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Current Traditional Medicine

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ISSN (Online): 2215-0846

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Hippophae salicifolia D. Don, a Fascinating Medicinal Plant: An Update on its Traditional Medicinal Uses, Ethnopharmacology and Phytochemistry

Author(s): Soni Ranjana, Alok Goyal, Gopabandhu Jena, Kulbhushan Tikoo, Arvind K. Bansal, Inder Pal Singh and Sanjay M. Jachak*

Volume 9, Issue 2, 2023

Published on: 06 September, 2022

Article ID: e270522205357 Pages: 14

DOI: 10.2174/2215083808666220527144311

Price: $65

Abstract

Hippophae salicifolia, belonging to the family Elaeagnaceae, is a thorny shrub, and shows actinorhizal habit. The species prefers a habitat of temperate regions in Europe and Asia. In India, it is distributed in the Himalayan region of Uttarakhand, Himachal Pradesh, Jammu and Kashmir, and the North-Eastern parts. The oil, fruits, leaves, and bark of Hippophae species have a pronounced use in ethnomedicines, nutritional food, cosmetics, nitrogen-fixing in soil, water conservation and as a fuel source. The aim of this review is to provide updated, comprehensive, and classified information on the traditional uses, phytochemistry, pharmacological and toxicological research carried out on H. salicifolia. This will help researchers to explore its therapeutic potential and examine future research possibilities. The chemical composition of this shrub comprises minerals, vitamins, flavonoids, flavonoids glycosides, polyunsaturated fatty acids, sugars, carotenoids, and nucleobases. Pharmacological studies demonstrated that the extracts prepared from leaves, barks, and berries along with fixed oil of this species are useful as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-depressant, anti-microbial, adaptogenic, and wound healing agent. The results of the toxicity study of H. salicifolia extracts did not show any significant acute toxicity in experimental animals. The abundance of phenolic compounds, minerals, and fatty acids within the different parts of this plant prompted researchers to isolate and characterize the phytoconstituents which are responsible for its therapeutic uses.

Keywords: Sea buckthorn, Hippophae, Hippophae salicifolia, traditional medicine, pharmacological activities, phytoconstituents.

