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Mini-Review Article

Fabrication and Applications of Raft-Forming System - An Emerging Trend in Gastro-retentive Drug Delivery System

Author(s): Dipthi Shree*, Chinam Niranjan Patra and Biswa Mohan Sahoo

Volume 12, Issue 3, 2022

Published on: 26 August, 2022

Article ID: e070722206711 Pages: 9

DOI: 10.2174/2210681212666220707141136

Price: $65

Abstract

Background and Objective: In the past several decades, the gastro-retentive drug delivery system is considered a novel approach which has gained immense popularity in the field of novel drug delivery systems. Among several approaches to achieving gastric retention raft-forming system which comes under the classification of floating drug delivery system is a subject of special research interest. This advanced drug delivery system has the potential to attain a prolonged and predictable drug delivery at specific sites of the GI tract mainly in the stomach and intestine thereby exhibiting a relatively constant plasma profile. Thus, the floating raft-forming system finds usefulness over conventional therapeutics to treat several gastrointestinal disorders viz., gastroesophageal reflux disorder, acid reflux, peptic ulcer, esophagitis, etc.

Methods: In this current manuscript, an extensive search is performed for original research papers using databases viz., Google Scholar, PubMed, Science Direct, etc. Further, painstaking efforts are made to compile and update the recent findings of the formulation scientists working exclusively in the area of raft-forming systems. This article portrays a detailed survey about several applications of raft-forming systems in the form of tables.

Conclusion: The floating raft-forming system has the potential for controlled drug release in the upper part of the GI tract and exerts improved bioavailability of the medications having a narrow absorption window. Thus, it is concluded that this advanced dosage form is the caliber candidate for the treatment of several gastrointestinal ailments.

Keywords: Novel drug delivery, gastroesophageal reflux disorder, buoyancy, gastric retention, floating system, migrating myoelectric cycle, gastric residence time, gastric emptying time, therapeutic efficacy

