Login Register Cart 0
Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Renal Artery Resistive Index and Estimated Glomerular Filtration Rate in Patients with Non-alcoholic Fatty Liver Disease

Author(s): Yusuf Aksu*, Ali Ugur Uslu, Gulten Tarhan and Şaban Tiryaki

Volume 18, Issue 12, 2022

Published on: 06 July, 2022

Article ID: e160522204841 Pages: 7

DOI: 10.2174/1573405618666220516123519

Price: $65

Abstract

Objective: Non-alcoholic fatty liver disease (NAFLD) may affect many organs and systems, especially the kidney as well as the liver. While NAFLD’s renal impacts can be evaluated via the estimated glomerular filtration rate (eGFR), its effects on renal hemodynamic changes can be monitored with the renal resistive index (RRI). Our aim in this study is to evaluate RRI and eGFR in NAFLD patients.

Materials and Methods: In this study, a total of 69 patients with NAFLD and 50 age- and gendermatched healthy controls were included. The basic clinical and laboratory parameters of patient and control groups were assessed and recorded.

Results: In the patient group, the RRI was observed as 0.64±0.06 and eGFR value as 86±52 (mL/min/1.73m2), while in the control group, the RRI was 0.61±0.05 and eGFR was 95.40±20.21 (mL/min/1.73m2). Compared to the control group, the RRI and eGFR values were significantly different in the patient group (PRRI=0.003 and PeGFR=0.025). There was a negative correlation observed between the RRI and eGFR (r=-0.347, P=0.003). Receiver-operating characteristic curve analysis suggested that the optimum RRI cut-off value for patients with NAFLD is 0.62, with 65% sensitivity and 60% specificity (p=0.002). There was an independent relationship found between the RRI and eGFR according to the linear regression analysis (β=-0.301, P=0.015).

Conclusion: This study shows that RRI may be an indicator of renal functions, such as eGFR in patients with NAFLD.

Keywords: Non-alcoholic fatty liver disease, kidney, renal artery resistive index, estimated glomerular filtration rate, liver, kidney.

