Biological Importance and Pharmacological Activities of Meranzin and
Meranzin Hydrate Against Human Disorders

Dinesh   Kumar   Patel; Kanika      Patel

doi:10.2174/2666001602666220524140540

Abstract

Background: Herbal plant-based products and their derived phytochemicals have been used in the complementary and alternative systems of medicine for the treatment of human disorders. Vegetables, fruits, seeds, nuts, coffee, tea, and wine contain significant amounts of coumarin class phytochemicals. Coumarin is found to be present in cassia leaf oil, cinnamon bark oil, lavender oil, and microorganism-derived drugs.

Methods: Scientific databases, such as Google Scholar, Science Direct, Scopus, and PubMed, have been searched to collect the scientific information regarding meranzin and meranzin hydrate in the present work in order to know their medicinal importance and pharmacological activities in the medicine. Pharmacological activity data of meranzin and meranzin hydrates has been thoroughly studied from scientific databases and analyzed in the present work to evaluate their biological potential against human disorders. Analytical data on meranzin and meranzin hydrates have been also collected and analyzed in the present work to know the importance of analytical techniques for the standardization of plant material.

Results: Scientific data analysis revealed the biological potential of meranzin and meranzin hydrates against human health complications. Meranzin was found to be present in the Fructus aurantii, Triphasia trifolia, Cnidium monnieri, and Murraya exotica. Scientific data analysis revealed the biological potential of meranzin and meranzin hydrates in the medicine due to their anti-depressant, anti-fibrotic, anti-proliferative, anti-atherosclerosis, and anti-bacterial activities. Further scientific data analysis revealed the biological effectiveness of meranzin and meranzin hydrates on neuroinflammation, intestinal motility, and various forms of enzymes. Furthermore, pharmacokinetic parameters for meranzin and meranzin hydrates were also investigated in the present work. Chromatography techniques used for the analysis were also summarized and discussed to examine the importance of isolation, separation, and quantification of meranzin and meranzin hydrates.

Conclusion: Present study will facilitate scientists in the development of effective medicine from meranzin and meranzin hydrates against the various human health complications.

Keywords: Meranzin, coumarin, meranzin hydrate, antifibrotic, antiproliferative, antiatherosclerosis, antibacterial.

Graphical Abstract

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Biological Importance and Pharmacological Activities of Meranzin and Meranzin Hydrate Against Human Disorders

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