Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

An Overview of Biotechnological Applications in Ayurveda: Amalgamation of Modern Techniques and Science

Author(s): Ashutosh Chauhan*, Deepak Kumar Semwal and Sunil Kumar Joshi

Volume 9, Issue 1, 2023

Published on: 27 August, 2022

Article ID: e110222201080 Pages: 10

DOI: 10.2174/2215083808666220211161918

Price: $65

Abstract

Health systems and their trends are continually evolving with advanced research on new tools and techniques. Since every health system has its limitations, there is a requirement for the integration of different medical systems to better serve mankind. In this direction, a practitioner of modern medicine should take into consideration traditional medicine practices, while the traditional medicine practitioner should also integrate the beneficial strategies of modern medicine. In spite of different approaches, the aim of all these medical systems is the same, which is to serve mankind by treating various health problems. Although traditional medicine has the potential to treat a variety of diseases, its acceptance by the global community is less than that of modern medicine due to inadequate scientific validation of its therapeutic benefits. In recent years, many new diseases have emerged, perhaps due to changes in geography, environment, weather conditions, and soil composition. A complete treatment of such diseases is a challenge for all medical practitioners, whether belonging to modern or traditional medicine. Therefore, an in-depth multidisciplinary research is needed to find an effective therapeutic strategy by connecting modern and traditional medical systems with biomedical sciences. In this direction, biotechnology can play an important role in developing a diagnostic method and treatment protocol. The present review provides an overview of the available Ayurvedic treatment options and future possibilities in which biotechnology may assist as a service provider.

Keywords: Western medicine, Traditional medicine, Ayurveda, Biotechnology, World Health Organization (WHO), artemisinin

