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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Systematic Review Article

Effectiveness of Photobiomodulation Therapy on Neuropathic Pain, Nerve Conduction and Plantar Pressure Distribution in Diabetic Peripheral Neuropathy - A Systematic Review

Author(s): Hrishikesh Yadav Korada, Esha Arora, Gundmi Arun Maiya*, Sharath Rao, Manjunath Hande, Sahana Shetty, Shubha Gundmi, Parameshwar Anche and Sampath Amravadi

Volume 19, Issue 9, 2023

Published on: 13 September, 2022

Article ID: e290422204244 Pages: 9

DOI: 10.2174/1573399818666220429085256

Price: $65

Abstract

Background: Diabetic peripheral neuropathy is a severe complication of type 2 diabetes mellitus. The most common symptoms are neuropathic pain and altered sensorium due to damage to small nerve fibers. Altered plantar pressure distribution is also a major risk factor in diabetic peripheral neuropathy, leading to diabetic foot ulcers.

Objective: The objective of this systematic review was to analyze the various studies involving photobiomodulation therapy on neuropathic pain and plantar pressure distribution in diabetic peripheral neuropathy.

Methods: We conducted a systematic review (PubMed, Web of Science, CINAHL, and Cochrane) to summarise the evidence on photobiomodulation therapy for Diabetic Peripheral Neuropathy with type 2 diabetes mellitus. Randomized and non-randomized studies were included in the review.

Results: This systematic review included eight studies in which photobiomodulation therapy showed improvement in neuropathic pain and nerve conduction velocity. It also reduces plantar pressure distribution, which is a high risk for developing foot ulcers.

Conclusion: We conclude that photobiomodulation therapy is an effective, non-invasive, and costefficient means to improve neuropathic pain and altered plantar pressure distribution in diabetic peripheral neuropathy.

Keywords: Systematic review, low level laser therapy, plantar pressure distribution, neuropathic pain, ulcers, quality of life.

