076] [PMID: 29621645]
[http://dx.doi.org/10.1021/bm301286h] [PMID: 23215439]
[http://dx.doi.org/10.1016/j.ejpb.2017.06.011] [PMID: 28610879]
[http://dx.doi.org/10.1021/acs.biomac.8b01210] [PMID: 30347145]
[http://dx.doi.org/10.1016/j.eurpolymj.2018.10.042]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.08.071] [PMID: 28818724]
[http://dx.doi.org/10.1016/j.msec.2012.12.032] [PMID: 23827578]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.12.008] [PMID: 29217184]
[http://dx.doi.org/10.1039/C6TB00021E] [PMID: 27453781]
[http://dx.doi.org/10.1016/j.carbpol.2018.06.114] [PMID: 30143150]
[http://dx.doi.org/10.1016/j.carres.2004.09.007] [PMID: 15519328]
[http://dx.doi.org/10.1021/ar200234q] [PMID: 22236133]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.09.032] [PMID: 30201564]
[http://dx.doi.org/10.1016/j.carbpol.2018.09.011] [PMID: 30287013]
[http://dx.doi.org/10.1016/j.biomaterials.2013.10.005] [PMID: 24140042]
[http://dx.doi.org/10.1021/acsami.5b02324] [PMID: 25905780]
[http://dx.doi.org/10.1016/j.nano.2011.11.002] [PMID: 22100756]
[http://dx.doi.org/10.1016/j.jconrel.2016.01.049] [PMID: 26826304]
[http://dx.doi.org/10.1016/j.carbpol.2016.01.026] [PMID: 27083829]
[http://dx.doi.org/10.1021/acs.molpharmaceut.8b00620] [PMID: 30248267]
[http://dx.doi.org/10.1016/j.carbpol.2016.07.030] [PMID: 27516333]
[http://dx.doi.org/10.1016/j.carbpol.2016.06.085] [PMID: 27474668]
[http://dx.doi.org/10.1089/pho.2007.2089] [PMID: 17975957]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.03.004] [PMID: 29505869]
[http://dx.doi.org/10.1016/j.carbpol.2017.07.003] [PMID: 28821122]
[http://dx.doi.org/10.1016/j.colsurfb.2018.08.003] [PMID: 30114654]
[http://dx.doi.org/10.1248/cpb.c17-00824] [PMID: 29269686]
[http://dx.doi.org/10.1002/mabi.201600221] [PMID: 27456215]
[http://dx.doi.org/10.1016/j.jconrel.2016.08.027] [PMID: 27568289]
[http://dx.doi.org/10.1016/j.actbio.2018.09.022] [PMID: 30240956]
[http://dx.doi.org/10.1016/j.jcis.2017.02.033] [PMID: 28237749]
[http://dx.doi.org/10.1021/acsami.5b12347] [PMID: 27058058]
[http://dx.doi.org/10.1016/j.ijbiomac.2017.11.126] [PMID: 29169943]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.08.177] [PMID: 30171959]
[http://dx.doi.org/10.1039/C6RA23386D]
[http://dx.doi.org/10.1002/pen.23415]
[http://dx.doi.org/10.1016/j.msec.2006.10.008]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.06.050] [PMID: 29906535]
[http://dx.doi.org/10.1016/j.actbio.2013.06.036] [PMID: 23816652]
[http://dx.doi.org/10.1039/C7NJ03973E]
[http://dx.doi.org/10.1002/adv.21808]
[http://dx.doi.org/10.1021/acsami.7b04428] [PMID: 28640580]
[http://dx.doi.org/10.1021/acs.molpharmaceut.7b00926] [PMID: 29366318]
[http://dx.doi.org/10.3390/polym10040418] [PMID: 30966453]
[http://dx.doi.org/10.1016/j.tifs.2016.04.008]
[http://dx.doi.org/10.1007/s40204-020-00128-1] [PMID: 32072566]
[http://dx.doi.org/10.1016/j.colsurfb.2008.05.007] [PMID: 18583109]
[http://dx.doi.org/10.1016/j.colsurfb.2019.02.031] [PMID: 30785037]
[http://dx.doi.org/10.1002/pi.5970]
[http://dx.doi.org/10.1016/j.carbpol.2017.07.058] [PMID: 28917853]
[http://dx.doi.org/10.1021/acsami.6b03245] [PMID: 27378419]
[http://dx.doi.org/10.3389/fbioe.2019.00074] [PMID: 31024906]
[http://dx.doi.org/10.1038/nm.3337] [PMID: 24056773]
[http://dx.doi.org/10.1002/masy.200550932]