Abstract
Aim: This systematic review aimed to appraise and recapitulate all research investigations to elucidate the effects of Sesamum indicum preparations on managing the cardiometabolic syndrome of Diabetes mellitus (DM) and metabolic syndrome (MetS).
Methods: A systematic review was carried out in a Cochrane fashion and in compliance with the PRISMA checklist using the published academic works in PubMed/MEDLINE, WOS, SCOPUS, and EMBASE databases that were searched up to June 2021. Abstracts that met PICO criteria for qualitative studies were duplicate reviewed for data extraction to assess the quality and details of the study.
Results: Sesamum indicum preparations and its bioactive lignans, such as sesamin, sesamol, and pinoresinol, were found to possess anti-hyperglycemic, anti-hyperlipidemia, anti-inflammatory, antioxidative, anti-hypertensive, cardioprotective, and hepatoprotective effects both in patients with T2DM as well as in experimental animal models with T1DM and MetS. The incorporation of sesame oil as a natural adjuvant can be effective in improving vascular reactivity and aortic permeability, reproductive parameters, and diabetic nephropathy, as well as modification of anthropometry indices. Therefore, sesame oil and bioactive lignans as combination therapy with drugs can exhibit synergistic effects and provide a favorable preference in clinical settings.
Conclusion: Sesame oil and lignans present in it act in a dose-dependent manner. The best dosage to improve risk biomarkers of patients with T2DM and MetS is 30-35 ml daily of sesame oil or inclusion of sesame oil in daily dietary patterns up to 30% of total energy for 8-12 weeks and/or 200 mg daily of sesamin supplementation for eight weeks.
Keywords: Sesame preparations, bioactive ingredients, cardiometabolic syndrome, therapeutic effectiveness, diabetic patients, coronary artery disease.
[1]
Miura SI, Shiga Y, Ike A, Iwata A. Atherosclerotic coronary artery disease in patients with cardiometabolic syndrome. Cardiol Res 2019; 10(2): 69-73.
[http://dx.doi.org/10.14740/cr857] [PMID: 31019635]
[http://dx.doi.org/10.14740/cr857] [PMID: 31019635]
[2]
Blom DJ, Santos RD, Daclin V, Mercier F, Ruiz AJ, Danchin N. The challenge of multiple cardiovascular risk factor control outside Western Europe: Findings from the International ChoLesterol management Practice Study. Eur J Prev Cardiol 2020; 27(13): 1403-11.
[http://dx.doi.org/10.1177/2047487319871735] [PMID: 31533447]
[http://dx.doi.org/10.1177/2047487319871735] [PMID: 31533447]
[3]
Lee MY, Hsiao PJ, Huang JC, Hsu WH, Chen SC, Shin SJ. Association between metabolic syndrome and microvascular and macrovascular disease in type 2 diabetic mellitus. Am J Med Sci 2018; 355(4): 342-9.
[http://dx.doi.org/10.1016/j.amjms.2017.12.004] [PMID: 29661347]
[http://dx.doi.org/10.1016/j.amjms.2017.12.004] [PMID: 29661347]
[4]
Chen YC, Hsu BG, Wang JH, Lee CJ, Tsai JP. Metabolic syndrome with aortic arterial stiffness and first hospitalization or mortality in coronary artery disease patients. Diabetes Metab Syndr Obes 2019; 12: 2065-73.
[http://dx.doi.org/10.2147/DMSO.S218718] [PMID: 31632116]
[http://dx.doi.org/10.2147/DMSO.S218718] [PMID: 31632116]
[5]
Matsuzawa Y, Lerman A. Endothelial dysfunction and coronary artery disease: Assessment, prognosis, and treatment. Coron Artery Dis 2014; 25(8): 713-24.
[http://dx.doi.org/10.1097/MCA.0000000000000178] [PMID: 25365643]
[http://dx.doi.org/10.1097/MCA.0000000000000178] [PMID: 25365643]
[6]
Ravera A, Carubelli V, Sciatti E, et al. Nutrition and cardiovascular disease: Finding the perfect recipe for cardiovascular health. Nutrients 2016; 8(6): 363.
