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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Research Article

Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide

Author(s): Dan Chen, Shuangyan Yang*, Jie Ding and Ailing Liu

Volume 23, Issue 5, 2023

Published on: 27 July, 2022

Page: [425 - 432] Pages: 8

DOI: 10.2174/1566524022666220513111637

Price: $65

Abstract

Background: Preeclampsia is a disorder of hypertension and proteinuria accompanied by abnormal inflammatory responses. Both aspirin and quercetin possess anti-inflammatory and anti-hypertensive properties. A low dose of aspirin is recommended for the prevention of preeclampsia in patients with preeclampsia history. Whether quercetin can enhance the effect of aspirin on preeclampsia remains elusive.

Methods: Female Sprague-Dawley pregnant rats were treated with daily administration of aspirin, quercetin, or a combination of aspirin and quercetin and subsequently received lipopolysaccharides (LPS) injection to induce preeclampsia-like symptoms. The systolic blood pressure and proteinuria from all groups of rats were assessed.

Results: Our results demonstrated that the combination of quercetin and aspirin exerted significantly stronger effects than aspirin alone on decreasing systolic blood pressure and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type decidual macrophages polarization in an LPS-induced rat model of preeclampsia.

Conclusion: This study suggested that quercetin may serve as an excellent supplement to aspirin in preventing or treating patients with preeclampsia.

Keywords: Preeclampsia, aspirin, quercetin, lipopolysaccharides, macrophages, pathogenesis.

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