Graphical Abstract

[1]
Sahoo, D.P.; Bhandaru, R.; Samal, S.K.; Naik, R.; Kumar, P.; Kesharwani, P.; Dandela, R. Oral drug delivery of nanomedicine. In: Theory and Applications of Nonparenteral Nanomedicines; Academic Press; Elsevier, 2021; pp. 181-207.
[http://dx.doi.org/10.1016/B978-0-12-820466-5.00009-0]
[2]
Homayun, B.; Lin, X.; Choi, H.J. Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics, 2019, 11(3), 129.
[http://dx.doi.org/10.3390/pharmaceutics11030129] [PMID: 30893852]
[3]
Wen, H.; Jung, H.; Li, X. Drug delivery approaches in addressing clinical pharmacology-related issues: Opportunities and challenges. AAPS J., 2015, 17(6), 1327-1340.
[http://dx.doi.org/10.1208/s12248-015-9814-9] [PMID: 26276218]
[4]
Hua, S. Drug delivery from polymer-based nanopharmaceuticals-an experimental study complemented by simulations of selected diffusion processes. Front. Pharmacol., 2020, 11, 524.
[http://dx.doi.org/10.3389/fphar.2020.00524] [PMID: 32425781]
[5]
Shargel, L.; Wu-Pong, S.; Yu, A. Modified-release drug products. Applied Biopharmaceutics & Pharmacokinetics, 4th ed.; McGraw Hill, 1999, pp. 169-71.
[6]
Vyas, S.P.; Khar, R.K. Controlled Drug Delivery System-Concepts and Advances, 1st ed; Vallabh Prakashan, 2002, pp. 3-53.
[7]
Lachman, L.; Liebermann, H.A. The Theory and Practice of Industrial Pharmacy, 4th ed.; CBS Publishers & Distributors, Pvt. Ltd., 2013, pp. 597-628.
[8]
Gupta, R.; Tripathi, P.; Bhardwaj, P.; Mahor, A. Recent advances in gastro retentive drug delivery systems and its application on treatment of H. Pylori infections. J. Anal. Pharm. Res., 2018, 7(4), 404-410.
[http://dx.doi.org/10.15406/japlr.2018.07.00258]
[9]
Sharma, A.R.; Khan, A. Gastroretentive drug delivery system: An approach to enhance gastric retention for prolonged drug release. Int. J. Pharm. Sci. Res., 2013, 5(4), 1095-1106.
[10]
Bharadwaj, L.; Sharma, P.K.; Malviya, R. A Short review on gastro retentive formulations for stomach specific drug delivery: Special emphasis on floating in situ gel systems. Afr. J. Basic Appl. Sci., 2011, 3(6), 300-312.
[11]
Vinod, K.R.; Vasa, S.; Anbuazaghan, S.; Banji, D.; Padmasri, A.; Sandhya, S. Approaches for gastrotentive drug delivery systems. Int. J. Appl. Biol. Pharm., 2010, 1(2), 589-601.
[12]
More, S.; Gavali, K.; Doke, O.; Kasgawade, P. Gastroretentive drug delivery system. J. Drug Deliv. Ther., 2018, 8(4), 24-35.
[http://dx.doi.org/10.22270/jddt.v8i4.1788]
[13]
Patel, R.; Vaishnav, G. Raft forming system-gastroretentive drug delivery system. Int. J.Manag. Sci. Eng. Manag., 2020, 6(12), 515-519.
[14]
Greenwood-Van Meerveld, B.; Johnson, A.C.; Grundy, D. Gastrointestinal physiology and functions. Handb. Exp. Pharmacol., 2017, 239, 1-16.
[http://dx.doi.org/10.1007/164_2016_118] [PMID: 28176047]
[15]
Aulton’s pharmaceutics: The Design and Manufacture of Medicines, 5th ed; Churchill livingstone, Elsevier, 2017, pp. 270-285.
[16]
Kitazawa, T.; Kaiya, H. Regulation of gastrointestinal motility by motilin and ghrelin in vertebrate. Front. Endocrinol., 2017, 10, 278.
[http://dx.doi.org/10.3389/fendo.2019.00278]
[17]
Feher, J. Quantitative Human Physiology: An Introduction, 1st ed; Academic Press, 2012, pp. 701-710.
[http://dx.doi.org/10.1016/B978-0-12-382163-8.00078-5]
[18]
Bhavsar, D.N.; Varde, N.M.; Surendran, C.S.; Shah, V.H.; Upadhyay, U.M. Advance in GRDDS: Raft forming system a review. J. Drug Deliv. Ther., 2012, 2(5), 123-128.
[http://dx.doi.org/10.22270/jddt.v2i5.228]
