Login Register Cart 0
Generic placeholder image

Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Perspective

Mechanochemistry - A Promising Tool on the Synthesis of Organometallic Pincer Compounds: Current State and Future Perspectives

Author(s): Valente Gómez-Benítez, Juan Manuel Germán-Acacio* and David Morales-Morales*

Volume 26, Issue 5, 2022

Published on: 06 April, 2022

Page: [438 - 443] Pages: 6

DOI: 10.2174/1385272826666220214110600

Abstract

Among the different synthetic procedures available where the reactivity of substances is exploited using solid-state chemistry, such as microwave irradiation, ultrasound (sonochemistry), photochemistry, and mechanochemistry, the latter stands out as a synthetic tool in various areas of chemistry and materials sciences, acquiring great relevance in recent years. Thus, mechanochemistry has been applied in different areas, such as organic synthesis, preparation of metal complexes, multicomponent pharmaceutical solid forms, catalysis, polymers, etc. However, despite the attractiveness of this sustainable technique, its application in the synthesis of coordination and organometallic compounds has been very incipient. On the other hand, pincer compounds have been a privileged ligand platform that has been profusely used for the synthesis of organometallic and coordination compounds for the last 20 years, finding applications in a large number of areas of chemistry, this being particularly true in the case of catalysis, being able to activate bonds difficult to activate, such as C-H bonds, due in part to their characteristic thermal robustness. Thus, on this perspective paper, we present the current state of mechanochemistry in the preparation of organometallic pincer compounds and discuss future perspectives for the synthesis of these foremost interesting species via mechanochemistry.

Keywords: Mechanochemistry, pincer complexes, ball-milling, catalysis, solid–state reactions, sustainability, cyclometallation, green chemistry.