[1]
Bhutani KK, Gohil VM. Natural products drug discovery research in India: Status and appraisal. Indian J Exp Biol 2010; 48(3): 199-207.
[PMID: 21046972]
[2]
Strohl WR. The role of natural products in a modern drug discovery program. Drug Discov Today 2000; 5(2): 39-41.
[http://dx.doi.org/10.1016/S1359-6446(99)01443-9] [PMID: 10652450]
[3]
Matias EFF, Alves EF, Santos BS, et al. Biological activities and chemical characterization of Cordia verbenacea DC. as tool to validate the ethnobiological usage. Evid Based Complement Alternat Med 2013; 2013: 164215.
[4]
Chen ST, Dou J, Temple R, Agarwal R, Wu KM, Walker S. New therapies from old medicines. Nat Biotechnol 2008; 26(10): 1077-83.
[http://dx.doi.org/10.1038/nbt1008-1077] [PMID: 18846070]
[5]
Mishra BB, Tiwari VK. Natural products: An evolving role in future drug discovery. Eur J Med Chem 2011; 46(10): 4769-807.
[http://dx.doi.org/10.1016/j.ejmech.2011.07.057] [PMID: 21889825]
[6]
Grover J, Jachak SM. Recent developments in chemistry and biology of curcumin analogues. RSC Advances 2014; 4(27): 13946.
[http://dx.doi.org/10.1039/c4ra00227j]
[7]
Yusuf M, Sadiya M, Ahmed B, Gulfishan M. Modern perspectives of curcumin and its derivatives as promising bioactive and pharmaceutical Agents. Biointerface Res Appl Chem 2022; 12: 7024-177.
[8]
Khanal P, Chawla U, Praveen S, et al. Study of naturally-derived biomolecules as therapeutics against SARS-CoV-2 viral spike protein. J Pharm Res Int 2021; 33: 211-20.
[http://dx.doi.org/10.9734/jpri/2021/v33i28A31524]
[9]
Yusuf M, Aijaz M, Keserwani N, Ansari NH, Khan SA. Ethnomedicinal, pharmacological and commercial perspectives of laccifer lacca body exudate (LBE). Lett Appl NanoBioScience 2023; 12.
[10]
Malani RS, Malshe VC, Thorat BN. Polyols and polyurethanes from renewable sources: Past, present and future-part 1: Vegetable oils and lignocellulosic biomass. J Coat Technol Res 2021; 19: 1-15.
[11]
Sharma A, Singh V, Sharma A, Negi N. Sea buckthorn a new approach in ecological restoration of Himalayan ecosystem: A review. Int J Chem Stud 2019; 7: 1219-26.
[12]
Pant M, Lal A, Rani A. Hippophae salicifolia D Don- A plant with multifarious benefits. Int J Pharm Pharm Sci 2014; 6: 9-12.
[13]
Singh IP, Ahmad F, Gore DD, et al. Expert opinion on therapeutic potential of sea buckthorn  A patent review. Expert Opin Ther Pat 2019; 29: 1-12.
[http://dx.doi.org/10.1080/13543776.2019.1648434]
[14]
Mingyu X, Xiaoxuan S, Jinhua C. The medicinal research and development of sea buckthorn. J Soil Water Conserv 1993; 5: 1-11.
[15]
Gupta SM, Ahmed Z. Sea buckthorn (Hippophae salicifolia L.) plant  As source donor of cold tolerant genes for improving high altitude agriculture during cold stress. Res Environ Life Sci 2010; 3: 105-12.
[16]
Basistha BC, Sharma NP, Lepcha L, Arrawatia ML, Sen A. Ecology of Hippophae salicifolia D. Don of temperate and sub-alpine forests of North Sikkim Himalayas - a case study. Symbiosis 2010; 50(1-2): 87-95.
[http://dx.doi.org/10.1007/s13199-009-0033-y]
[17]
Thomas SC, Schroeder WR. Sea buckthorn (Hippophae rhamnoides L.): A multipurpose plant. Horttechnology 1996; 6(4): 370-80.
[http://dx.doi.org/10.21273/HORTTECH.6.4.370]
[18]
Dhyani D, Maikhuri RK, Misra S, Rao KS. Endorsing the declining indigenous ethnobotanical knowledge system of sea buckthorn in Central Himalaya, India. J Ethnopharmacol 2010; 127(2): 329-34.
[http://dx.doi.org/10.1016/j.jep.2009.10.037] [PMID: 19900529]
[19]
Panossian A, Wagner H. From traditional to evidence-based use of Hippophae rhamnoides L. chemical composition, experimental, and clinical pharmacology of sea buckthorn berries and leaves extracts. 2013; pp. 181-236.
[20]