[1]
Saeedi P, Petersohn I, Salpea P, et al. IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2019; 157: 107843.
[http://dx.doi.org/10.1016/j.diabres.2019.107843] [PMID: 31518657]
[2]
Jung J, Kim MG, Kang YJ, Min K, Han KA, Choi H. Vibration perception threshold and related factors for balance assessment in patients with type 2 diabetes mellitus. Int J Environ Res Public Health 2021; 18(11): 6046.
[http://dx.doi.org/10.3390/ijerph18116046] [PMID: 34199765]
[3]
Boulton AJ, Armstrong DG, Kirsner RS, et al. Diagnosis and management of diabetic foot complications. Nat Lib Med 2018.
[http://dx.doi.org/10.2337/db20182-1]
[4]
Manu C, Lacopi E, Bouillet B, et al. Delayed referral of patients with diabetic foot ulcers across Europe: Patterns between primary care and specialised units. J Wound Care 2018; 27(3): 186-92.
[http://dx.doi.org/10.12968/jowc.2018.27.3.186] [PMID: 29509115]
[5]
Kaya Z, Karaca A. Evaluation of nurses’ knowledge levels of diabetic foot care management. Nurs Res Pract 2018; 2018: 8549567.
[http://dx.doi.org/10.1155/2018/8549567] [PMID: 30057810]
[6]
Guell C, Unwin N. Barriers to diabetic foot care in a developing country with a high incidence of diabetes related amputations: An exploratory qualitative interview study. BMC Health Serv Res 2015; 15(1): 377.
[http://dx.doi.org/10.1186/s12913-015-1043-5] [PMID: 26369788]
[7]
Schaper NC, van Netten JJ, Apelqvist J, Bus SA, Hinchliffe RJ, Lipsky BA. IWGDF Editorial Board. Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev 2020; 36(S1) (Suppl. 1): e3266.
[http://dx.doi.org/10.1002/dmrr.3266] [PMID: 32176447]
[8]
Maiya AG, Gundmi S, Matpady P, et al. Prevalence of foot complications in people with type 2 diabetes mellitus: A community-based survey in rural Udupi. Int J Low Extrem Wounds 2018; 17(3): 169-75.
[http://dx.doi.org/10.1177/1534734618791853] [PMID: 30111220]
[9]
Yovera-Aldana M, Velásquez-Rimachi V, Huerta-Rosario A, et al. Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis. PLoS One 2021; 16(5): e0251642.
[http://dx.doi.org/10.1371/journal.pone.0251642] [PMID: 33984049]
[10]
Lavery LA, Wunderlich RP, Tredwell JL. Disease management for the diabetic foot: Effectiveness of a diabetic foot prevention program to reduce amputations and hospitalizations. Diabetes Res Clin Pract 2005; 70(1): 31-7.
[http://dx.doi.org/10.1016/j.diabres.2005.02.010] [PMID: 16126121]
[11]
Hamed E, Monem MA. A review of diabetic peripheral neuropathy management given recent guidelines updates. Arch Gen Intern Med 2018; 2(4): 1-5.
[http://dx.doi.org/10.4066/2591-7951.1000060]
[12]
Cg SK, Maiya AG, Hande HM, Vidyasagar S, Rao K, Rajagopal KV. Efficacy of low level laser therapy on painful diabetic peripheral neuropathy. Laser Ther 2015; 24(3): 195-200.
[http://dx.doi.org/10.5978/islsm.15-OR-12] [PMID: 26557734]
[13]
M A. Ummer V S, Maiya AG, Hande M. Low level laser therapy for the patients with painful diabetic peripheral neuropathy - A systematic review. Diabetes Metab Syndr 2019; 13(4): 2667-70.
[http://dx.doi.org/10.1016/j.dsx.2019.07.035] [PMID: 31405692]
[14]
Kazemi-Khoo N. Successful treatment of diabetic foot ulcers with low-level laser therapy. Foot 2006; 16(4): 184-7.
[http://dx.doi.org/10.1016/j.foot.2006.05.004]
[15]
Schindl A, Heinze G, Schindl M, Pernerstorfer-Schön H, Schindl L. Systemic effects of low-intensity laser irradiation on skin microcirculation in patients with diabetic microangiopathy. Microvasc Res 2002; 64(2): 240-6.
[http://dx.doi.org/10.1006/mvre.2002.2429] [PMID: 12204648]
[16]
Mohamed RA, Abdallah GA, Abdeen HA, Nassif AA. Influence of low level laser therapy versus pulsed electromagnetic field on diabetic peripheral neuropathy. Phys Ther Rehabil 2017; 4: 17.
[http://dx.doi.org/10.7243/2055-2386-4-17]
[17]
Moher D, Shamseer L, Clarke M, et al. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4(1): 1-9.
[http://dx.doi.org/10.1186/2046-4053-4-1] [PMID: 25554246]
[18]
Checklist for text and opinion critical appraisal checklist for text and opinion 2. 2017. Available from: jbi.global/sites/default/files/2019-05/JBI_Critical_Appraisal- Checklist_for_Text_and_Opinion2017_0.pdf
[19]
Begum MR. Validity and reliability of visual analogue scale (vas) for pain measurement. J Med Case Rep Rev 2019; 2(11)
[20]