Graphical Abstract

[1]
Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med 2011; 17(10): 1217-20.
[http://dx.doi.org/10.1038/nm.2471] [PMID: 21989013]
[2]
Patwardhan B, Tillu G. A tribute to the visionaries. J Ayurveda Integr Med 2018; 9(3): 159-60.
[http://dx.doi.org/10.1016/j.jaim.2018.08.005] [PMID: 30244766]
[3]
W.H.O. Benchmarks for training in traditional/ complementary and alternative medicine: benchmarks for training in traditional Chinese medicine. World Health Organization. 2010. Available from: https://apps.who.int/iris/handle/10665/44353
[4]
Chatterjee B, Pancholi J. Prakriti-based medicine: A step towards personalized medicine. Ayu 2011; 32(2): 141-6.
[http://dx.doi.org/10.4103/0974-8520.92539] [PMID: 22408293]
[5]
Chaudhary A, Singh N. Contribution of world health organization in the global acceptance of Ayurveda. J Ayurveda Integr Med 2011; 2(4): 179-86.
[http://dx.doi.org/10.4103/0975-9476.90769] [PMID: 22253507]
[6]
Sekar S. Traditional alcoholic beverages from Ayurveda and their role on human health. Indian J Tradit Knowl 2007; 6(1): 144-9.
[7]
Katiyar CK. Ayurpathy: A modern perspective of Ayurveda. Ayu 2011; 32(3): 304-5.
[http://dx.doi.org/10.4103/0974-8520.93903] [PMID: 22529640]
[8]
Verma AS, Agrahari S, Rastogi S, Singh A. Biotechnology in the realm of history. J Pharm Bioallied Sci 2011; 3(3): 321-3.
[http://dx.doi.org/10.4103/0975-7406.84430] [PMID: 21966150]
[9]
Sótonyi G. Participation of hungarians in the elaboration of principles of genetics and of biotehchnology. Orvostort Kozl 2015; 61(1-4): 125-36.
[PMID: 26875293]
[10]
Joshi K, Ghodke Y, Shintre P. Traditional medicine and genomics. J Ayurveda Integr Med 2010; 1(1): 26-32.
[http://dx.doi.org/10.4103/0975-9476.59824] [PMID: 21829298]
[11]
Bhushan P, Kalpana J, Arvind C. Classification of human population based on HLA gene polymorphism and the concept of Prakriti in Ayurveda. J Altern Complement Med 2005; 11(2): 349-53.
[http://dx.doi.org/10.1089/acm.2005.11.349] [PMID: 15865503]
[12]
Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda prakriti typeand CYP2C19 gene polymorphism associated with the metabolic variability. Evid Based Complement Alternat Med 2011; 2011249528
[http://dx.doi.org/10.1093/ecam/nep206] [PMID: 20015960]
[13]
Prasher B, Negi S, Aggarwal S, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med 2008; 6: 48.
[http://dx.doi.org/10.1186/1479-5876-6-48] [PMID: 18782426]
[14]
Prasher B, Varma B, Kumar A, et al. Ayurgenomics for stratified medicine: TRISUTRA consortium initiative across ethnically and geographically diverse Indian populations. J Ethnopharmacol 2017; 197: 274-93.
[http://dx.doi.org/10.1016/j.jep.2016.07.063] [PMID: 27457695]
[15]
Blackstock WP, Weir MP. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol 1999; 17(3): 121-7.
[http://dx.doi.org/10.1016/S0167-7799(98)01245-1] [PMID: 10189717]
[16]
Anderson JD, Johansson HJ, Graham CS, et al. Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-κB signaling. Stem Cells 2016; 34(3): 601-13.
[http://dx.doi.org/10.1002/stem.2298] [PMID: 26782178]
[17]
Wang C, Wan Y, Luo X, et al. Regulative mechanism of Chinese herbal medicine on cell signaling pathway in kidney. Zhongguo Zhongyao Zazhi 2011; 36(1): 85-91.
[PMID: 21473159]
[18]
Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C. Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. Mol Cancer Ther 2010; 9(1): 202-10.
[http://dx.doi.org/10.1158/1535-7163.MCT-09-0771] [PMID: 20053782]
[19]
Bhandari M, Ravipati AS, Reddy N, et al. Traditional Ayurvedic medicines: pathway to develop anti-cancer drugs. J Mol Pharm Org Process Res 2015; 3(3)100130
[20]
Chauhan A, Semwal DK, Mishra SP, Semwal RB. Ayurvedic concept of Shatkriyakala: a traditional knowledge of cancer pathogenesis and therapy. J Integr Med 2017; 15(2): 88-94.
[http://dx.doi.org/10.1016/S2095-4964(17)60311-X] [PMID: 28285613]
[21]
Mukerji M, Prasher B. Ayurgenomics: a new approach in personalized and preventive medicine. Sci Cult 2011; 77: 10-7.
[22]
Rotti H, Raval R, Anchan S, et al. Determinants of prakriti, the human constitution types of Indian traditional medicine and its correlation with contemporary science. J Ayurveda Integr Med 2014; 5(3): 167-75.
[PMID: 25336848]
[23]