Koskovac M, Cupara S, Kipic M, et al. Sea buckthorn oil - a valuable source for cosmeceuticals. Cosmetics 2017; 4(4): 40.
[http://dx.doi.org/10.3390/cosmetics4040040]
[21]
Yang B, Kallio H. Composition and physiological effects of sea buckthorn (Hippophae) lipids. Trends Food Sci Technol 2002; 13(5): 160-7.
[http://dx.doi.org/10.1016/S0924-2244(02)00136-X]
[22]
Bal LM, Meda V, Naik SN, Satya S. Sea buckthorn berries: A potential source of valuable nutrients for nutraceuticals and cosmoceuticals. Food Res Int 2011; 44(7): 1718-27.
[http://dx.doi.org/10.1016/j.foodres.2011.03.002]
[23]
Kallio H, Yang B, Peippo P. Effects of different origins and harvesting time on vitamin C, tocopherols, and tocotrienols in sea buckthorn (Hippophaë rhamnoides) berries. J Agric Food Chem 2002; 50(21): 6136-42.
[http://dx.doi.org/10.1021/jf020421v] [PMID: 12358492]
[24]
Makinen KK, Soderling E. A quantitative study of mannitol, sorbitol, xylitol, and xylose in wild berries and commercial fruits. J Food Sci 1980; 45(2): 367-71.
[http://dx.doi.org/10.1111/j.1365-2621.1980.tb02616.x]
[25]
Yang B, Karlsson RM, Oksman PH, Kallio HP. Phytosterols in sea buckthorn (Hippophaë rhamnoides L.) berries: Identification and effects of different origins and harvesting times. J Agric Food Chem 2001; 49(11): 5620-9.
[http://dx.doi.org/10.1021/jf010813m] [PMID: 11714369]
[26]
Johansson A, Laakso P, Kallio H. Characterization of seed oils of wild, edible Finnish berries. Eur Food Res Technol 1997; 204: 300-7.
[27]
Andersson SC, Olsson ME, Johansson E, Rumpunen K. Carotenoids in sea buckthorn (Hippophae rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker. J Agric Food Chem 2009; 57(1): 250-8.
[http://dx.doi.org/10.1021/jf802599f] [PMID: 19125686]
[28]
Pop RM, Weesepoel Y, Socaciu C, Pintea A, Vincken JP, Gruppen H. Carotenoid composition of berries and leaves from six Romanian sea buckthorn (Hippophae rhamnoides L.) varieties. Food Chem 2014; 147: 1-9.
[http://dx.doi.org/10.1016/j.foodchem.2013.09.083] [PMID: 24206678]
[29]
Upadhyay NK, Kumar MSY, Gupta A. Antioxidant, cytoprotective and antibacterial effects of Sea buckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol 2010; 48(12): 3443-8.
[http://dx.doi.org/10.1016/j.fct.2010.09.019] [PMID: 20854873]
[30]
Geetha S, Singh V, Ram MS, Ilavazhagan G, Banerjee PK, Sawhney RC. Immunomodulatory effects of sea buckthorn (Hippophae rhamnoides L.) against chromium (VI) induced immunosuppression. Mol Cell Biochem 2005; 278(1-2): 101-9.
[http://dx.doi.org/10.1007/s11010-005-7095-9] [PMID: 16180095]
[31]
Tulsawani R. Ninety day repeated gavage administration of Hipphophae rhamnoides extract in rats. Food Chem Toxicol 2010; 48(8-9): 2483-9.
[http://dx.doi.org/10.1016/j.fct.2010.06.018] [PMID: 20558226]
[32]
Kumar IP, Namita S, Goel HC. Modulation of chromatin organization by RH-3, a preparation of Hippophae rhamnoides, a possible role in radioprotection. Mol Cell Biochem 2002; 238(1-2): 1-9.
[http://dx.doi.org/10.1023/A:1019905211392] [PMID: 12349895]
[33]
Airi S, Bhatt ID, Bhatt A, Rawal RS, Dhar U. Variations in seed germination of Hippophae salicifolia with different pre- soaking treatments. J For Res 2009; 20(1): 27-30.
[http://dx.doi.org/10.1007/s11676-009-0005-3]
[34]
Rana D. Gourav. Vertical characterization of soil under sea buckthorn (Hippophaesalicifolia L.) in relation to age for sustainable development of cold arid Himalayas. Int J Chem Stud 2018; 6: 1362-9.
[35]
Dincă L, Holonec L, Socaciu C, et al. Hippophae salicifolia D. Don : A miraculous species less known in Europe. Not Bot Horti Agrobot Cluj-Napoca 2018; 46(2): 474-83.
[http://dx.doi.org/10.15835/nbha46211155]
[36]