[http://dx.doi.org/10.3390/nu8060363] [PMID: 27314382]
[http://dx.doi.org/10.3390/nu8060363] [PMID: 27314382]
[7]
Wali JA, Jarzebska N, Raubenheimer D, Simpson SJ, Rodionov RN, O’Sullivan JF. Cardio-metabolic effects of high-fat diets and their underlying mechanisms-a narrative review. Nutrients 2020; 12(5): 1505.
[http://dx.doi.org/10.3390/nu12051505] [PMID: 32455838]
[http://dx.doi.org/10.3390/nu12051505] [PMID: 32455838]
[8]
Lin YC, Thùy TD, Wang SY, Huang PL. Type 1 diabetes, cardiovascular complications and sesame (zhī má). J Tradit Complement Med 2014; 4(1): 36-41.
[http://dx.doi.org/10.4103/2225-4110.124817] [PMID: 24872931]
[http://dx.doi.org/10.4103/2225-4110.124817] [PMID: 24872931]
[9]
Katsuzaki H, Osawa T, Kawakishi S. Chemistry and antioxidative activity of lignan glucosides in sesame seed ACS Symp Ser. 1994; p. 574: 275-80.
[http://dx.doi.org/10.1021/bk-1994-0547.ch028]
[http://dx.doi.org/10.1021/bk-1994-0547.ch028]
[10]
Katsuzaki H, Kawakishi S, Osawa T. Sesaminol glucosides in sesame seeds. Phytochemistry 1994; 35(3): 773-6.
[http://dx.doi.org/10.1016/S0031-9422(00)90603-4] [PMID: 7764592]
[http://dx.doi.org/10.1016/S0031-9422(00)90603-4] [PMID: 7764592]
[11]
Moazzami AA, Andersson RE, Kamal-Eldin A. HPLC analysis of sesaminol glucosides in sesame seeds. J Agric Food Chem 2006; 54(3): 633-8.
[http://dx.doi.org/10.1021/jf051541g] [PMID: 16448160]
[http://dx.doi.org/10.1021/jf051541g] [PMID: 16448160]
[12]
Gouveia LA, Cardoso CA, de Oliveira GMM, Rosa G, Moreira ASB. Effects of the intake of sesame seeds (Sesamum indicum L.) and derivatives on oxidative stress: A systematic review. J Med Food 2016; 19(4): 337-45.
[http://dx.doi.org/10.1089/jmf.2015.0075] [PMID: 27074618]
[http://dx.doi.org/10.1089/jmf.2015.0075] [PMID: 27074618]
[13]
Bosebabu B, Cheruku SP, Chamallamudi MR, et al. An appraisal of current pharmacological perspectives of sesamol: A review. Mini Rev Med Chem 2020; 20(11): 988-1000.
[http://dx.doi.org/10.2174/1389557520666200313120419] [PMID: 32167426]
[http://dx.doi.org/10.2174/1389557520666200313120419] [PMID: 32167426]
[14]
Namiki M. Nutraceutical functions of sesame: A review. Crit Rev Food Sci Nutr 2007; 47(7): 651-73.
[http://dx.doi.org/10.1080/10408390600919114] [PMID: 17943496]
[http://dx.doi.org/10.1080/10408390600919114] [PMID: 17943496]
[15]
Kamal-Eldin A, Moazzami A, Washi S. Sesame seed lignans: Potent physiological modulators and possible ingredients in functional foods & nutraceuticals. Recent Pat Food Nutr Agric 2011; 3(1): 17-29.
[http://dx.doi.org/10.2174/2212798411103010017] [PMID: 21114470]
[http://dx.doi.org/10.2174/2212798411103010017] [PMID: 21114470]
[16]
VanGilder RL, Huber JD. Sesamol: A treatment for diabetes-associated blood-brain barrier dysfunction. Postdoc J 2014; 2(7): 13-22.
[http://dx.doi.org/10.14304/SURYA.JPR.V2N7.2] [PMID: 28781979]
[http://dx.doi.org/10.14304/SURYA.JPR.V2N7.2] [PMID: 28781979]
[17]
Maideen NMP, Balasubramaniam R. Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs. J Herb Med Pharmacol 2018; 7(3): 200-10.
[http://dx.doi.org/10.15171/jhp.2018.32]
[http://dx.doi.org/10.15171/jhp.2018.32]
[18]
Clifton PM. Diet, exercise and weight loss and dyslipidaemia. Pathology 2019; 51(2): 222-6.
