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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

The Applications of Sulfinic Acids, Sodium Sulfinates, or Sulfonyl Hydrazides in the Radical Cyclization

Author(s): Yangyang Li, Dayun Huang, Danfeng Deng* and Sheng-Rong Guo*

Volume 26, Issue 4, 2022

Published on: 10 March, 2022

Page: [369 - 381] Pages: 13

DOI: 10.2174/1385272826666220222110614

Price: $65

Abstract

Sulfinic acids, sodium sulfinates, and sulfonyl hydrazides are stable, inexpensive, and readily available building blocks, which have been recently utilized as synthons to access various heterocyclic motifs via radical sulfonylation and cyclization. This review systematically summarizes the radical cyclization cascades and discusses their mechanisms. Moreover, it also discusses multi-component reactions, rearrangements, cycloadditions, coupling, green chemistry, etc. We hope that this review will promote future research in this area.

Keywords: Sulfonylation, cyclization, ketones, sulfinic acid, sodium sulfinate, sulfonyl hydrazide.

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