Ranjith A, Kumar KS, Venugopalan VV, Arumughan C, Sawhney RC, Singh V. Fatty acids, tocols, and carotenoids in pulp oil of three sea buckthorn species (Hippophae rhamnoides, Hippophae salicifolia, and Hippophae tibetana) grown in the Indian Himalayas. J Am Oil Chem Soc 2006; 83: 359-64.
[http://dx.doi.org/10.1007/s11746-006-1213-z]
[37]
Beveridge T, Li TSC, Oomah BD, Smith A. Sea buckthorn products: Manufacture and composition. J Agric Food Chem 1999; 47(9): 3480-8.
[http://dx.doi.org/10.1021/jf981331m] [PMID: 10552673]
[38]
Rakshit P, Shweta G, Kumari A. Antioxidant profiling and fatty acid composition of lipids present in Hippophae salicifolia grown in higher altitude of Uttarakhand region. World J Pharm Res 2018; 7: 1286-97.
[39]
Goyal AK, Basistha BC, Sen A, Middha SK. Antioxidant profiling of Hippophae salicifolia growing in sacred forests of Sikkim, India. Funct Plant Biol 2011; 38(9): 697-701.
[http://dx.doi.org/10.1071/FP11016] [PMID: 32480925]
[40]
Gupta SM, Gupta A, Ahmed Z, Kumar A. Antibacterial and antifungal activity in leaf, seed extract and seed oil of sea buckthorn (Hippophae salicifolia D. Don) plant. J Plant Pathol Microbiol 2011; 2: 2-5.
[41]
Moudgil AD, Mittra S, Sen D, Agnihotri RK, Sharma D. Biochemical and leucocytic response study of herbal immunomodulators against levamisole in toxocara canis infected mice biochemical and leucocytic response study of herbal immunomodulators against levamisole in toxocara canis infected mice. ARCC 2015; 49: 336-42.
[42]
Usha T, Middha SK, Goyal AK, et al. Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia. J Biomed Res 2014; 28(5): 406-15.
[PMID: 25332713]
[43]
Singh PK, Gupta VK, Roy S. Wound healing potential of Hippophae salicifolia bark extract in rats. Bull Env Pharmacol Life Sci 2017; 6: 98-102.
[44]
Suleyman H, Gumustekin K, Taysi S, et al. Beneficial effects of Hippophae rhamnoides L. on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull 2002; 25(9): 1133-6.
[http://dx.doi.org/10.1248/bpb.25.1133] [PMID: 12230103]
[45]
Zeb A. Important therapeutiic uses of sea buckthorn (Hippophae): A review. J Biol Sci (Faisalabad, Pak) 2004; 4(5): 687-93.
[http://dx.doi.org/10.3923/jbs.2004.687.693]
[46]
Negi PS, Chauhan AS. Antioxidant and antibacterial activities of various sea buckthorn (Hippophae rhamnoides L.) seed extracts. Food Chem 2005; 92: 119-224.
[http://dx.doi.org/10.1016/j.foodchem.2004.07.009]
[47]
Mamedov N, Gardner Z, Craker LE, Craker LE. Medicinal plants used in Russia and central Asia for the treatment of selected skin conditions. J Herbs Spices Med Plants 2008; 6475: 191-222.
[48]
Cakir A. Essential oil and fatty acid composition of the fruits of Hippophae rhamnoides L. (Sea Buckthorn) and Myrtus communis L. from Turkey. Biochem Syst Ecol 2004; 32(9): 809-16.
[http://dx.doi.org/10.1016/j.bse.2003.11.010]
[49]
Uprety Y, Asselin H, Boon EK, Yadav S, Shrestha KK. Indigenous use and bio-efficacy of medicinal plants in the Rasuwa district, central Nepal. J Ethnobiol Ethnomed 2010; 6(1): 3.
[http://dx.doi.org/10.1186/1746-4269-6-3] [PMID: 20102631]
[50]
Guliyev VB, Gul M, Yildirim A. Hippophae rhamnoides L.: Chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. J Chromatogr B Analyt Technol Biomed Life Sci 2004; 812(1-2): 291-307.
[http://dx.doi.org/10.1016/S1570-0232(04)00720-2] [PMID: 15556505]
[51]
Tian Y, Liimatainen J, Alanne AL, et al. Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. Food Chem 2017; 220: 266-81.
[http://dx.doi.org/10.1016/j.foodchem.2016.09.145] [PMID: 27855899]
[52]
Liu Y, Fan G, Zhang J, et al. Metabolic discrimination of sea buckthorn from different Hippophaë species by 1H NMR based metabolomics. Sci Rep 2017; 7(1): 1585-95.
