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Anti-Infective Agents

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ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

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Research Article

Impact of Viral Load Suppression on CD4 + T-cell Count and BMI Following Combine Antiretroviral Therapy (cART) in HIV-1 Infected Individuals: Preliminary Findings in a Resource Poor Setting

Author(s): Olayemi Balogun, Bukhari Isah Shuaib, Usman Abdulrasheed Usman* and Aminu Abba Yusuf

Volume 20, Issue 5, 2022

Published on: 06 September, 2022

Article ID: e020622205560 Pages: 10

DOI: 10.2174/1573404819666220602110733

Price: $65

Abstract

Background: Immunological CD4+ T cell gain is representative of an effective response to combined antiretroviral therapy (cART) in HIV-infected persons. Nevertheless, baseline clinical and socio-demographic factors are significant moderators of this response.

Objective: This study investigates the impact of viral suppression on immune reconstitution and body mass index (BMI) following ART initiation in Zaria, a resource-poor subpopulation in Northwestern Nigeria.

Methods: A hospital-based prospective study was conducted among 44 cART-naïve HIVpositive individuals. BMI, CD4 counts, and viral load were measured using standard methods at baseline and six months after initiation of cART.

Results: There was no significant difference in the CD4+ T-cell count at baseline and 6 months on cART along with the different categories (C: < 200 cells/mm3, B: 200-499 cell/mm3, A: >500 cell/mm3). However, ~90% of subjects in category C had immunological failure 6 months on cART. The number of subjects with viral copies < 1000/ml at baseline was 7(16%), while at 6 months on cART, the number increased to 35(80%), P<0.05. Viral suppression (VL copies <1000/ml) was significantly correlated with immune recovery (CD4 count > 200 cell/mm3) in obese individuals (P<0.02). There was a significant association between subjects with CD4+ count < 200 cells/mm3 after 6 months on ART and having baseline VL copies of <1000/ml and low BMI (aOR 2.2 and 2.4 respectively, p≤0.05).

Conclusion: Findings from this study suggest a high prevalence of paradoxical VL suppression but not immune CD4 gain in the studied subjects following cART. Larger studies are needed to corroborate these findings.

Keywords: CD4+ T-cell count, Viral Load, BMI, ART, HIV-1

Graphical Abstract

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