[19]
Pawar, A.Y.; Jadhav, K.R.; Nikam, N.M. A Raft Forming System: An novel approach for gastroretention. Int. J. Pure App. Biosci., 2015, 3(4), 178-192.
[20]
Panda, S.; Madhusrota, P.; Sethi, G. Raft forming drug delivery system: A review. J. Pharm. Sci. & Res., 2019, 11(12), 3761-3772.
[21]
Pandav, S.S. Raft forming gastro retentive drug delivery system: A novel approach. Int. J. Creat. Res., 2020, 8(7), 4173-4184.
[22]
Raut, S.S.; Shinde, H.A. In-situ raft forming system: A review. Int. J. Pharmacogn, 2018, 5(6), 337-349.
[23]
Prajapati, V.D.; Jani, G.K.; Khutliwala, T.A.; Zala, B.S. Raft forming system-an upcoming approach of gastroretentive drug delivery system. J. Control. Release, 2013, 168(2), 151-165.
[http://dx.doi.org/10.1016/j.jconrel.2013.02.028] [PMID: 23500062]
[24]
Dolas, R.T.; Hosmani, A.; Somwanshi, S.B. Raft technology for gastro retentive drug delivery. Int. J. Pharm. Pharm. Res., 2015, 3(1), 232-252.
[25]
Ibrahim, M.; Naguib, Y.W.; Sarhan, H.A.; Abdelkader, H. Gastro-retentive oral drug delivery systems: A promising approach for narrow absorption window drugs. J. Adv. Biomed. & Pharm. Sci., 2019, 2(0), 98-111.
[http://dx.doi.org/10.21608/jabps.2019.11357.1042]
[26]
Sharma, D.; Sharma, A. Gastroretentive drug delivery system-a mini review. Asian Pac. J. Health Sci., 2014, 1(2), 80-89.
[http://dx.doi.org/10.21276/apjhs.2014.1.2.9]
[27]
Nayak, A.K.; Maji, R.; Das, B. Gastroretentive drug delivery system: A review. Asian J. Pharm. Clin. Res., 2010, 3(1), 2-10.
[28]
Shah, S.H.; Patel, J.K.; Patel, N.V. Stomach specific floating drug delivery system: A review. Int. J. Pharm. Tech. Res., 2009, 1(3), 623-633.
[29]
Kanabar, V.B.; Patel, V.P.; Doshi, S.M. Raft forming tablets: A novel drug delivery system. Eur. J. Pharm. Med. Res., 2015, 2(4), 185-203.
[30]
Porwal, A.; Dwivedi, H.; Pathak, K. Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy. Braz. J. Pharm. Sci., 2017, 53(3), e00173.
[http://dx.doi.org/10.1590/s2175-97902017000300173]
[31]
Bhalla, N.; Goswami, M. Floating drug delivery system. Int. J. Pharm. Res. Allied Sci, 2012, 1(4), 20-28.
[32]
Mandel, K.G.; Daggy, B.P.; Brodie, D.A.; Jacoby, H.I. Review article: Alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment. Pharmacol. Ther., 2000, 14(6), 669-690.
[http://dx.doi.org/10.1046/j.1365-2036.2000.00759.x] [PMID: 10848650]
[33]
Salvatore, S.; Ripepi, A.; Huysentruyt, K.; van de Maele, K.; Nosetti, L.; Agosti, M.; Salvatoni, A.; Vandenplas, Y. The effect of alginate in gastroesophageal reflux in infants. Paediatr. Drugs, 2018, 20(6), 575-583.
[http://dx.doi.org/10.1007/s40272-018-0314-0] [PMID: 30182358]
[34]
Dettmar, P.W.; Gil-Gonzalez, D.; Fisher, J.; Flint, L.; Rainforth, D.; Moreno-Herrera, A.; Potts, M. A comparative study on the raft chemical properties of various alginate antacid raftforming products. Drug Dev. Ind. Pharm., 2018, 44(1), 30-39.
[http://dx.doi.org/10.1080/03639045.2017.1371737] [PMID: 28836872]
[35]
Tytgat, G.N.; Simoneau, G. Clinical and laboratory studies of the antacid and raftforming properties of Rennie alginate suspension. Aliment. Pharmacol. Ther., 2006, 23(6), 759-765.
[http://dx.doi.org/10.1111/j.1365-2036.2006.02814.x] [PMID: 16556178]
[36]
Thomford, N.E.; Senthebane, D.A.; Rowe, A.; Munro, D.; Seele, P.; Maroyi, A.; Dzobo, K. Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int. J. Mol. Sci., 2018, 19(6), 1578.
[http://dx.doi.org/10.3390/ijms19061578] [PMID: 29799486]
