Abstract
Background: Psoralea corylifolia Linn belongs to the Leguminosae family and is commonly known as ‘Bakuchi’ in the Ayurvedic system of medicine. P. corylifolia is an important medicinal herb used for the treatment of leucoderma, psoriasis, and leprosy. P. corylifolia seed contain psoralen, psoralidin, isopsoralen, neobavaisoflavone, corylin, bavachin, and bavachalcone. P. corylifolia has been used for the treatment of asthma, vitiligo, nephritis, calvities, and cough. Bavachin is a pure phytochemical found to be present in the seeds and fruit of P. corylifolia.
Methods: In order to know the medicinal properties and therapeutic benefits of bavachin, numerous scientific research data have been collected and analyzed from different literature sources. The medicinal importance and pharmacological activities of bavachin have been investigated through literature data analysis of different scientific research works. Scientific research data has been collected from databases such as PubMed, Google, Google Scholar, Science Direct, and Scopus using the words Psoralea corylifolia and bavachin. Scientific articles on bavachin with respect to its pharmacological activities, medicinal importance, and analytical data have been collected from these databases and presented here with proper citation.
Results: Data analysis of scientific research works on bavachin revealed the biological importance of bavachin in medicine. Bavachin showed anti-inflammatory, anticancer, anti-bacterial, lipidlowering, and cholesterol-reducing properties. Bavachin has multiple pharmacological activities, including platelet aggregation, α-glucosidase activities, and antibacterial potential. Bavachin has a potential estrogen supplement for estrogen replacement therapy. Present work summarized the biological potential of bavachin on inflammatory disorders, articular cartilage degeneration, cardiovascular disease, hyperglycemia, Parkinson's disease, Alzheimer's disease, apoptosis, melanin synthesis, estrogen receptor, UDP-glucuronosyltransferase 1A1, and various forms of pathogenic infection. Analytical data revealed the significance of HPLC-UV, HPLC, HPLC-ECD, HPLCDAD, IT-MS, HPLC, HPLC/TOF-MS, LC-MS/MS, and ILUAE techniques for separation, identification, and quantification of bavachin in different samples.
Conclusion: Literature data analysis revealed the biological importance and therapeutic potential of bavachin in medicine for the treatment of various forms of human disorders.
Keywords: Bioactive material, bavachin, herbal product, P. corylifolia, human disorders, analytical techniques, pharmacological properties.
Graphical Abstract
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