Shanb AA, Youssef EF, Al Baker WI, Al-Khamis FA, Hassan A, Jatoi NA. The efficacy of adding electromagnetic therapy or laser therapy to medications in patients with diabetic peripheral neuropathy. J Lasers Med Sci 2020; 11(1): 20-8.
[http://dx.doi.org/10.15171/jlms.2020.05] [PMID: 32099623]
[21]
Yamany AA, Sayed HM. Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy. J Adv Res 2012; 3(1): 21-8.
[http://dx.doi.org/10.1016/j.jare.2011.02.009]
[22]
Bashiri H. Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta Med Iran 2013; 51(8): 543-7.
[PMID: 24026991]
[23]
Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V. Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: A controlled trial. Diabetes Care 2004; 27(4): 921-4.
[http://dx.doi.org/10.2337/diacare.27.4.921] [PMID: 15047649]
[24]
Walker J. Relief from chronic pain by low power laser irradiation. Neurosci Lett 1983; 43(2-3): 339-44.
[http://dx.doi.org/10.1016/0304-3940(83)90211-2] [PMID: 6200808]
[25]
Khamseh ME, Kazemikho N, Aghili R, et al. Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy. Lasers Med Sci 2011; 26(6): 831-5.
[http://dx.doi.org/10.1007/s10103-011-0977-z] [PMID: 21853320]
[26]
Yamany AA, Bitesha K. Effect of 850 nm He-Ne laser therapy on nerve conduction and foot planter pressures distribution of painful diabetic neuropathy: A randomized controlled trial. J Nov Physiother 2016; 6(4): 300.
[27]
da Silva Oliveira VR, Santos-Eichler RA, Dale CS. Photobiomodulation increases cell viability via AKT activation in an in vitro model of diabetes induced by glucose neurotoxicity. Lasers Med Sci 2020; 35(1): 149-56.
[http://dx.doi.org/10.1007/s10103-019-02808-2] [PMID: 31222481]
[28]
Jere SW, Houreld NN, Abrahamse H. Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing. Cytokine Growth Factor Rev 2019; 50: 52-9.
[http://dx.doi.org/10.1016/j.cytogfr.2019.03.001] [PMID: 30890300]
[29]
Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G. Low-level laser therapy facilitates superficial wound healing in humans: A triple-blind, sham-controlled study. J Athl Train 2004; 39(3): 223-9.
[PMID: 15496990]
[30]
Oron A, Oron U, Streeter J, et al. Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 2007; 24(4): 651-6.
[http://dx.doi.org/10.1089/neu.2006.0198] [PMID: 17439348]
[31]
Funk JO, Kruse A, Kirchner H. Cytokine production after helium-neon laser irradiation in cultures of human peripheral blood mononuclear cells. J Photochem Photobiol B 1992; 16(3-4): 347-55.
[http://dx.doi.org/10.1016/1011-1344(92)80022-N] [PMID: 1479476]
[32]
O’Connor AB, Dworkin RH. Treatment of neuropathic pain: An overview of recent guidelines. Am J Med 2009; 122(10) (Suppl.): S22-32.
[http://dx.doi.org/10.1016/j.amjmed.2009.04.007] [PMID: 19801049]
[33]
Sutkowska E, Sutkowski K. Sokołowski M, Franek E, Dragan S Sr. Distribution of the highest plantar pressure regions in patients with diabetes and its association with peripheral neuropathy, gender, age, and BMI: One centre study. J Diabetes Res 2019; 2019: 7395769.
[http://dx.doi.org/10.1155/2019/7395769] [PMID: 31380446]
[34]
Góralczyk K. Szymańska J, Łukowicz M, et al. Effect of LLLT on endothelial cells culture. Lasers Med Sci 2015; 30(1): 273-8.
[http://dx.doi.org/10.1007/s10103-014-1650-0] [PMID: 25231826]
[35]
Gore M, Brandenburg NA, Dukes E, Hoffman DL, Tai KS, Stacey B. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage 2005; 30(4): 374-85.
[http://dx.doi.org/10.1016/j.jpainsymman.2005.04.009] [PMID: 16256902]
[36]
Kalinina OV, Alekseeva NV, Burtsev EM. Infrared laser therapy in distal diabetic polyneuropathy. Zh Nevrol Psikhiatr Im S S Korsakova 1998; 98(6): 23-5.
[PMID: 9677693]
[37]
Vinik AI, Mehrabyan A. Diabetic neuropathies. Med Clin North Am 2004; 88(4): 947-999, xi.
[http://dx.doi.org/10.1016/j.mcna.2004.04.009] [PMID: 15308387]
[38]
Höhne A, Stark C, Brüggemann GP. Plantar pressure distribution in gait is not affected by targeted reduced plantar cutaneous sensation. Clin Biomech (Bristol, Avon) 2009; 24(3): 308-13.
[http://dx.doi.org/10.1016/j.clinbiomech.2009.01.001] [PMID: 19201070]
[39]
Mohd Said A, Justine M, Manaf H. Plantar pressure distribution among older persons with different types of foot and its correlation with functional reach distance. Scientifica (Cairo) 2016; 2016: 8564020.
[http://dx.doi.org/10.1155/2016/8564020] [PMID: 27980874]

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