[http://dx.doi.org/10.1016/j.pathol.2018.10.013] [PMID: 30528924]
[http://dx.doi.org/10.1016/j.pathol.2018.10.013] [PMID: 30528924]
[19]
Kim AY, Yun CI, Lee JG, Kim YJ. Determination and daily intake estimation of lignans in sesame seeds and sesame oil products in Korea. Foods 2020; 9(4): 394.
[http://dx.doi.org/10.3390/foods9040394] [PMID: 32235516]
[http://dx.doi.org/10.3390/foods9040394] [PMID: 32235516]
[20]
Mustafa RA, Santesso N, Brozek J, et al. The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses. J Clin Epidemiol 2013; 66(7): 736-42.
[http://dx.doi.org/10.1016/j.jclinepi.2013.02.004] [PMID: 23623694]
[http://dx.doi.org/10.1016/j.jclinepi.2013.02.004] [PMID: 23623694]
[21]
Farajbakhsh A, Mazloomi SM, Mazidi M, et al. Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: A randomized clinical trial. Eur J Clin Nutr 2019; 73(10): 1403-11.
[http://dx.doi.org/10.1038/s41430-019-0438-5] [PMID: 31089253]
[http://dx.doi.org/10.1038/s41430-019-0438-5] [PMID: 31089253]
[22]
Aslam F, Iqbal S, Nasir M, Anjum AA. White sesame seed oil mitigates blood glucose level, reduces oxidative stress, and improves biomarkers of hepatic and renal function in participants with type 2 diabetes mellitus. J Am Coll Nutr 2019; 38(3): 235-46.
[http://dx.doi.org/10.1080/07315724.2018.1500183] [PMID: 30260748]
[http://dx.doi.org/10.1080/07315724.2018.1500183] [PMID: 30260748]
[23]
Raeisi-Dehkordi H, Amiri M, Zimorovat A, et al. Canola oil compared with sesame and sesame-canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three-way randomized triple-blind cross-over trial. Diabetes Metab Res Rev 2021; 37(5)e3399
[http://dx.doi.org/10.1002/dmrr.3399] [PMID: 32860716]
[http://dx.doi.org/10.1002/dmrr.3399] [PMID: 32860716]
[24]
Mirmiran P, Bahadoran Z, Golzarand M, Rajab A, Azizi F. Ardeh (Sesamum indicum) could improve serum triglycerides and atherogenic lipid parameters in type 2 diabetic patients: A randomized clinical trial. Arch Iran Med 2013; 16(11): 651-6.
[PMID: 24206407]
[PMID: 24206407]
[25]
Ramezani-Jolfaie N, Aghaei S, Yazd EF, et al. Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus. Clin Nutr ESPEN 2020; 38: 129-37.
[http://dx.doi.org/10.1016/j.clnesp.2020.05.016] [PMID: 32690147]
[http://dx.doi.org/10.1016/j.clnesp.2020.05.016] [PMID: 32690147]
[26]
Sankar D, Ali A, Sambandam G, Rao R. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clin Nutr 2011; 30(3): 351-8.
[http://dx.doi.org/10.1016/j.clnu.2010.11.005] [PMID: 21163558]
[http://dx.doi.org/10.1016/j.clnu.2010.11.005] [PMID: 21163558]
[27]
Sankar D, Rao MR, Sambandam G, Pugalendi KV. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food 2006; 9(3): 408-12.
[http://dx.doi.org/10.1089/jmf.2006.9.408] [PMID: 17004907]
[http://dx.doi.org/10.1089/jmf.2006.9.408] [PMID: 17004907]
[28]
Mohammad Shahi M, Zakerzadeh M, Zakerkish M, Zarei M, Saki A. Effect of sesamin supplementation on glycemic status, inflammatory markers, and adiponectin levels in patients with type 2 diabetes mellitus. J Diet Suppl 2017; 14(1): 65-75.
[http://dx.doi.org/10.1080/19390211.2016.1204404] [PMID: 27450646]
[http://dx.doi.org/10.1080/19390211.2016.1204404] [PMID: 27450646]
[29]
Wu JHY, Hodgson JM, Puddey IB, Belski R, Burke V, Croft KD. Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutr Metab Cardiovasc Dis 2009; 19(11): 774-80.