[37]
Yuan, H.; Ma, Q.; Ye, L.; Piao, G. The Traditional medicine and modern medicine from natural products. Molecules, 2016, 21(5), 559.
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[38]
Obeid, M.A.; Al Qaraghuli, M.M.; Alsaadi, M.; Alzahrani, A.R.; Niwasabutra, K.; Ferro, V.A. Delivering natural products and biotherapeutics to improve drug efficacy. Ther. Deliv., 2017, 8(11), 947-956.
[http://dx.doi.org/10.4155/tde-2017-0060] [PMID: 29061102]
[39]
Hatton, F.L. Recent advances in RAFT polymerization of monomers derived from renewable resources. Polym. Chem., 2019, 11(2), 220-229.
[http://dx.doi.org/10.1039/C9PY01128E]
[40]
Awasthi, R.; Kulkarni, G.T. Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: Where do we stand? Drug Deliv., 2016, 23(2), 378-394.
[http://dx.doi.org/10.3109/10717544.2014.936535] [PMID: 25026414]
[41]
Kamsali, A.; Eranti, B.; Mounika, C.H.; Manne, R.; Barghav, C.; Reddy, S. Development and optimization of Amoxicillin floating raft system to effectively treat Helicobacter pylori infection. Ars Pharm., 2020, 61(3), 163-168.
[42]
Teaima, M.H.; Abdel Hamid, M.M.; Shoman, N.A.; Jasti, B.R.; El-Nabarawi, M.A.; Yasser, M. Formulation, characterization and comparative pharmacokinetic study of bupropion floating raft system as a promising approach for treating depression. J. Pharm. Sci., 2020, 109(11), 3451-3461.
[http://dx.doi.org/10.1016/j.xphs.2020.08.011] [PMID: 32835701]
[43]
Yerikala, R.; Pudi, V.P.; Saravanakumar, K.; Vadhireddy, S. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach. J. Drug Deliv. Ther., 2017, 7(4), 110-119.
[http://dx.doi.org/10.22270/jddt.v7i4.1473]
[44]
Prajapati, S.T.; Mehta, A.P.; Modhia, I.P.; Patel, C.N. Formulation and optimisation of raftforming chewable tablets containing H2 antagonist. Int. J. Pharm. Investig., 2012, 2(4), 176-182.
[http://dx.doi.org/10.4103/2230-973X.106988] [PMID: 23580933]
[45]
Reddy, Y.S.C.K.; Rao, G.S.N.K.; Annapurna, A.; Murthy, K.V.R. Preparation and evaluation of raft forming systems of Furosemide. World J. Pharm. Sci, 2021, 9(4), 34-39.
[46]
Abouelatta, S.M.; Aboelwafa, A.A.; El-Gazayerly, O.N. Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug. Drug Deliv., 2018, 25(1), 1161-1174.
[http://dx.doi.org/10.1080/10717544.2018.1474969] [PMID: 29792353]
[47]
Hanif, M.; Shah, S.; Rasul, A.; Abbas, G.; Zaman, M.; Amjad, M.W.; Abdul Ghafoor Raja, M.; Khan, H.U.; Ashfaq, M.; Iqbal, O. Enhancement of oral bioavailability of Ibandronate through gastroretentive raft forming drug delivery system: in vitro and in vivo evaluation. Int. J. Nanomed., 2020, 15, 4847-4858.
[http://dx.doi.org/10.2147/IJN.S255278] [PMID: 32764922]
[48]
Patel, D.M.; Patel, D.G.; Patel, C.N. Formulation and optimization of raft forming chewable tablet containing Lafutidine. Int. J. Pharm. Sci. Drug Res., 2015, 7(3), 229-234.
[49]
Deokar, G.S.; Raut, S.S.; Kshirsagar, S.J. An attempt to understand and validate the factors controlling in-situ raft formation process. Int. J. Pharm. Sci. Res., 2019, 10(10), 4657-4667.
[50]
Sarkar, R.K.; Gnana, P.K.; Kumar, B.; Prasad, K.; Madhavi, C.; Gobinath, M. Formulation and evaluation of gastro-retentive drug delivery system of losartan potassium by using raftforming approach. Int. J. Res. Pharm. Sci., 2015, 6(2), 204-212.
[51]
El Nabarawi, M.A.; Teaima, M.H.; Abd El-Monem, R.A.; El Nabarawy, N.A.; Gaber, D.A. Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. Drug Des. Devel. Ther., 2017, 11, 1081-1093.