[http://dx.doi.org/10.1038/s41598-017-01722-3] [PMID: 28484246]
[53]
Kim JS, Kwon YS, Sa YJ, Kim MJ. Isolation and identification of sea buckthorn (Hippophae rhamnoides) phenolics with antioxidant activity and α-glucosidase inhibitory effect. J Agric Food Chem 2011; 59(1): 138-44.
[http://dx.doi.org/10.1021/jf103130a] [PMID: 21142100]
[54]
Dong R, Su J, Nian H, et al. Chemical fingerprint and quantitative analysis of flavonoids for quality control of Sea buckthorn leaves by HPLC and UHPLC-ESI-QTOF-MS. J Funct Foods 2017; 37: 513-22.
[http://dx.doi.org/10.1016/j.jff.2017.08.019]
[55]
Sharma P, Kirar V, Suryakumar G, Misra K. Phytochemical analysis of Sea buckthorn extracts and quantification of flavonoids by HPTLC. Biochem Pharmacol 2013; 2: 4172.
[56]
Kapoor L, Srivastava S, Singh S, Kapoor S, Shah N. Survey of Indian plants for saponins, alkaloids and flavonoids. III. Lloydia 1972; 35: 288-95.
[57]
Kaushal M, Sharma P. Nutritional and antimicrobial property of sea buckthorn (Hippophae sp.) seed oil. J Sci Ind Res (India) 2011; 70: 1033-6.
[58]
Dubey S, Ramana MV, Mishra A. Comparison of fatty acid profiling and RBC membrane stabilization activity of sea buckthorn (Hippophae rhamnoides and Hippophae salicifolia) seed oil. Pharmacogn J 2017; 9(3): 329-35.
[http://dx.doi.org/10.5530/pj.2017.3.56]
[59]
Jansson PE, Kenne L, Liedgren H, Lindberg B, Lonngren J. A practical guide to the methylation analysis of carbohydrates. ChemComm 1976; 8: 1-76.
[60]
Kumar V, Naudiyal M, Dubey P. Acidic and neutral monosaccharide analysis of cold water soluble acidic and neutral monosaccharide analysis of cold water soluble polysaccharide from Hippophae salicifolia D. Don Leaves. J Bio Act Prod Nat 2017; 7: 27-33.
[61]
Krokan HE, Drabløs F, Slupphaug G. Uracil in DNA--occurrence, consequences and repair. Oncogene 2002; 21(58): 8935-48.
[http://dx.doi.org/10.1038/sj.onc.1205996] [PMID: 12483510]
[62]
Asimakis GK, Conti VR. Myocardial ischemia: Correlation of mitochondrial adenine nucleotide and respiratory function. J Mol Cell Cardiol 1984; 16(5): 439-47.
[http://dx.doi.org/10.1016/S0022-2828(84)80615-X] [PMID: 6737484]
[63]
Mishra J, Hande P, Sharma P, Bhardwaj A, Misra K. Characterization of nucleobases in sea buckthorn leaves: An HPTLC approach. J Liq Chromatogr Relat Technol 2017; 40(1): 50-7.
[http://dx.doi.org/10.1080/10826076.2017.1283517]
[64]
Saikia M, Handique PJ. Antioxidant and antibacterial activity of leaf, bark, pulp and seed extracts of sea buckthorn (Hippophae salicifolia D. Don) of Sikkim Himalayas. J Med Plants Res 2013; 7: 1330-8.
[65]
Chakraborty M, Karmakar I, Haldar S, Das A, Bala A, Haldar PK. Amelioration of oxidative DNA damage in mouse peritoneal macrophages by Hippophae salicifolia due to its proton (H(+)) donation capability: Ex vivo and in vivo studies. J Pharm Bioallied Sci 2016; 8(3): 210-6.
[http://dx.doi.org/10.4103/0975-7406.172663] [PMID: 27413349]
[66]
Middha SK, Goyal AK, Faizan SA, Sanghamitra N, Basistha BC, Usha T. In silico -based combinatorial pharmacophore modelling and docking studies of GSK-3β and GK inhibitors of Hippophae. J Biosci 2013; 38(4): 805-14.
[http://dx.doi.org/10.1007/s12038-013-9367-y] [PMID: 24287660]
[67]
Midha SK, Usha T, Basistha BC, Goyal AK. Amelioration of antioxidant potential, toxicity, and antihyperglycemic activity of Hippophae salicifolia D. Don leaf extracts in alloxan induced diabetic rats 3. Biotech 2019; 9: 308-16.
[68]
Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res 1995; 44(1): 1-10.
[http://dx.doi.org/10.1007/BF01630479] [PMID: 7664022]
[69]