Graphical Abstract

[1]
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016; 64(1): 73-84.
[http://dx.doi.org/10.1002/hep.28431] [PMID: 26707365]
[2]
Byrne CD, Targher G. NAFLD as a driver of chronic kidney disease. J Hepatol 2020; 72(4): 785-801.
[http://dx.doi.org/10.1016/j.jhep.2020.01.013] [PMID: 32059982]
[3]
Khan RS, Bril F, Cusi K, Newsome PN. Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease. Hepatology 2019; 70(2): 711-24.
[http://dx.doi.org/10.1002/hep.30429] [PMID: 30556145]
[4]
Mikolasevic I, Milic S, Turk Wensveen T, et al. Nonalcoholic fatty liver disease - A multisystem disease? World J Gastroenterol 2016; 22(43): 9488-505.
[http://dx.doi.org/10.3748/wjg.v22.i43.9488] [PMID: 27920470]
[5]
Adams LA, Anstee QM, Tilg H, Targher G. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut 2017; 66(6): 1138-53.
[http://dx.doi.org/10.1136/gutjnl-2017-313884] [PMID: 28314735]
[6]
Porrini E, Ruggenenti P, Luis-Lima S, et al. Estimated GFR: Time for a critical appraisal. Nat Rev Nephrol 2019; 15(3): 177-90.
[http://dx.doi.org/10.1038/s41581-018-0080-9] [PMID: 30518813]
[7]
Drudi FM, Cantisani V, Granata A, et al. Multiparametric ultrasound in the evaluation of kidney disease in elderly. J Ultrasound 2020; 23(2): 115-26.
[http://dx.doi.org/10.1007/s40477-019-00390-5] [PMID: 31197634]
[8]
Boddi M. Renal Ultrasound (and Doppler Sonography) in Hypertension: An Update. Adv Exp Med Biol 2017; 956: 191-208.
[http://dx.doi.org/10.1007/5584_2016_170] [PMID: 27966109]
[9]
Lebecque O, Dupont M. Puumala hantavirus: An imaging review. Acta Radiol 2020; 61(8): 1072-9.
[http://dx.doi.org/10.1177/0284185119889564] [PMID: 31805769]
[10]
Sener TE, Tanidir Y, Bin Hamri S, et al. Effects of flexible ureteroscopy on renal blood flow: A prospective evaluation. Scand J Urol 2018; 52(3): 213-8.
[http://dx.doi.org/10.1080/21681805.2018.1437770] [PMID: 29463207]
[11]
Heneghan RE, Starnes BW, Nathan DP, Zierler RE. Renal duplex ultrasound findings in fenestrated endovascular aortic repair for juxtarenal aortic aneurysms. J Vasc Surg 2016; 63(4): 915-21.
[http://dx.doi.org/10.1016/j.jvs.2015.10.090] [PMID: 26749477]
[12]
Tokushige K, Ikejima K, Ono M, et al. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020. J Gastroenterol 2021; 56(11): 951-63.
[http://dx.doi.org/10.1007/s00535-021-01796-x] [PMID: 34533632]
[13]
Slieker RC, van der Heijden AAWA, Siddiqui MK, et al. Performance of prediction models for nephropathy in people with type 2 diabetes: Systematic review and external validation study. BMJ 2021; 374(2134): n2134.
[http://dx.doi.org/10.1136/bmj.n2134] [PMID: 34583929]
[14]
Cannon RM, Davis EG, Jones CM. A tale of two kidneys: Differences in graft survival for kidneys allocated to simultaneous liver kidney transplant compared with contralateral kidney from the same donor. J Am Coll Surg 2019; 229(1): 7-17.
[http://dx.doi.org/10.1016/j.jamcollsurg.2019.04.019] [PMID: 31034884]
[15]
Targher G, Byrne CD. Non-alcoholic fatty liver disease: An emerging driving force in chronic kidney disease. Nat Rev Nephrol 2017; 13(5): 297-310.
[http://dx.doi.org/10.1038/nrneph.2017.16] [PMID: 28218263]
[16]
Chen PC, Kao WY, Cheng YL, et al. The correlation between fatty liver disease and chronic kidney disease. J Formos Med Assoc 2020; 119(1 Pt 1): 42-50.
[http://dx.doi.org/10.1016/j.jfma.2019.02.010] [PMID: 30876789]
[17]
Hsieh MH, Wu KT, Chen YY, et al. Higher NAFLD fibrosis score is associated with impaired eGFR. J Formos Med Assoc 2020; 119(1 Pt 3): 496-503.
[http://dx.doi.org/10.1016/j.jfma.2019.07.007] [PMID: 31353118]
[18]
Jang HR, Kang D, Sinn DH, et al. Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: A cohort study. Sci Rep 2018; 8(1): 4718.
[http://dx.doi.org/10.1038/s41598-018-23014-0] [PMID: 29549269]
[19]
Khandelwal R, Dassanayake AS, Conjeevaram HS, Singh SP. Non-alcoholic fatty liver disease in diabetes: When to refer to the hepatologist? World J Diabetes 2021; 12(9): 1479-93.
[http://dx.doi.org/10.4239/wjd.v12.i9.1479] [PMID: 34630901]
[20]
Afsar B, Elsurer R, Sezer S, Ozdemir FN. Insulin resistance is associated with increased renal resistive index independent of other factors in newly diagnosed type 2 diabetes mellitus and hypertensive patients. Metabolism 2010; 59(2): 279-84.
[http://dx.doi.org/10.1016/j.metabol.2009.07.025] [PMID: 19793596]
[21]
Trovato GM, Pace P, Martines GF, Trovato FM, Pirri C, Catalano D. Stress, abdominal obesity and intrarenal resistive index in essential hypertension. Clin Ter 2012; 163(4): 299-305.
[PMID: 23007813]
[22]
Bruno RM, Daghini E, Landini L, et al. Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes. Diabetologia 2011; 54(9): 2430-9.
[http://dx.doi.org/10.1007/s00125-011-2148-y] [PMID: 21499674]
[23]
Afsar B, Elsurer R. Comparison of renal resistive index among patients with Type 2 diabetes with different levels of creatinine clearance and urinary albumin excretion. Diabet Med 2012; 29(8): 1043-6.
[http://dx.doi.org/10.1111/j.1464-5491.2012.03593.x] [PMID: 22269249]
[24]
Kiapidou S, Liava C, Kalogirou M, Akriviadis E, Sinakos E. Chronic kidney disease in patients with non-alcoholic fatty liver disease: What the Hepatologist should know? Ann Hepatol 2020; 19(2): 134-44.
[http://dx.doi.org/10.1016/j.aohep.2019.07.013] [PMID: 31606352]
[25]
Wu Y, Chen Z, Fuda H, et al. Oxidative stress linked organ lipid hydroperoxidation and dysregulation in mouse model of nonalcoholic steatohepatitis: Revealed by lipidomic profiling of liver and kidney. Antioxidants 2021; 10(10): 1602.
[http://dx.doi.org/10.3390/antiox10101602] [PMID: 34679736]
[26]
Shen Z, Munker S, Luo F, Ma H, Yu C, Li Y. Effect of non-alcoholic fatty liver disease on estimated glomerular filtration rate could be dependent on age. PLoS One 2015; 10(6): e0130614.
[http://dx.doi.org/10.1371/journal.pone.0130614] [PMID: 26087253]
[27]
Catalano D, Trovato GM, Martines GF, Pirri C, Trovato FM. Renal function and severity of bright liver. Relationship with insulin resistance, intrarenal resistive index, and glomerular filtration rate. Hepatol Int 2011; 5(3): 822-9.
[http://dx.doi.org/10.1007/s12072-011-9254-2] [PMID: 21484130]

Rights & Permissions Print Cite
Article Metrics
13
© 2024 Bentham Science Publishers | Privacy Policy