Patwardhan B, Chaguturu R. Innovative approaches in drug discovery: Ethnopharmacology. J Ayurveda Integr Med 2019; 10(2): 143-5.
[24]
Rastogi S. Building bridges between Ayurveda and modern science. Int J Ayurveda Res 2010; 1(1): 41-6.
[http://dx.doi.org/10.4103/0974-7788.59943] [PMID: 20532097]
[25]
Kumar A, Nair AG, Reddy AV, Garg AN. Bhasmas: unique ayurvedic metallic-herbal preparations, chemical characterization. Biol Trace Elem Res 2006; 109(3): 231-54.
[http://dx.doi.org/10.1385/BTER:109:3:231] [PMID: 16632893]
[26]
Wadekar MP, Rode CV, Bendale YN, Patil KR, Prabhune AA. Preparation and characterization of a copper based Indian traditional drug: tamra bhasma. J Pharm Biomed Anal 2005; 39(5): 951-5.
[http://dx.doi.org/10.1016/j.jpba.2005.06.015] [PMID: 16095857]
[27]
Andersen ML, Winter LMF. Animal models in biological and biomedical research - experimental and ethical concerns. An Acad Bras Cienc 2019; 91 (Suppl. 1).e20170238
[http://dx.doi.org/10.1590/0001-3765201720170238] [PMID: 28876358]
[28]
Barré-Sinoussi F, Montagutelli X. Animal models are essential to biological research: issues and perspectives. Future Sci OA 2015; 1(4): FSO63.
[http://dx.doi.org/10.4155/fso.15.63] [PMID: 28031915]
[29]
Mather JP. Introduction to cell and tissue culture. Boston: Springer 1998; pp. 165-74.
[30]
Delzenne NM, Cani PD, Everard A, Neyrinck AM, Bindels LB. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia 2015; 58(10): 2206-17.
[http://dx.doi.org/10.1007/s00125-015-3712-7] [PMID: 26224102]
[31]
David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014; 505(7484): 559-63.
[http://dx.doi.org/10.1038/nature12820] [PMID: 24336217]
[32]
Singh RH. Foundations of immunology in Ayurvedic classics. Indian J Hist Sci 2015; 50(1): 83-94.
[http://dx.doi.org/10.16943/ijhs/2015/v50i1/48113]
[33]
Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect 2012; 45(3): 165-84.
[http://dx.doi.org/10.1016/j.jmii.2011.09.030] [PMID: 22154993]
[34]
Gupta BP, Sharma I, Kohli N, Sharma S, Rathi A, Sharma AK. Preliminary clinical assessment and non- toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM. J Tradit Complement Med 2018; 8(4): 506-14.
[http://dx.doi.org/10.1016/j.jtcme.2017.11.004] [PMID: 30302331]
[35]
Mahima RA, Rahal A, Deb R, et al. Immunomodulatory and therapeutic potentials of herbal, traditional/indigenous and ethnoveterinary medicines. Pak J Biol Sci 2012; 15(16): 754-74.
[http://dx.doi.org/10.3923/pjbs.2012.754.774] [PMID: 24175417]
[36]
Olson JE, Bielinski SJ, Ryu E, et al. Biobanks and personalized medicine. Clin Genet 2014; 86(1): 50-5.
[http://dx.doi.org/10.1111/cge.12370] [PMID: 24588254]
[37]
Prasher B, Gibson G, Mukerji M. Genomic insights into ayurvedic and western approaches to personalized medicine. J Genet 2016; 95(1): 209-28.
[http://dx.doi.org/10.1007/s12041-015-0607-9] [PMID: 27019453]
[38]
Pandey S, Chaudhary AK. Advancement in Sandhanakalpana and role of biotechnology: need of research for diabetic patients. Int J Green Pharm 2018; 12 (Suppl. 1): S1-8.
[39]
Rastogi S, Kaphle K. Sustainable traditional medicine: taking the inspirations from ancient veterinary science. Evid Based Complement Alternat Med 2011; 2011151435
[http://dx.doi.org/10.1093/ecam/nen071] [PMID: 18980947]
[40]
Fakheri B, Rahimi M, Tavassoli A, et al. Application of biotechnology in production of medicinal plants. Am-Eurasian J Agric Environ Sci 2011; 11(3): 439-44.
[41]
Phillips T. Genetically modified organisms (GMOs): transgenic crops and recombinant DNA technology. New Educator 2008; 1(1): 213.
[42]
Birch RG. Plant transformation: problems and strategies for practical application. Annu Rev Plant Physiol Plant Mol Biol 1997; 48: 297-326.
[http://dx.doi.org/10.1146/annurev.arplant.48.1.297] [PMID: 15012265]
[43]
Lemonnier N, Zhou GB, Prasher B, et al. Traditional knowledge-based medicine: are view of history, principles, and relevance in the present context of P4 systems medicine. Prog Prev Med (NY) 2017; 2(7): e0011.
[http://dx.doi.org/10.1097/pp9.0000000000000011]
[44]
Paranjpe P, Patki P, Patwardhan B. Ayurvedic treatment of obesity: a randomised double-blind, placebo-controlled clinical trial. J Ethnopharmacol 1990; 29(1): 1-11.
[http://dx.doi.org/10.1016/0378-8741(90)90092-8] [PMID: 2278549]

Rights & Permissions Print Cite
Article Metrics
1
© 2024 Bentham Science Publishers | Privacy Policy