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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Research Article

The Effects of Acute and Chronic Sleep Deprivation on the Immune Profile in the Rat

Author(s): Alaa Fahmawi, Mohammad S. Khalifeh, Karem H. Alzoubi* and Abeer M. Rababa’h

Volume 16, Issue 1, 2023

Published on: 13 May, 2022

Article ID: e160322202280 Pages: 8

DOI: 10.2174/1874467215666220316104321

Price: $65

Abstract

Background: Acute and chronic sleep deprivation present many health-related problems in modern societies, mainly concerning the immune system. Immune factors, particularly the interleukins, regulate sleep and, therefore, may be altered by sleep deprivation (SD). Objectives: We aimed to investigate the possible effects of acute and chronic sleep deprivation on selected cytokines, including interleukins (IL-1β, IL-9, IL-17, and IL-23) and tumor necrosis factor- alpha (TNF-α).

Methods: The animals were grouped into acute sleep-deprived (SD; for 24 hours) and chronic sleep-deprived (8 hours a day for 10, 20, and 30-days). The SD was induced using the multipleplatforms model. The serum levels of cytokines were measured using commercially available ELISA.

Results: The serum levels of IL-1β were significantly reduced after acute SD, whereas they were increased after 20-days of chronic SD. The IL-9 levels were reduced after acute SD, increased after 10-days of SD, and reduced again after 30-days of SD. Conversely, the levels of IL-23 were not changed after acute SD, reduced after 10 days of SD, and increased after 30-days of SD. Levels of TNF-α were not changed after acute SD, whereas they were increased after 20 and 30- days of SD.

Conclusion: In conclusion, both acute and chronic SD distinctly disturb the immune profile, which might result in the emergence of various pathologies presented during sleep deprivation.

Keywords: Sleep deprivation, cytokines, interleukins, rat model, platform, immune profile.

Graphical Abstract

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