Abstract
Background: Polyphenols are a group of secondary plant metabolites produced in plants as a protective system against oxidative stress, UV radiation, pathogens, and predatorial attacks. Flavonoids are a major class of plant phenolics present in fruits, vegetables, tea, and red wine. Tectoridin, also called 40,5,7-thrihydroxy-6-methoxyisoflavone-7-Ob-D-glucopyranoside is an isoflavone glycoside present in the flower of Porites lobata.
Methods: Present work focused on the biological importance, therapeutic potential, and pharmacological activities of tectoridin in medicine. Numerous scientific data have been collected from different literature databases such as Google Scholar, Science Direct, PubMed, and Scopus to know the health beneficial potential of tectoridin. Pharmacological data have been analyzed in the present work to know the biological effectiveness of tectoridin against human disorders. Analytical data of tectoridin have been collected and analyzed in the present work to know the importance of modern analytical methods in the isolation, separation, and identification of tectoridin.
Results: Scientific data analysis revealed the biological importance and therapeutic benefit of tectoridin in medicine, signifying the therapeutic potential in healthcare systems. The biological activities of tectoridin are mainly due to its anti-inflammatory, anti-platelet, anti-angiogenic, hepatoprotective, anti-tumor, estrogenic, antioxidant, and hypoglycemic activity. However, this work has also presented the effectiveness of tectoridin against rat lens aldose reductase, nitric oxide, skeletal and cardiac muscle sarcoplasmic reticulum, and enzymes. Analytical data signified the importance of modern analytical techniques for separation, identification, and isolation of tectoridin.
Conclusion: The present work signified the biological importance and therapeutic benefit of tectoridin in medicine and other allied health sectors.
Keywords: Tectoridin, anti-inflammatory, hepatoprotective, anti-angiogenic, anti-tumor, estrogenic, hypoglycemic, antiplatelet, antioxidant activity.
Graphical Abstract
[1]
Silva F de O, Miranda TG, Justo T, et al. Soybean meal and fermented soybean meal as functional ingredients for the production of low-carb, high-protein, high-fiber and high isoflavones biscuits. Lebensm Wiss Technol 2018; 90: 224-31.
[http://dx.doi.org/10.1016/j.lwt.2017.12.035]
[http://dx.doi.org/10.1016/j.lwt.2017.12.035]
[2]
Khosravi A, Razavi SH. Therapeutic effects of polyphenols in fermented soybean and black soybean products. J Funct Foods 2021; 81104467
[http://dx.doi.org/10.1016/j.jff.2021.104467]
[http://dx.doi.org/10.1016/j.jff.2021.104467]
[3]
Day AJ, Cañada FJ, Díaz JC, et al. Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 2000; 468(2-3): 166-70.
[http://dx.doi.org/10.1016/S0014-5793(00)01211-4] [PMID: 10692580]
[http://dx.doi.org/10.1016/S0014-5793(00)01211-4] [PMID: 10692580]
[4]
Yatsu FKJ, Koester LS, Bassani VL. Isoflavone-aglycone fraction from Glycine max: A promising raw material for isoflavone-based pharmaceutical or nutraceutical products. Rev Bras Farmacogn 2016; 26(2): 259-67.
[http://dx.doi.org/10.1016/j.bjp.2015.12.004]
[http://dx.doi.org/10.1016/j.bjp.2015.12.004]
[5]
Kumar G, Saad KR, Arya M, et al. The Synergistic role of serotonin and melatonin during temperature stress in promoting cell division, ethylene and isoflavones biosynthesis in Glycine max. Curr Plant Biol 2021; 26100206
[http://dx.doi.org/10.1016/j.cpb.2021.100206]
[http://dx.doi.org/10.1016/j.cpb.2021.100206]
[6]
Reed KE, Camargo J, Hamilton-Reeves J, Kurzer M, Messina M. Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies. Reprod Toxicol 2021; 100: 60-7.
[http://dx.doi.org/10.1016/j.reprotox.2020.12.019] [PMID: 33383165]
[http://dx.doi.org/10.1016/j.reprotox.2020.12.019] [PMID: 33383165]
[7]
de Melo EL, Pinto AM, Baima CLB, et al. Evaluation of the in vitro release of isoflavones from soybean germ associated with kefir culture in the gastrointestinal tract and anxiolytic and antidepressant actions in zebrafish (Danio rerio). J Funct Foods 2020; 70103986
[http://dx.doi.org/10.1016/j.jff.2020.103986]
[http://dx.doi.org/10.1016/j.jff.2020.103986]
[8]
Zhang R, Piao MJ, Oh MC, et al. Protective effect of an isoflavone, tectorigenin, against oxidative stress-induced cell death via catalase activation. J Cancer Prev 2016; 21(4): 257-63.
[http://dx.doi.org/10.15430/JCP.2016.21.4.257] [PMID: 28053960]
[http://dx.doi.org/10.15430/JCP.2016.21.4.257] [PMID: 28053960]
[9]
Kamiya T, Takano A, Kido Y, et al. Evaluation of the estrogenic activity of Pueraria (Kudzu) flower extract and its major isoflavones using ER-binding and uterotrophic bioassays. Pharmacol Pharm 2013; 04(2): 255-60.
