摘要
利什曼病是一种由利什曼原虫属原生动物引起的皮肤、粘膜或内脏寄生虫病,每年造成约2 -4万人死亡,其中巴西、印度和非洲某些国家受影响最严重。除了寄生虫能够逃避宿主的免疫系统外,媒介的发病率、不同宿主的基因和几起死亡事件都归因于有限的传统治疗,这些治疗具有高毒性、低有效性和长时间的治疗方案。因此,发展新的替代治疗策略仍然是必要的。金属纳米颗粒,如金、银、氧化锌和二氧化钛,由于易于制备和化学修饰,具有广泛的作用谱和低毒性,并可产生活性氧和其他免疫反应,已显示出有前途的治疗工具。本文综述了利用金属纳米颗粒作为治疗利什曼病的新工具的进展,并讨论了阻碍开发安全有效的治疗这些感染的知识空白。
关键词: 利什曼病,纳米颗粒,纳米治疗,金属纳米颗粒,被忽视的疾病,治疗。
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