« Previous Next »
Graphical Abstract

[1]
Solares-Briones, M.; Coyote-Dotor, G.; Páez-Franco, J.C.; Zermeño-Ortega, M.R. de la O Contreras, C.M.; Canseco-González, D.; Avila-Sorrosa, A.; Morales-Morales, D.; Germán-Acacio, J.M. Mechanochemistry: A green ap-proach in the preparation of pharmaceutical cocrystals. Pharmaceutics, 2021, 13(6), 790.
[http://dx.doi.org/10.3390/pharmaceutics13060790] [PMID: 34070646]
[2]
Gomollón-Bel, F. Ten chemical innovations that will change our world. Chem. Int., 2019, 41, 12-17.
[http://dx.doi.org/10.1515/ci-2019-0203]
[3]
Michalchuk, A.A.L.; Boldyreva, E.V.; Belenguer, A.M.; Emmerling, F.; Boldyrev, V.V. Tribochemistry, mechanical alloying, mechanochemistry: What is in a name? Front Chem., 2021, 9, 685789.
[http://dx.doi.org/10.3389/fchem.2021.685789] [PMID: 34164379]
[4]
Lapshin, O.V.; Boldyreva, E.V.; Boldyrev, V.V. Role of mixing and milling in mechanochemical synthesis. Russ. J. Inorg. Chem., 2021, 66, 433-453.
[http://dx.doi.org/10.1134/S0036023621030116]
[5]
Do, J.L. Fricic T. Chemistry 20: Developing a new, solvent-free system of chemical synthesis based on mechanochemistry. Synlett, 2017, 28, 2066-2092.
[http://dx.doi.org/10.1055/s-0036-1590854]
[6]
Rightmire, N.R.; Hanusa, T.P. Advances in organometallic synthesis with mechanochemical methods. Dalton Trans., 2016, 45(6), 2352-2362.
[http://dx.doi.org/10.1039/C5DT03866A] [PMID: 26763151]
[7]
Ivanov, D.M.; Gushchin, P.V.; Novikov, A.S.; Avdontceva, M.S.; Zolotarev, A.A.; Starova, G.L.; Chen, Y-T.; Liu, S-H.; Chou, P-T.; Kukushkin, V.Y. Platinum(II)-mediated double coupling of 2,3-diphenylmaleimidine with nitrile functionalities to give annulated pentaazanonatetraenate (PANT) systems. Eur. J. Inorg. Chem., 2016, 1480-1487.
[http://dx.doi.org/10.1002/ejic.201501398]
[8]
Valdés, H.; García-Eleno, M.A.; Canseco-Gonzalez, D.; Morales-Morales, D. Recent advances in catalysis with transition-metal pincer compounds. ChemCatChem, 2018, 10, 3136-3172.
[http://dx.doi.org/10.1002/cctc.201702019]
[9]
Valdés, H.; Rufino-Felipe, E.; van Koten, G.; Morales-Morales, D. Hybrid POCZP Aryl pincer metal complexes and their catalytic applications. Eur. J. Inorg. Chem., 2020, 4418-4424.
[http://dx.doi.org/10.1002/ejic.202000817]
[10]
Asay, M.; Morales-Morales, D. Recent advances on the chemistry of POC-OP–nickel pincer compounds. Top. Organomet. Chem., 2016, 54, 239-268.
[http://dx.doi.org/10.1007/3418_2015_135]
[11]
Asay, M.; Morales-Morales, D. Non-symmetric pincer ligands: Complexes and applications in catalysis. Dalton Trans., 2015, 44(40), 17432-17447.
[http://dx.doi.org/10.1039/C5DT02295A] [PMID: 26396037]
[12]
Valdes, H.; German-Acacio, J.M.; van Koten, G. MoralesMorales, D. Bime-tallic complexes that merge metallocene and pincer-metal building blocks: Synthesis, stereochemistry and catalytic reactivity. Dalton Trans., 2022, 51(5), 1724-1744.
[http://dx.doi.org/10.1039/D1DT03870B]
[13]
Morales-Morales, D., Ed.; Pincer Compounds Chemistry and Applications; Elsevier: The Netherlands, 2018.
[http://dx.doi.org/10.1016/C2016-0-02374-4]
[14]
Morales-Morales, D.; Jensen, C.M., Eds.; The Chemistry of Pincer Com-pounds; Elsevier: The Netherlands, 2007.
[http://dx.doi.org/10.1016/B978-0-444-53138-4.X5001-6]
[15]
Kozlov, V.A.; Aleksanyan, D.V.; Korobov, M.V.; Avramenko, N.V.; Aysin, R.R.; Maloshitskaya, O.A.; Korlyukov, A.S.; Odinets, I.L. The first solid phase synthesis of pincer palladium complexes. Dalton Trans., 2011, 40(35), 8768-8772.
[http://dx.doi.org/10.1039/c1dt10680e] [PMID: 21643616]
[16]
Aleksanyan, D.V.; Churusova, S.G.; Aysin, R.R.; Klemenkova, Z.S.; Ne-lyubina, Y.V.; Kozlov, V.A. The first example of mechanochemical synthe-sis of organometallic pincer complexes. Inorg. Chem. Commun., 2017, 76, 33-35.
[http://dx.doi.org/10.1016/j.inoche.2016.12.006]
[17]
Eppel, D. Eryigit, A.; Rudolph, M.; Brückner, M.; Rominger, F.; Asiri, A.M.; Hashmi, A.S.K. Mechanochemical Gold(III)-carbon bond formation. Angew. Chem. Int. Ed. Engl., 2021, 60(24), 13636-13640.
[http://dx.doi.org/10.1002/anie.202017065] [PMID: 33825267]
[18]
Aleksanyan, D.V.; Churusova, S.G.; Brunova, V.V.; Peregudov, A.S.; Shakhov, A.M.; Rybalkina, E.Y.; Klemenkova, Z.S.; Kononova, E.G.; Den-isov, G.L.; Kozlov, V.A. Mechanochemistry for the synthesis of non-classical N-metalated palladium(II) pincer complexes. Dalton Trans., 2021, 50(45), 16726-16738.
[http://dx.doi.org/10.1039/D1DT03259C] [PMID: 34761776]

Rights & Permissions Print Cite
Article Metrics
24
1
© 2024 Bentham Science Publishers | Privacy Policy