[http://dx.doi.org/10.4236/pp.2013.42036]
[http://dx.doi.org/10.4236/pp.2013.42036]
[10]
Lu K-H, Liu C-T, Raghu R, Sheen L-Y. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease. J Tradit Complement Med 2012; 2(2): 115-22.
[http://dx.doi.org/10.1016/S2225-4110(16)30084-0] [PMID: 24716123]
[http://dx.doi.org/10.1016/S2225-4110(16)30084-0] [PMID: 24716123]
[11]
Kamiya T, Sameshima-Kamiya M, Nagamine R, et al. The crude extract from Puerariae flower exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice. Evid Based Complement Alternat Med 2012; 2012272710
[http://dx.doi.org/10.1155/2012/272710] [PMID: 22685484]
[http://dx.doi.org/10.1155/2012/272710] [PMID: 22685484]
[12]
Kang K, Lee SB, Jung SH, et al. Tectoridin, a poor ligand of estrogen receptor α, exerts its estrogenic effects via an ERK-dependent pathway. Mol Cells 2009; 27(3): 351-7.
[http://dx.doi.org/10.1007/s10059-009-0045-8] [PMID: 19326083]
[http://dx.doi.org/10.1007/s10059-009-0045-8] [PMID: 19326083]
[13]
Zhang Q-Y, Zheng W, Gul Khaskheli S, Huang W. In vivo evaluation of tectoridin from Puerariae flos on anti-alcoholism property in rats. J Food Nutr Res (Newark) 2019; 7(6): 458-64.
[http://dx.doi.org/10.12691/jfnr-7-6-8]
[http://dx.doi.org/10.12691/jfnr-7-6-8]
[14]
Zhao H, Lv F, Meng W, et al. Anti-hyperlipidemic effect of flavone-rich Belamcanda chinensis (L.) DC. (Iridaceae) leaf extract in ICR mice fed high-fat diet. Trop J Pharm Res 2014; 13(10): 1653.
[http://dx.doi.org/10.4314/tjpr.v13i10.12]
[http://dx.doi.org/10.4314/tjpr.v13i10.12]
[15]
Wang J, Tang Y, Lv X, et al. Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis. Exp Gerontol 2020; 140111057
[http://dx.doi.org/10.1016/j.exger.2020.111057] [PMID: 32798609]
[http://dx.doi.org/10.1016/j.exger.2020.111057] [PMID: 32798609]
[16]
Shim M, Bae J-Y, Lee YJ, Ahn M-J. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors. Phytomedicine 2014; 21(5): 602-6.
[http://dx.doi.org/10.1016/j.phymed.2013.10.022] [PMID: 24252334]
[http://dx.doi.org/10.1016/j.phymed.2013.10.022] [PMID: 24252334]
[17]
Shin JE, Bae E-A, Lee YC, Ma J-Y, Kim D-H. Estrogenic effect of main components kakkalide and tectoridin of Puerariae flos and their metabolites. Biol Pharm Bull 2006; 29(6): 1202-6.
[http://dx.doi.org/10.1248/bpb.29.1202] [PMID: 16755017]
[http://dx.doi.org/10.1248/bpb.29.1202] [PMID: 16755017]
[18]
Xiong Y, Yang Y, Yang J, et al. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice. Toxicology 2010; 276(1): 64-72.
[http://dx.doi.org/10.1016/j.tox.2010.07.007] [PMID: 20637825]
[http://dx.doi.org/10.1016/j.tox.2010.07.007] [PMID: 20637825]
[19]
Lee H-U, Bae E-A, Kim D-H. Hepatoprotective effect of tectoridin and tectorigenin on tert-butyl hyperoxide-induced liver injury. J Pharmacol Sci 2005; 97(4): 541-4.
[http://dx.doi.org/10.1254/jphs.SCZ040467] [PMID: 15821336]
[http://dx.doi.org/10.1254/jphs.SCZ040467] [PMID: 15821336]
[20]
Lee H-W, Choo M-K, Bae E-A, Kim D-H. β-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury Liver Int 2003; 23(4): 221-6.
[http://dx.doi.org/10.1034/j.1600-0676.2003.00830.x] [PMID: 12895260]
[http://dx.doi.org/10.1034/j.1600-0676.2003.00830.x] [PMID: 12895260]
[21]
Jung SH, Lee YS, Lim SS, Lee S, Shin KH, Kim YS. Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats. Arch Pharm Res 2004; 27(2): 184-8.
[http://dx.doi.org/10.1007/BF02980104] [PMID: 15022720]
[http://dx.doi.org/10.1007/BF02980104] [PMID: 15022720]
[22]
Pan C-H, Kim ES, Jung SH, Nho CW, Lee JK. Tectorigenin inhibits IFN-γ/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells. Arch Pharm Res 2008; 31(11): 1447-56.
[http://dx.doi.org/10.1007/s12272-001-2129-7] [PMID: 19023541]
[http://dx.doi.org/10.1007/s12272-001-2129-7] [PMID: 19023541]
[23]
Kim YP, Yamada M, Lim SS, et al. Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochim Biophys Acta 1999; 1438(3): 399-407.