[http://dx.doi.org/10.2147/DDDT.S131936] [PMID: 28435220]
[52]
Hanif, M.; Abbas, G.; Shah, S.; Zaman, M.; Rasul, A.; Majeed, A.; Khan, S.M.; Ahmed, M.M. raftforming system for Pantoprazole and Domperidone delivery: In vitro. and in vivo study. Bioinspired. Biomim. Nanobiomater., 2020, 9(3), 137-146.
[http://dx.doi.org/10.1680/jbibn.19.00031]
[53]
Bineesha, K.B.; Dharan, S.S.; Panicker, J.T.; James, J.E.; Jousha, S.A. Formulation and in vitro evaluation of gastroretentive raft drug delivery of Propranolol. Br. J. Bio. Med. Res., 2019, 3(4), 929-946.
[54]
Shah, S.; Hanif, M.; Abbas, G.; Rasul, A.; Zaman, M.; Rehman, A.; Khan, H.U.; Maheen, S.; Ashfaq, M.; Iqbal, O. Prompt drug delivery of Rabeprazole through raft formation: In vitro and in vivo evaluation. J. Drug Deliv. Sci. Technol., 2020, 60, 101932.
[http://dx.doi.org/10.1016/j.jddst.2020.101932]
[55]
Soni, H.; Patel, V.A. Formulation and in vitro evaluation of raft forming chewable tablets of Ranitidine Hydrochloride. Int. J. Sci. Res., 2016, 5(4), 181-186.
[56]
Omar, M.M.; Eleraky, N.E. Formulation and evaluation of the prepared floating raft system of Tizanidine HCl. Indian. J. Res Pharm. Biotech., 2017, 5(6), 392-408.
[57]
Wannasarit, S.; Mahattanadul, S.; Issarachot, O.; Puttarak, P.; Wiwattanapatapee, R. raftforming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. Eur. J. Pharm. Sci., 2020, 143, 105204.
[http://dx.doi.org/10.1016/j.ejps.2019.105204] [PMID: 31870812]
[58]
Kerdsakundee, N.; Mahattanadul, S.; Wiwattanapatapee, R. Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment. Eur. J. Pharm. Biopharm., 2015, 94, 513-520.
[http://dx.doi.org/10.1016/j.ejpb.2015.06.024] [PMID: 26143367]
[59]
Bhatt, P.P.; Patel, D.J. Formulation and evaluation of raft forming gallic acid chewable tablets for peptic ulcer. Int. J. Pharm. Sci. Rev. Res., 2018, 50(1), 68-76.
[60]
Bunlung, S.; Nualnoi, T.; Issarachot, O.; Wiwattanapatapee, R. Development of raftforming liquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharm. J., 2021, 29(10), 1143-1154.
[http://dx.doi.org/10.1016/j.jsps.2021.08.005] [PMID: 34703368]
[61]
Strugala, V.; Dettmar, P.W.; Thomas, E.C. Evaluation of an innovative over-the-counter treatment for symptoms of reflux disease: Quick-dissolving alginate granules. ISRN Pharm., 2012, 2012, 950162.
[http://dx.doi.org/10.5402/2012/950162] [PMID: 23320198]
[62]
Lee, K.Y.; Mooney, D.J. Alginate: Properties and biomedical applications. Prog. Polym. Sci., 2012, 37(1), 106-126.
[http://dx.doi.org/10.1016/j.progpolymsci.2011.06.003] [PMID: 22125349]
[63]
Hampson, F.C.; Farndale, A.; Strugala, V.; Sykes, J.; Jolliffe, I.G.; Dettmar, P.W. Alginate rafts and their characterisation. Int. J. Pharm., 2005, 294(1-2), 137-147.
[http://dx.doi.org/10.1016/j.ijpharm.2005.01.036] [PMID: 15814238]
[64]
Chevrel, B. A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium--aluminium antacid gel. J. Int. Med. Res., 1980, 8(4), 300-302.
[http://dx.doi.org/10.1177/030006058000800411] [PMID: 6250928]
[65]
Freitas, C.M.P.; Coimbra, J.S.R.; Souza, V.G.L.; Souza, R.C.S. Structure and applications of pectin in food, biomedical, and pharmaceutical industry: A review. Coatings, 2021, 11(8), 922.
[http://dx.doi.org/10.3390/coatings11080922]
[66]
Havelund, T.; Aalykke, C. The efficacy of a pectin-based raftforming anti-reflux agent in endoscopy-negative reflux disease. Scand. J. Gastroenterol., 1997, 32(8), 773-777.