[http://dx.doi.org/10.1016/j.numecd.2009.01.003] [PMID: 19346113]
[http://dx.doi.org/10.1016/j.numecd.2009.01.003] [PMID: 19346113]
[30]
Wu JHY, Hodgson JM, Clarke MW, et al. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: In vitro and human studies. Hypertension 2009; 54(5): 1151-8.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.139352] [PMID: 19786646]
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.139352] [PMID: 19786646]
[31]
Mohammadshahi M, Zakerzadeh M, Zakerkish M, Zarei M, Saki A. Effects of sesamin on the glycemic index, lipid profile, and serum malondialdehyde level of patients with type II diabetes. Majallah-i Danishgah-i Ulum-i Pizishki-i Babul 2016; 18(6): 7-14.
[32]
Katsilambros N, Philippides P, Davoulos G, et al. Sesame-derived candies and glycaemic response in type II diabetic subjects. Diabetes Nutr Metab 1991; 4(4): 325-7.
[33]
Ramezani-Jolfaie N, Aghaei S, Farashahi Yazd E, et al. The combined effects of Cholesteryl Ester Transfer Protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people. J Cardiovasc Thorac Res 2020; 12(3): 185-94.
[http://dx.doi.org/10.34172/jcvtr.2020.32] [PMID: 33123324]
[http://dx.doi.org/10.34172/jcvtr.2020.32] [PMID: 33123324]
[34]
Haidari F, Mohammadshahi M, Zarei M, Gorji Z. Effects of sesame butter (Ardeh) versus sesame oil on metabolic and oxidative stress markers in streptozotocin-induced diabetic rats. Iran J Med Sci 2016; 41(2): 102-9.
[PMID: 26989280]
[PMID: 26989280]
[35]
Aslam F, Iqbal S, Nasir M, Anjum AA, Swan P, Sweazea K. Evaluation of white sesame seed oil on glucose control and biomarkers of hepatic, cardiac, and renal functions in male Sprague-Dawley rats with chemically induced diabetes. J Med Food 2017; 20(5): 448-57.
[http://dx.doi.org/10.1089/jmf.2016.0065] [PMID: 28332903]
[http://dx.doi.org/10.1089/jmf.2016.0065] [PMID: 28332903]
[36]
Abbasi Z, Tabatabaei SR, Mazaheri Y, Barati F, Morovvati H. Effects of sesame oil on the reproductive parameters of diabetes mellitus-induced male rats. World J Mens Health 2013; 31(2): 141-9.
[http://dx.doi.org/10.5534/wjmh.2013.31.2.141] [PMID: 24044109]
[http://dx.doi.org/10.5534/wjmh.2013.31.2.141] [PMID: 24044109]
[37]
Guo H, Ban YH, Cha Y, et al. Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats. J Biomed Res 2017; 31(2): 122-9.
[PMID: 28808194]
[PMID: 28808194]
[38]
Biasiotto G, Penza M, Zanella I, et al. Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro. Eur J Nutr 2014; 53(8): 1685-97.
[http://dx.doi.org/10.1007/s00394-014-0675-2] [PMID: 24566767]
[http://dx.doi.org/10.1007/s00394-014-0675-2] [PMID: 24566767]
[39]
Ramesh B, Saravanan R, Pugalendi KV. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food 2005; 8(3): 377-81.
[http://dx.doi.org/10.1089/jmf.2005.8.377] [PMID: 16176150]
[http://dx.doi.org/10.1089/jmf.2005.8.377] [PMID: 16176150]
[40]
Khaneshi F, Nasrolahi O, Azizi S, Nejati V. Sesame effects on testicular damage in streptozotocin-induced diabetes rats. Avicenna J Phytomed 2013; 3(4): 347-55.
[PMID: 25050292]
[PMID: 25050292]
[41]
Al-Amoudi NS, Abu Araki HA. Evaluation of vegetable and fish oils diets for the amelioration of diabetes side effects. J Diabetes Metab Disord 2013; 12(1): 13.