[http://dx.doi.org/10.1016/S1388-1981(99)00067-0] [PMID: 10366782]
[http://dx.doi.org/10.1016/S1388-1981(99)00067-0] [PMID: 10366782]
[24]
Shin KH, Kim YP, Lim SS, et al. Inhibition of prostaglandin E2 production by the isoflavones tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis. Planta Med 1999; 65(8): 776-7.
[http://dx.doi.org/10.1055/s-2006-960868] [PMID: 10630127]
[http://dx.doi.org/10.1055/s-2006-960868] [PMID: 10630127]
[25]
Yamaki K, Kim D-H, Ryu N, Kim YP, Shin KH, Ohuchi K. Effects of naturally occurring isoflavones on prostaglandin E2 production. Planta Med 2002; 68(2): 97-100.
[http://dx.doi.org/10.1055/s-2002-20263] [PMID: 11859455]
[http://dx.doi.org/10.1055/s-2002-20263] [PMID: 11859455]
[26]
Hong J, Shin KH, Lim SS, et al. Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea. Inflamm Allergy Drug Targets 2008; 7(3): 195-202.
[http://dx.doi.org/10.2174/187152808785748100] [PMID: 18782027]
[http://dx.doi.org/10.2174/187152808785748100] [PMID: 18782027]
[27]
Jung SH, Lee YS, Lee S, et al. Anti-angiogenic and anti-tumor activities of isoflavonoids from the rhizomes of Belamcanda chinensis. Planta Med 2003; 69(7): 617-22.
[http://dx.doi.org/10.1055/s-2003-41125] [PMID: 12898416]
[http://dx.doi.org/10.1055/s-2003-41125] [PMID: 12898416]
[28]
Monthakantirat O, De-Eknamkul W, Umehara K, et al. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod 2005; 68(3): 361-4.
[http://dx.doi.org/10.1021/np040175c] [PMID: 15787436]
[http://dx.doi.org/10.1021/np040175c] [PMID: 15787436]
[29]
Lee KT, Sohn IC, Kim YK, et al. Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull 2001; 24(10): 1117-21.
[http://dx.doi.org/10.1248/bpb.24.1117] [PMID: 11642314]
[http://dx.doi.org/10.1248/bpb.24.1117] [PMID: 11642314]
[30]
Xiong L, Guo W, Yang Y, et al. Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway. Mol Cell Biochem 2021; 476(7): 2729-38.
[http://dx.doi.org/10.1007/s11010-021-04081-w] [PMID: 33683556]
[http://dx.doi.org/10.1007/s11010-021-04081-w] [PMID: 33683556]
[31]
Jung SH, Lee YS, Lee S, Lim SS, Kim YS, Shin KH. Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. Arch Pharm Res 2002; 25(3): 306-12.
[http://dx.doi.org/10.1007/BF02976631] [PMID: 12135102]
[http://dx.doi.org/10.1007/BF02976631] [PMID: 12135102]
[32]
Qu J, Wu Z, Gao J, Wen H, Wang T, Yuan D. Excretion of tectoridin metabolites in rat urine and bile orally administrated at different dosages and their inhibitory activity against aldose reductase. Fitoterapia 2014; 99: 99-108.
[http://dx.doi.org/10.1016/j.fitote.2014.09.009] [PMID: 25256063]
[http://dx.doi.org/10.1016/j.fitote.2014.09.009] [PMID: 25256063]
[33]
Moon H-I, Jung J-C, Lee J. Aldose reductase inhibitory effect by tectorigenin derivatives from Viola hondoensis. Bioorg Med Chem 2006; 14(22): 7592-4.
[http://dx.doi.org/10.1016/j.bmc.2006.07.002] [PMID: 16870454]
[http://dx.doi.org/10.1016/j.bmc.2006.07.002] [PMID: 16870454]
[34]
Bae EA, Han MJ, Lee KT, Choi JW, Park HJ, Kim DH. Metabolism of 6”-O-xylosyltectoridin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities. Biol Pharm Bull 1999; 22(12): 1314-8.
[http://dx.doi.org/10.1248/bpb.22.1314] [PMID: 10746163]
[http://dx.doi.org/10.1248/bpb.22.1314] [PMID: 10746163]
[35]
Lee KT, Sohn IC, Kim DH, Choi JW, Kwon SH, Park HJ. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro. Arch Pharm Res 2000; 23(5): 461-6.
[http://dx.doi.org/10.1007/BF02976573] [PMID: 11059824]
[http://dx.doi.org/10.1007/BF02976573] [PMID: 11059824]
[36]
Han T, Cheng G, Liu Y, Yang H, Hu YT, Huang W. In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. Food Chem Toxicol 2012; 50(2): 409-14.