Saso L, Valentini G, Casini ML, et al. Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: A new hypothesis for the mechanism of action of fish oil in rheumatic diseases. Jpn J Pharmacol 1999; 79: 89-99.
[70]
Dubey S, Ramana MV, Mishra A, Gupta PS, Awasthi H. Sea buckthorn (Hippophae rhamnoides and Hippophae salicifolia) seed oil in combating inflammation  A mechanistic approach. Pharmacognosy Res 2018; 10(4): 404-7.
[http://dx.doi.org/10.4103/pr.pr_71_18]
[71]
Opie EL. On the relation of necrosis and inflammation to denaturation of proteins. J Exp Med 1962; 115(3): 597-608.
[http://dx.doi.org/10.1084/jem.115.3.597] [PMID: 14482110]
[72]
Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl) 1985; 85(3): 367-70.
[http://dx.doi.org/10.1007/BF00428203] [PMID: 3923523]
[73]
Thakur SR, Kandalaneela M, Mogarayulu P, Yadikar L. Implication of adrenergic, serotonergic and antioxidant systems in the antidepressant activity of Hippophae salicifolia D. Don. Curr Trends Biotechnol Pharm 2015; 9: 59-67.
[74]
Chakraborty M, Karmakar I, Haldar S, Nepal A. Anticancer and antioxidant activity of methanol extract of Hippophae salicifolia in EAC induced Swiss albino mice. Int J Pharm Pharm Sci 2015; 7: 180-4.
[75]
Ramachandran U, Divekar HM, Grover SK, Srivastava KK. New experimental model for the evaluation of adaptogenic products. J Ethnopharmacol 1990; 29(3): 275-81.
[http://dx.doi.org/10.1016/0378-8741(90)90038-U] [PMID: 2214813]
[76]
Gupta SM, Grover A, Pandey P, Ahmed Z. Female plants of Hippophae salicifolia D. Don are more responsive to cold stress than male plants. Physiol Mol Biol Plants 2012; 18(4): 377-80.
[http://dx.doi.org/10.1007/s12298-012-0133-7] [PMID: 24082501]
[77]
Sharma P, Suryakumar G, Singh V, Misra K, Singh SB. In vitro antioxidant profiling of sea buckthorn varieties and their adaptogenic response to high altitude-induced stress. Int J Biometeorol 2015; 59(8): 1115-26.
[http://dx.doi.org/10.1007/s00484-014-0925-2] [PMID: 25384585]
[78]
Rathor R, Sharma P, Suryakumar G, Ganju L. A pharmacological investigation of Hippophae salicifolia (HS) and Hippophae rhamnoides turkestanica (HRT) against multiple stress (C-H-R): An experimental study using rat model. Cell Stress Chaperones 2015; 20(5): 821-31.
[http://dx.doi.org/10.1007/s12192-015-0603-2] [PMID: 26045201]
[79]
Gupta A, Kumar R, Pal K, Banerjee PK, Sawhney RC. A preclinical study of the effects of sea buckthorn (Hippophae rhamnoides L.) leaf extract on cutaneous wound healing in albino rats. Int J Low Extrem Wounds 2005; 4(2): 88-92.
[http://dx.doi.org/10.1177/1534734605277401] [PMID: 15911921]
[80]
Kim J, Lee CM. Wound healing potential of a polyvinyl alcohol-blended pectin hydrogel containing Hippophae rahmnoides L. extract in a rat model. Int J Biol Macromol 2017; 99: 586-93.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.03.014] [PMID: 28283451]
[81]
OECD. Test guideline 425: Acute oral toxicity- up-and-down procedure. OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris. 2008.
[82]
Ramu S, Krishnaraj K, Devika A, Murali A. Protective effects of Hippophae salicifolia D. Don fruit pulp extract in aluminium toxicity. Spat DD 2014; 4(4): 207-12.
[http://dx.doi.org/10.5455/spatula.20141103125759]
[83]
Kumari R, Agrawal A, Ii K. GPI, S.; GP. D. In vivo evaluation of the antidepressant activity of a novel polyherbal formulation. Autism 2021; 6: 194-201.
[84]
Kumari R, Agrawal A, Dubey GP, Ilango K, Singh PK, Singh GP. Safety evaluation of a polyherbal formulation containing hydroalcoholic extracts of Hippophae salicifolia, Nyctanthes arbor-tristis, Ocimum tenuiflorum, and Reinwardtia indica in rodents. J Biomed Res 2016; 30(3): 248-50.
[PMID: 27533935]

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