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Research Article

微RNA在急慢性心力衰竭中的差异表达

卷 29, 期 30, 2022

发表于: 08 June, 2022

页: [5130 - 5138] 页: 9

弟呕挨: 10.2174/0929867329666220426095655

价格: $65

摘要

背景：MicroRNA在转录后水平上修饰蛋白质表达，其循环水平可能有助于识别潜在的分子途径。 目的：评估慢性和急性心力衰竭（HF）中与心肌细胞能量底物、自噬和缺血相关的microRNA的差异表达。 方法：在这项病例对照研究中，我们研究了19例急性HF（AHF）患者和19例慢性HF（CHF）患者。在患者抵达时，48小时和120小时从患者那里收集基本人口统计学和临床特征。在所有研究点收集用于microRNA测量（miR-22，-92a和-499），B型利钠肽（BNP），C反应蛋白和高灵敏度心脏肌钙蛋白I的血液样品。在这项研究中，我们纳入了左心室射血分数为<40%的受试者。 结果：基线时，与充血性心力衰竭相比，AHF的循环miR-22水平高出1.9倍（p<0.001），miR-92a水平高出1.25倍（p=0.003），miR-499水平低5倍（p<0.001）。有趣的是，发现循环miR-499与BNP水平相关（r = 0.47，p = 0.01）。在随访时，所有三种检查的微RNA（miR-22，p = 0.001，miR-92a，p = 0.001和miR-499，p<0.001）的水平逐步增加，但对于CHF受试者则没有 结论：MicroRNA -22、-92a和-499在慢性和急性HF受试者中差异表达。MicroRNA特征也被差异化地表达到患者的出院。这些发现可能对慢性和急性心力衰竭患者的诊断、进展和治疗具有重要意义。

关键词: 急性心力衰竭，miRNA，B型利钠肽，生物标志物，差异表达，慢性心力衰竭。

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