[http://dx.doi.org/10.1016/j.fct.2011.10.066] [PMID: 22079309]
[http://dx.doi.org/10.1016/j.fct.2011.10.066] [PMID: 22079309]
[37]
Bhat GA, Mir F, Shawl AS, et al. Crocetenone, a new rotenoid with an unusual transfused ring system from Iris crocea. Nat Prod Commun 2015; 10(1934578X1501000)
[38]
Tang Y, Li S, Li S, et al. Screening and isolation of potential lactate dehydrogenase inhibitors from five Chinese medicinal herbs: Soybean, Radix pueraria, Flos pueraria, Rhizoma belamcandae, and Radix astragali. J Sep Sci 2016; 39(11): 2043-9.
[http://dx.doi.org/10.1002/jssc.201600050] [PMID: 27059876]
[http://dx.doi.org/10.1002/jssc.201600050] [PMID: 27059876]
[39]
Nirmal N, Praba GO, Velmurugan D. Modeling studies on phospholipase A2-inhibitor complexes. Indian J Biochem Biophys 2008; 45(4): 256-62.
[PMID: 18788476]
[PMID: 18788476]
[40]
Li S, Li S, Tang Y, Liu C, Chen L, Zhang Y. Ultrafiltration-LC-MS combined with semi-preparative HPLC for the simultaneous screening and isolation of lactate dehydrogenase inhibitors from Belamcanda chinensis. J Sep Sci 2016; 39(23): 4533-43.
[http://dx.doi.org/10.1002/jssc.201600703] [PMID: 27734585]
[http://dx.doi.org/10.1002/jssc.201600703] [PMID: 27734585]
[41]
Moon HI, Lee J, Zee OP, Chung JH. A glycosidic isoflavonoid from Viola hondoensis W. BECKER et H. BOISSIEU (Violaceae), and its effect on the expression of matrix metalloproteinase-1 caused by ultraviolet irradiation in cultured human skin fibroblasts. Biol Pharm Bull 2005; 28(6): 1123-5.
[http://dx.doi.org/10.1248/bpb.28.1123] [PMID: 15930761]
[http://dx.doi.org/10.1248/bpb.28.1123] [PMID: 15930761]
[42]
Kim JM, Yun-Choi HS. Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. Arch Pharm Res 2008; 31(7): 886-90.
[http://dx.doi.org/10.1007/s12272-001-1242-1] [PMID: 18704331]
[http://dx.doi.org/10.1007/s12272-001-1242-1] [PMID: 18704331]
[43]
Yuan D, Xie Y-Y, Bai X, Wu X, Yang J-Y, Wu C-F. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. J Asian Nat Prod Res 2009; 11(6): 471-81.
[http://dx.doi.org/10.1080/10286020902819822] [PMID: 20183278]
[http://dx.doi.org/10.1080/10286020902819822] [PMID: 20183278]
[44]
Bidasee KR, Maxwell A, Reynolds WF, Patel V, Besch HR Jr. Tectoridins modulate skeletal and cardiac muscle sarcoplasmic reticulum calcium-release channels. J Pharmacol Exp Ther 2000; 293(3): 1074-83.
[PMID: 10869412]
[PMID: 10869412]
[45]
Chen Y, Song W, Peng ZH, Ge BY, Han FM. Identification of metabolites of tectoridin in-vivo and in-vitro by liquid chromatography-tandem mass spectrometry. J Pharm Pharmacol 2008; 60(6): 709-16.
[http://dx.doi.org/10.1211/jpp.60.6.0005] [PMID: 18498706]
[http://dx.doi.org/10.1211/jpp.60.6.0005] [PMID: 18498706]
[46]
Qu J, Gao J, Sun J, Zhang L, Makino T, Yuan D. Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 902: 61-9.
[http://dx.doi.org/10.1016/j.jchromb.2012.06.017] [PMID: 22771104]
[http://dx.doi.org/10.1016/j.jchromb.2012.06.017] [PMID: 22771104]
[47]
Yang M, Yang X, An J, et al. Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. J Pharm Biomed Anal 2015; 114: 34-41.
[http://dx.doi.org/10.1016/j.jpba.2015.05.005] [PMID: 26004225]
[http://dx.doi.org/10.1016/j.jpba.2015.05.005] [PMID: 26004225]
[48]
Liu T, Chen Z, Guo Y, Jiang X, Ma G. Determination of tectoridin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Biomed Chromatogr 2009; 23(7): 754-8.
[http://dx.doi.org/10.1002/bmc.1180] [PMID: 19296520]
[http://dx.doi.org/10.1002/bmc.1180] [PMID: 19296520]
[49]
Park E-K, Shin Y-W, Lee H-U, Lee CS, Kim D-H. Passive cutaneous anaphylaxis-inhibitory action of tectorigenin, a metabolite of tectoridin by intestinal microflora. Biol Pharm Bull 2004; 27(7): 1099-102.
[http://dx.doi.org/10.1248/bpb.27.1099] [PMID: 15256747]
[http://dx.doi.org/10.1248/bpb.27.1099] [PMID: 15256747]
[50]
Li L, Zhang X, Bu F, Chen N, Zhang H, Gu J. Simultaneous determination of eight constituents in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Shejin-liyan Granule. Biomed Chromatogr 2019; 33(11)e4648
[http://dx.doi.org/10.1002/bmc.4648] [PMID: 31301083]
[http://dx.doi.org/10.1002/bmc.4648] [PMID: 31301083]
[51]
Luo C-F, Yuan M, Chen M-S, et al. Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879(19): 1497-501.
