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Review Article

基于生物材料修饰的微/纳米气泡超声靶向给药系统治疗肿瘤的研究进展与展望

卷 29, 期 30, 2022

发表于: 20 May, 2022

页: [5062 - 5075] 页: 14

弟呕挨: 10.2174/0929867329666220331110315

价格: $65

摘要

恶性肿瘤的发病率正在迅速上升，而且往往在较年轻，这一直是危及人类生命安全的最重要因素之一。超声微/纳米气泡作为一种无创和高度特异性的抗肿瘤策略，可以在超声的指导下通过其空化和声穿孔的作用到达并破坏肿瘤组织。同时，微/纳米气泡现在被用作一种新型药物载体，在目标区域释放药物，特别是生物材料修饰的微/纳米气泡作为药物递送和治疗监测的双重模式的前景。在将该技术应用于临床之前，需要对超声穿孔机制、超声参数、药物类型和剂量进行成功评估。因此，本文收集了近年来超声生物材料修饰微纳气泡治疗体外和体内实验和临床研究的文献。

关键词: 超声波，微/纳米气泡，靶向，药物递送系统，分子递送，肿瘤治疗，生物材料。

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