[http://dx.doi.org/10.1186/2251-6581-12-13] [PMID: 23497544]
[http://dx.doi.org/10.1186/2251-6581-12-13] [PMID: 23497544]
[42]
Dhar P, Chattopadhya K, Bhattacharyya D, Biswas A, Roy B, Ghosh S. Ameliorative influence of sesame lignans on lipid profile and lipid peroxidation in induced diabetic rats. J Agric Food Chem 2007; 55(14): 5875-80.
[http://dx.doi.org/10.1021/jf063721b] [PMID: 17571897]
[http://dx.doi.org/10.1021/jf063721b] [PMID: 17571897]
[43]
Farbood Y, Ghaderi S, Rashno M, et al. Sesamin: A promising protective agent against diabetes-associated cognitive decline in rats. Life Sci 2019; 230: 169-77.
[http://dx.doi.org/10.1016/j.lfs.2019.05.071] [PMID: 31150685]
[http://dx.doi.org/10.1016/j.lfs.2019.05.071] [PMID: 31150685]
[44]
Roghani M, Jalali-Nadoushan MR, Baluchnejadmojarad T, et al. Endothelium-dependent effect of sesame seed feeding on vascular reactivity of streptozotocin-diabetic rats: Underlying mechanisms. Iran J Pharm Res 2013; 12(3): 377-85.
[PMID: 24250645]
[PMID: 24250645]
[45]
Takeuchi H, Mooi LY, Inagaki Y, He P. Hypoglycemic effect of a hot-water extract from defatted sesame (Sesamum indicum L.) seed on the blood glucose level in genetically diabetic KK-Ay mice. Biosci Biotechnol Biochem 2001; 65(10): 2318-21.
[http://dx.doi.org/10.1271/bbb.65.2318] [PMID: 11758931]
[http://dx.doi.org/10.1271/bbb.65.2318] [PMID: 11758931]
[46]
Ahmad S, ElSherbiny NM, Jamal MS, et al. Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy. J Neuroimmunol 2016; 295-296: 47-53.
[http://dx.doi.org/10.1016/j.jneuroim.2016.04.002] [PMID: 27235348]
[http://dx.doi.org/10.1016/j.jneuroim.2016.04.002] [PMID: 27235348]
[47]
Hong L, Yi W, Liangliang C, Juncheng H, Qin W, Xiaoxiang Z. Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice. J Sci Food Agric 2013; 93(8): 1833-8.
[http://dx.doi.org/10.1002/jsfa.5974] [PMID: 23239503]
[http://dx.doi.org/10.1002/jsfa.5974] [PMID: 23239503]
[48]
Thuy TD, Phan NN, Wang CY, et al. Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Mol Med Rep 2017; 15(5): 2949-56.
[http://dx.doi.org/10.3892/mmr.2017.6420] [PMID: 28358428]
[http://dx.doi.org/10.3892/mmr.2017.6420] [PMID: 28358428]
[49]
Cebova M, Rehakova R, Kosutova M, Pechanova O. Simvastatin does not affect nitric oxide generation increased by sesame oil in obese Zucker rats. Oxid Med Cell Longev 2018; 20185413423
[http://dx.doi.org/10.1155/2018/5413423] [PMID: 30245774]
[http://dx.doi.org/10.1155/2018/5413423] [PMID: 30245774]
[50]
Bigoniya P, Nishad R, Singh CS. Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced type 2 diabetes in rats. Food Chem 2012; 133(4): 1355-61.
[http://dx.doi.org/10.1016/j.foodchem.2012.01.112]
[http://dx.doi.org/10.1016/j.foodchem.2012.01.112]
[51]
Sharma AK, Bharti S, Bhatia J, et al. Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS. J Nutr Biochem 2012; 23(11): 1482-9.
[http://dx.doi.org/10.1016/j.jnutbio.2011.09.011] [PMID: 22398194]
[http://dx.doi.org/10.1016/j.jnutbio.2011.09.011] [PMID: 22398194]
[52]
Bhuvaneswari P, Krishnakumari S. Antihyperglycemic potential of Sesamum indicum (Linn) seeds in streptozotocin induced diabetic rats. Int J Pharm Pharm Sci 2012; 4(1): 527-31.
[53]
Bhuvaneswari P, Krishnakumari S. Nephroprotective effects of ethanolic extract of Sesamum indicum seeds (Linn.) in streptozotocin induced diabetic male albino rats. Int J Green Pharm 2012; 6(4): 330-5.