[http://dx.doi.org/10.1016/j.jchromb.2011.03.035] [PMID: 21511546]
[http://dx.doi.org/10.1016/j.jchromb.2011.03.035] [PMID: 21511546]
[52]
Kim SB, Hwang SH, Wang Z, Yu JM, Lim SS. Rapid identification and isolation of inhibitors of rat lens aldose reductase and antioxidant in Maackia amurensis. BioMed Res Int 2017; 20174941825
[http://dx.doi.org/10.1155/2017/4941825] [PMID: 28484711]
[http://dx.doi.org/10.1155/2017/4941825] [PMID: 28484711]
[53]
Qiao W, Wang L, Li H, Li G, Li J, Ye B. Electrochemical behavior of tectoridin and its sensitive determination based on L-arginine modified electrode. Talanta 2015; 144: 726-33.
[http://dx.doi.org/10.1016/j.talanta.2015.07.033] [PMID: 26452883]
[http://dx.doi.org/10.1016/j.talanta.2015.07.033] [PMID: 26452883]
[54]
Mao H, Ye X, Chen W, Geng W, Chen G. Fabrication of carbon nanotube-polylactic acid composite electrode by melt compounding for capillary electrophoretic determination of tectoridin and irigenin in Belamcandae rhizoma. J Pharm Biomed Anal 2019; 175112769
[http://dx.doi.org/10.1016/j.jpba.2019.07.017] [PMID: 31398628]
[http://dx.doi.org/10.1016/j.jpba.2019.07.017] [PMID: 31398628]
[55]
Yao M, Liao Y, Li GQ, Law FCP, Tang Y. Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. Chin Med 2010; 5(1): 14.
[http://dx.doi.org/10.1186/1749-8546-5-14] [PMID: 20416072]
[http://dx.doi.org/10.1186/1749-8546-5-14] [PMID: 20416072]
[56]
Liu L, Li W, Gao Y. Simultaneous determination of tectorigenin-7-O-xylosylglucosid, tectoridin and tectorigenin in flowers of Pueraria lobata by HPLC. Zhongguo Zhongyao Zazhi 2010; 35(17): 2308-11.
[PMID: 21137344]
[PMID: 21137344]
[57]
Li Y, Wang Q, He J, Yan J, Li H. Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: A comparison study. Luminescence 2016; 31(1): 38-46.
[http://dx.doi.org/10.1002/bio.2918] [PMID: 25920391]
[http://dx.doi.org/10.1002/bio.2918] [PMID: 25920391]
[58]
Gu J, Wu W, Huang M, Long F, Liu X, Zhu Y. Application of high-performance liquid chromatography coupled with linear ion trap quadrupole orbitrap mass spectrometry for qualitative and quantitative assessment of shejin-liyan granule supplements. Molecules 2018; 23(4): 884.
[http://dx.doi.org/10.3390/molecules23040884] [PMID: 29641474]
[http://dx.doi.org/10.3390/molecules23040884] [PMID: 29641474]
[59]
Wen Y, He L, Peng R, et al. A novel strategy to evaluate the quality of herbal products based on the chemical profiling, efficacy evaluation and pharmacokinetics. J Pharm Biomed Anal 2018; 161: 326-35.
[http://dx.doi.org/10.1016/j.jpba.2018.08.047] [PMID: 30196209]
[http://dx.doi.org/10.1016/j.jpba.2018.08.047] [PMID: 30196209]
[60]
Sun Y, Liu Z, Wang J. Ultrasound-assisted extraction of five isoflavones from Iris tectorum Maxim. Separ Purif Tech 2011; 78(1): 49-54.
[http://dx.doi.org/10.1016/j.seppur.2011.01.017] [PMID: 32288612]
[http://dx.doi.org/10.1016/j.seppur.2011.01.017] [PMID: 32288612]
[61]
Sun Y, Li W, Wang J. Ionic liquid based ultrasonic assisted extraction of isoflavones from Iris tectorum Maxim and subsequently separation and purification by high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879(13-14): 975-80.
[http://dx.doi.org/10.1016/j.jchromb.2011.03.010] [PMID: 21444254]
[http://dx.doi.org/10.1016/j.jchromb.2011.03.010] [PMID: 21444254]
[62]
Akther N, Andrabi K, Nissar A, et al. Hepatoprotective activity of LC-ESI-MS standardized Iris spuria rhizome extract on its main bioactive constituents. Phytomedicine 2014; 21(10): 1202-7.
[http://dx.doi.org/10.1016/j.phymed.2014.04.007] [PMID: 24877715]
[http://dx.doi.org/10.1016/j.phymed.2014.04.007] [PMID: 24877715]
[63]
Qu J, Chen X, Niu CS, Yu SS. Chemical constituents from Vaccinium bracteatum. Zhongguo Zhongyao Zazhi 2014; 39(4): 684-8.
