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ISSN (Print): 1872-2105
ISSN (Online): 2212-4020

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Research Article

Effects of Coupled-/soluble-Copper, Generating from Copper-doped Titanium Dioxide Nanotubes on Cell Response

Author(s): Pengyu Gao, Xiao Luo, Benli Yin, Zhisha Jiao, JunJi Piao, Ansha Zhao and Ping Yang*

Volume 17, Issue 2, 2023

Published on: 12 April, 2022

Page: [150 - 158] Pages: 9

DOI: 10.2174/1872210516666220114120412

Price: $65

Abstract

Background: Endothelialization in vitro is a very common method for surface modification of cardiovascular materials. However, mature endothelial cells are not suitable because of the difficulty in obtaining and immunogenicity.

Methods: In this patent work, we determined the appropriate amount of copper by constructing a copper- loaded titanium dioxide nanotube array that can catalyze the release of nitric oxide, compared the effects of coupled-/soluble-copper on stem cells, and then induced stem cells to differentiate into endothelial cells.

Results: The results showed that it had a strong promotion effect on the differentiation of stem cells into endothelial cells, which might be used for endothelialization in vitro.

Conclusion: SEM and EDS results prove that a high content of copper ions are indeed doped onto the surface of nanotubes with small amounts of Cu release. The release of NO confirms that the release of several samples within a period of time is within the physiological concentration.

Keywords: Copper, nanotubes, nitric oxide, stem cell, cell response, cardiovascular.

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