[http://dx.doi.org/10.3109/00365529708996533] [PMID: 9282968]
[67]
Sharma, V.K.; Mazumder, B.; Nautiyal, V. Rheological characterization of isapgol husk, gum katira hydrocolloids, and their blends. Int. J. Food Sci., 2014, 2014, 506591.
[http://dx.doi.org/10.1155/2014/506591] [PMID: 26904636]
[68]
Mandlekar, S.V.; Marathe, S.S.; Devarajan, P.V. A novel raftforming antacid suspension using natural dietary fiber. Int. J. Pharm., 1997, 148(1), 117-121.
[http://dx.doi.org/10.1016/S0378-5173(96)04835-1]
[69]
Kumar, A.; Rao, K.M.; Han, S.S. Application of xanthan gum as polysaccharide in tissue engineering: A review. Carbohydr. Polym., 2018, 180, 128-144.
[http://dx.doi.org/10.1016/j.carbpol.2017.10.009] [PMID: 29103488]
[70]
Yousaf, M.; Nirwan, J.S.; Smith, A.M.; Timmins, P.; Conway, B.R.; Ghori, M.U. raftforming polysaccharides for the treatment of Gastroesophageal Reflux Disease (GORD): Systematic review. J. Appl. Polym. Sci., 2019, 136(40), 48012.
[http://dx.doi.org/10.1002/app.48012]
[71]
Adepu, S.; Ramakrishna, S. Controlled drug Delivery Systems: Current status and future directions. Molecules, 2021, 26(19), 5905.
[http://dx.doi.org/10.3390/molecules26195905] [PMID: 34641447]
[72]
Kapadia, C.J.; Mane, V.B. raftforming agents: Antireflux formulations. Drug Dev. Ind. Pharm., 2007, 33(12), 1350-1361.
[http://dx.doi.org/10.1080/03639040701385691] [PMID: 18097809]
[73]
Kwiatek, M.A.; Roman, S.; Fareeduddin, A.; Pandolfino, J.E.; Kahrilas, P.J. An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial ‘acid pocket’ in symptomatic GERD patients. Aliment. Pharmacol. Ther., 2011, 34(1), 59-66.
[http://dx.doi.org/10.1111/j.1365-2036.2011.04678.x] [PMID: 21535446]
[74]
Leiman, D.A.; Riff, B.P.; Morgan, S.; Metz, D.C.; Falk, G.W.; French, B.; Umscheid, C.A.; Lewis, J.D. Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: A systematic review and meta-analysis. Dis. Esophagus, 2017, 30(2), 1-8.
[http://dx.doi.org/10.1093/dote/dow020] [PMID: 27671545]
[75]
Abbas, G.; Hanif, M.; Khan, M.A. pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design. Des. Monomers Polym., 2016, 20(1), 1-9.
[http://dx.doi.org/10.1080/15685551.2016.1231046] [PMID: 29491774]
[76]
Abbas, G.; Hanif, M. pH-Sensitive pectin polymeric rafts for controlled-release delivery of pantoprazole sodium sesquihydrate. J. Appl. Polym. Sci., 2016, 134(6)
[http://dx.doi.org/10.1002/app.44442]
[77]
Moganti, M.; Shivakumar, H.N. Oral raft forming in situ gelling system for site specific delivery of calcium. J. Drug Deliv. Sci. Technol., 2021, 61, 61.
[http://dx.doi.org/10.1016/j.jddst.2020.102113]
[78]
Kwiecien, S.; Magierowski, M.; Majka, J.; Ptak-Belowska, A.; Wojcik, D.; Sliwowski, Z.; Magierowska, K.; Brzozowski, T. Curcumin: A potent protectant against esophageal and gastric disorders. Int. J. Mol. Sci., 2019, 20(6), 1477.
[http://dx.doi.org/10.3390/ijms20061477] [PMID: 30909623]
[79]
Thavorn, K.; Mamdani, M.M.; Straus, S.E. Efficacy of turmeric in the treatment of digestive disorders: A systematic review and meta-analysis protocol. Syst. Rev., 2014, 3(1), 71.
[http://dx.doi.org/10.1186/2046-4053-3-71] [PMID: 24973984]
[80]
Kerdsakundee, N.; Mahattanadul, S.; Wiwattanapatapee, R. Physicochemical characterization of raftforming delivery systems for curcumin formulated using polysaccharide hydrogel. Lat. Am. J. Pharm., 2018, 37(4), 699-707.

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