[PMID: 25204147]
[PMID: 25204147]
[64]
Tarbeeva DV, Fedoreyev SA, Veselova MV, et al. Polyphenolic compounds from callus cultures of iris pseudacorus. Nat Prod Commun 2013; 8(1934578X1300801)
[http://dx.doi.org/10.1177/1934578X1300801020]
[http://dx.doi.org/10.1177/1934578X1300801020]
[65]
Li S, Li S, Liu C, Liu C, Zhang Y. Extraction and isolation of potential anti-stroke compounds from flowers of Pueraria lobata guided by in vitro PC12 cell model. J Chromatogr B Analyt Technol Biomed Life Sci 2017; 1048: 111-20.
[http://dx.doi.org/10.1016/j.jchromb.2017.02.009] [PMID: 28236683]
[http://dx.doi.org/10.1016/j.jchromb.2017.02.009] [PMID: 28236683]
[66]
Hirayama K, Matsuzuka Y, Kamiya T, Ikeguchi M, Takagaki K, Itoh K. Metabolism of isoflavones found in the Pueraria thomsonii flower by human intestinal microbiota. Biosci Microflora 2011; 30(4): 135-40.
[http://dx.doi.org/10.12938/bifidus.30.135] [PMID: 25045319]
[http://dx.doi.org/10.12938/bifidus.30.135] [PMID: 25045319]
[67]
Li X, Li JF, Wang D, Wang WN, Cui Z. Isoflavone glycosides from the bark of Maackia amurensis. Yao Xue Xue Bao 2009; 44(1): 63-8.
[PMID: 19350824]
[PMID: 19350824]
[68]
Xie GY, Chen YJ, Wen R, Xu JY, Wu SS, Qin MJ. Chemical constituents from rhizomes of Iris germanica. Zhongguo Zhongyao Zazhi 2014; 39(5): 846-50.
[PMID: 25204177]
[PMID: 25204177]
[69]
Tsuchihashi R, Kodera M, Sakamoto S, et al. Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains. J Nat Med 2009; 63(3): 254-60.
[http://dx.doi.org/10.1007/s11418-009-0322-z] [PMID: 19219523]
[http://dx.doi.org/10.1007/s11418-009-0322-z] [PMID: 19219523]
[70]
Bai X, Xie Y, Liu J, Qu J, Kano Y, Yuan D. Isolation and identification of urinary metabolites of kakkalide in rats. Drug Metab Dispos 2010; 38(2): 281-6.
[http://dx.doi.org/10.1124/dmd.109.028555] [PMID: 19910516]
[http://dx.doi.org/10.1124/dmd.109.028555] [PMID: 19910516]
[71]
Singab ANB. Flavonoids from Iris spuria (Zeal) cultivated in Egypt. Arch Pharm Res 2004; 27(10): 1023-8.
[http://dx.doi.org/10.1007/BF02975425] [PMID: 15554258]
[http://dx.doi.org/10.1007/BF02975425] [PMID: 15554258]
[72]
Zhang Y-Y, Wang Q, Qi L-W, Qin X-Y, Qin M-J. Characterization and determination of the major constituents in Belamcandae rhizoma by HPLC-DAD-ESI-MS(n). J Pharm Biomed Anal 2011; 56(2): 304-14.
[http://dx.doi.org/10.1016/j.jpba.2011.05.040] [PMID: 21715119]
[http://dx.doi.org/10.1016/j.jpba.2011.05.040] [PMID: 21715119]
[73]
Kim C, Shin S, Ha H, Kim JM. Study of substance changes in flowers of Pueraria thunbergiana Benth. during storage. Arch Pharm Res 2003; 26(3): 210-3.
[http://dx.doi.org/10.1007/BF02976832] [PMID: 12723934]
[http://dx.doi.org/10.1007/BF02976832] [PMID: 12723934]
[74]
Lee YS, Kim SH, Kim JK, Lee S, Jung SH, Lim SS. Preparative isolation and purification of seven isoflavones from Belamcanda chinensis. Phytochem Anal 2011; 22(5): 468-73.
[http://dx.doi.org/10.1002/pca.1306] [PMID: 21465599]
[http://dx.doi.org/10.1002/pca.1306] [PMID: 21465599]
[75]
Tang W-T, Fang M-F, Liu X, Yue M. Simultaneous quantitative and qualitative analysis of flavonoids from ultraviolet-b radiation in leaves and roots of Scutellaria baicalensis georgi using LC-UV-ESI-Q/TOF/MS. J Anal Methods Chem 2014; 2014643879
[http://dx.doi.org/10.1155/2014/643879] [PMID: 24757579]
[http://dx.doi.org/10.1155/2014/643879] [PMID: 24757579]
[76]
Wang Q, Cheng X-L, Li H, et al. Application of an efficient strategy for discovery and purification of bioactive compounds from Chinese herbal medicines, a case study on the Puerariae thomsonii Flos. J Pharm Biomed Anal 2013; 75: 25-32.
[http://dx.doi.org/10.1016/j.jpba.2012.11.009] [PMID: 23312381]
[http://dx.doi.org/10.1016/j.jpba.2012.11.009] [PMID: 23312381]
[77]
Niiho Y, Nakajima Y, Yamazaki T, et al. Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside. J Nat Med 2010; 64(3): 313-20.