[http://dx.doi.org/10.4103/0973-8258.108249]
[http://dx.doi.org/10.4103/0973-8258.108249]
[54]
Anitha U, Karuppasamy R. Sesame meal administration attenuate the high-fat diet induced lipid abnormalities and improve insulin sensitivity in wistar rats. Int J Pharm Bio Sci 2011; 2(4): 499-505.
[55]
Roghani M, Baluchnejadmojarad T, Roghani Dehkord F. The sesame lignan sesamin attenuates vascular permeability in rats with streptozotocin-induced diabetes: Involvement of oxidative stress. Int J Endocrinol Metab 2011; 9(1): 248-52.
[http://dx.doi.org/10.5812/kowsar.1726913X.2142]
[http://dx.doi.org/10.5812/kowsar.1726913X.2142]
[56]
ElTahir KEH, Al-Tahir AY, Ageel AM. Pharmacological studies on sesame and Nigella sativa fixed oil: Effects on the sensitivities of the adrenoceptors, baroreceprors, platelets and the uterus of the rat. Saudi Pharm J 1999; 7(4): 205-15.
[57]
Ahmad HS. AL-Janabi QAR, AL-Qesee RKS. Study of the therapeutic role against diabetes for olive oil, soybean oil and sesame oil on some standards of male reproductive system of local rabbits. Indian J Public Health Res Dev 2020; 11(4): 1290-6.
[58]
Takada S, Kinugawa S, Matsushima S, et al. Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. Exp Physiol 2015; 100(11): 1319-30.
[http://dx.doi.org/10.1113/EP085251] [PMID: 26300535]
[http://dx.doi.org/10.1113/EP085251] [PMID: 26300535]
[59]
Yargholi A, Najafi MH, Zareian MA, Hawkins J, Shirbeigi L, Ayati MH. The effects of sesame consumption on glycemic control in adults: A systematic review and meta-analysis of randomized clinical trial. Evid Based Complement Alternat Med 2021; 20212873534
[http://dx.doi.org/10.1155/2021/2873534] [PMID: 34707665]
[http://dx.doi.org/10.1155/2021/2873534] [PMID: 34707665]
[60]
Mahmoodi MR, Kimiagar M, Mehrabi Y. The effects of omega-3 plus vitamin E and zinc plus vitamin C supplementation on cardiovascular risk markers in postmenopausal women with type 2 diabetes. Ther Adv Endocrinol Metab 2014; 5(4): 67-76.
[http://dx.doi.org/10.1177/2042018814548028] [PMID: 25343022]
[http://dx.doi.org/10.1177/2042018814548028] [PMID: 25343022]
[61]
Mahmoodi MR, Mohammadizadeh M. Therapeutic potentials of Nigella sativa preparations and its constituents in the management of diabetes and its complications in experimental animals and patients with diabetes mellitus: A systematic review. Complement Ther Med 2020; 50102391
[http://dx.doi.org/10.1016/j.ctim.2020.102391] [PMID: 32444053]
[http://dx.doi.org/10.1016/j.ctim.2020.102391] [PMID: 32444053]
[62]
Mahmoodi MR, Mashayekh M, Entezari MH. Fortification of wheat bread with 3-7% defatted soy flour improves formulation, organoleptic characteristics, and rat growth rate. Int J Prev Med 2014; 5(1): 37-45.
[PMID: 24554990]
[PMID: 24554990]
[63]
Wikul A, Damsud T, Kataoka K, Phuwapraisirisan P. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorg Med Chem Lett 2012; 22(16): 5215-7.
[http://dx.doi.org/10.1016/j.bmcl.2012.06.068] [PMID: 22818971]
[http://dx.doi.org/10.1016/j.bmcl.2012.06.068] [PMID: 22818971]
[64]
Hilmi Y, Abushama MF, Abdalgadir H, Khalid A, Khalid H. A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential. BMC Complement Altern Med 2014; 14(1): 149-53.
[http://dx.doi.org/10.1186/1472-6882-14-149] [PMID: 24885334]
[http://dx.doi.org/10.1186/1472-6882-14-149] [PMID: 24885334]
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