[http://dx.doi.org/10.1007/s11418-010-0411-z] [PMID: 20354803]
[http://dx.doi.org/10.1007/s11418-010-0411-z] [PMID: 20354803]
[78]
Liu L, Ma Y, Chen X, Xiong X, Shi S. Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe3O4 magnetic nanoparticles coupled with HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 887-888: 55-60.
[http://dx.doi.org/10.1016/j.jchromb.2012.01.008] [PMID: 22305973]
[http://dx.doi.org/10.1016/j.jchromb.2012.01.008] [PMID: 22305973]
[79]
Chen Y, Wu C-M, Dai R-J, et al. Combination of HPLC chromatogram and hypoglycemic effect identifies isoflavones as the principal active fraction of Belamcanda chinensis leaf extract in diabetes treatment. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879(5-6): 371-8.
[http://dx.doi.org/10.1016/j.jchromb.2010.12.022] [PMID: 21239237]
[http://dx.doi.org/10.1016/j.jchromb.2010.12.022] [PMID: 21239237]
[80]
Zhou L-X, Lin M. A new stilbene dimer--shegansu B from Belamcanda chinensis. J Asian Nat Prod Res 2000; 2(3): 169-75.
[http://dx.doi.org/10.1080/10286020008039908] [PMID: 11256690]
[http://dx.doi.org/10.1080/10286020008039908] [PMID: 11256690]
[81]
Li J, Li WZM, Huang W, et al. Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. J Chromatogr A 2009; 1216(11): 2071-8.
[http://dx.doi.org/10.1016/j.chroma.2008.05.082] [PMID: 18550076]
[http://dx.doi.org/10.1016/j.chroma.2008.05.082] [PMID: 18550076]
[82]
Ma L, Song ZW, Wu F. Determination of five isoflavones in Belamcanda chinensis by RP-HPLC. Yao Xue Xue Bao 1996; 31(12): 945-9.
[PMID: 9863225]
[PMID: 9863225]
[83]
Qiu Q hao, Zhang Z guo, Wang J hua, Lv T sheng. Studies on the isoflavonoids of Iris tectorum. Zhong Yao Cai 2009; 32: 1392-4.
[84]
Zhou X, Wang L, Tian Y, Gong XJ, Zhao C, Yang SL. Chemical constituents from roots of Psammosilene tunicoides. Zhongguo Zhongyao Zazhi 2013; 38(20): 3507-9.
[PMID: 24490563]
[PMID: 24490563]
[85]
Wu YX, Xu LX. Analysis of isoflavones in Belamcanda chinensis (L.)DC. and Iris tectorum Maxim by square wave voltammetry. Yao Xue Xue Bao 1992; 27(1): 64-8.
[PMID: 1529717]
[PMID: 1529717]
[86]
Jiang Y, Zhao W, Feng C, Zhou T, Fan G, Wu Y. Isolation and purification of isoflavonoids from Rhizoma Belamcandae by two-dimensional preparative high-performance liquid chromatography with column switch technology. Biomed Chromatogr 2009; 23(10): 1064-72.
[http://dx.doi.org/10.1002/bmc.1224] [PMID: 19382246]
[http://dx.doi.org/10.1002/bmc.1224] [PMID: 19382246]
[87]
Lin C-C, Wang Y-Y, Chen S-M, et al. Shegan-Mahuang Decoction ameliorates asthmatic airway hyperresponsiveness by downregulating Th2/Th17 cells but upregulating CD4+FoxP3+ Tregs. J Ethnopharmacol 2020; 253112656
[http://dx.doi.org/10.1016/j.jep.2020.112656] [PMID: 32035217]
[http://dx.doi.org/10.1016/j.jep.2020.112656] [PMID: 32035217]
[88]
Wozniak D, Janda B, Kapusta I, Oleszek W, Matkowski A. Antimutagenic and anti-oxidant activities of isoflavonoids from Belamcanda chinensis (L.) DC. Mutat Res 2010; 696(2): 148-53.
[http://dx.doi.org/10.1016/j.mrgentox.2010.01.004] [PMID: 20096370]
[http://dx.doi.org/10.1016/j.mrgentox.2010.01.004] [PMID: 20096370]
[89]
Liu M, Yang S, Jin L, Hu D, Wu Z, Yang S. Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. Molecules 2012; 17(5): 6156-69.
[http://dx.doi.org/10.3390/molecules17056156] [PMID: 22627971]
[http://dx.doi.org/10.3390/molecules17056156] [PMID: 22627971]
[90]
Wei Z, Yu X, Zhang Y, Wang Y, Zhang H, Wang S, et al. Studies on chemical constituents of Flos Puerariae‐Semen Hoveniae medicine pair by HPLC and Fourier transform ion cyclotron resonance mass spectrometry. J Sep Sci 2022; 45(2): 477-91.
[PMID: 34741585]
[PMID: 34741585]
[91]
Liu J, Xia T-R. Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties. Xenobiotica 2021; 51(6): 680-8.
[http://dx.doi.org/10.1080/00498254.2021.1907473] [PMID: 33779496]
[http://dx.doi.org/10.1080/00498254.2021.1907473] [PMID: 33779496]
[92]
Mykhailenko O, Korinek M, Ivanauskas L, et al. Qualitative and quantitative analysis of ukrainian Iris species: A fresh look on their antioxidant content and biological activities. Molecules 2020; 25(19): 4588.
[http://dx.doi.org/10.3390/molecules25194588] [PMID: 33050063]
[http://dx.doi.org/10.3390/molecules25194588] [PMID: 33050063]
[93]
Ikewuchi JC, Ikewuchi CC, Ifeanacho MO. Nutrient and bioactive compounds composition of the leaves and stems of Pandiaka heudelotii: A wild vegetable. Heliyon 2019; 5(4)e01501
[http://dx.doi.org/10.1016/j.heliyon.2019.e01501] [PMID: 31025012]
[http://dx.doi.org/10.1016/j.heliyon.2019.e01501] [PMID: 31025012]
[94]
Orief YI, Farghaly NF, Ibrahim MIA. Use of herbal medicines among pregnant women attending family health centers in Alexandria. Middle East Fertil Soc J 2014; 19(1): 42-50.
[http://dx.doi.org/10.1016/j.mefs.2012.02.007]
[http://dx.doi.org/10.1016/j.mefs.2012.02.007]
[95]
Patel K, Kumar V, Verma A, Rahman M, Patel DK. Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery. Recent Pat Antiinfect Drug Discov 2019; 14(1): 7-15.
[http://dx.doi.org/10.2174/1574891X13666180913154355] [PMID: 30210007]
[http://dx.doi.org/10.2174/1574891X13666180913154355] [PMID: 30210007]
[96]
Patel K, Gadewar M, Tahilyani V, Patel DK. A review on pharmacological and analytical aspects of diosmetin: A concise report. Chin J Integr Med 2013; 19(10): 792-800.
[http://dx.doi.org/10.1007/s11655-013-1595-3] [PMID: 24092244]
[http://dx.doi.org/10.1007/s11655-013-1595-3] [PMID: 24092244]
[97]
Firenzuoli F, Gori L. Herbal medicine today: Clinical and research issues. Evid Based Complement Alternat Med 2007; 4(s1)(Suppl. 1): 37-40.
[http://dx.doi.org/10.1093/ecam/nem096] [PMID: 18227931]
[http://dx.doi.org/10.1093/ecam/nem096] [PMID: 18227931]
[98]
Jang GH, Kim HW, Lee MK, et al. Characterization and quantification of flavonoid glycosides in the Prunus genus by UPLC-DAD-QTOF/MS. Saudi J Biol Sci 2018; 25(8): 1622-31.
[http://dx.doi.org/10.1016/j.sjbs.2016.08.001] [PMID: 30591779]
[http://dx.doi.org/10.1016/j.sjbs.2016.08.001] [PMID: 30591779]
[99]
Patel K, Jain A, Patel DK. Medicinal significance, pharmacological activities, and analytical aspects of anthocyanidins ‘delphinidin’: A concise report. J Acute Dis 2013; 2(3): 169-78.
[http://dx.doi.org/10.1016/S2221-6189(13)60123-7]
[http://dx.doi.org/10.1016/S2221-6189(13)60123-7]
[100]
Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules 2016; 21(5): 559.
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[101]
Singh B, Sahu PM, Sharma RA. Flavonoids from Heliotropium subulatum exudate and their evaluation for antioxidant, antineoplastic and cytotoxic activities II. Cytotechnology 2017; 69(1): 103-15.
[http://dx.doi.org/10.1007/s10616-016-0041-8] [PMID: 27905025]
[http://dx.doi.org/10.1007/s10616-016-0041-8] [PMID: 27905025]
[102]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. New insights into the medicinal importance, physiological functions and bioanalytical aspects of an important bioactive compound of foods ‘Hyperin’: Health benefits of the past, the present, the future. Beni Suef Univ J Basic Appl Sci 2018; 7(1): 31-42.
[http://dx.doi.org/10.1016/j.bjbas.2017.05.009]
[http://dx.doi.org/10.1016/j.bjbas.2017.05.009]
[103]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. Rhamnazin: A systematic review on ethnopharmacology, pharmacology and analytical aspects of an important phytomedicine. Curr Tradit Med 2018; 4(2): 120-7.
[http://dx.doi.org/10.2174/2215083804666180416124949]
[http://dx.doi.org/10.2174/2215083804666180416124949]
[104]
Asati V, Sharma PK. Purification and characterization of an isoflavones conjugate hydrolyzing β-glucosidase (ICHG) from Cyamopsis tetragonoloba (guar). Biochem Biophys Rep 2019; 20100669
[http://dx.doi.org/10.1016/j.bbrep.2019.100669] [PMID: 31453384]
[http://dx.doi.org/10.1016/j.bbrep.2019.100669] [PMID: 31453384]
[105]
Li Y, Tang P, Xu K, Li S, Guo L, Li H. X-ray powder diffraction data for tectoridin, C 22 H 22 O 11. Powder Diffr 2016; 31(1): 52-4.
[http://dx.doi.org/10.1017/S0885715615000810]
[http://dx.doi.org/10.1017/S0885715615000810]
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