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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Review Article

Natural Bridged Bicyclic Peptide Macrobiomolecules from Celosia argentea and Amanita phalloides

Author(s): Sunita Dahiya, Rajiv Dahiya*, Neeraj Kumar Fuloria, Rita Mourya, Saurabh Dahiya, Shivkanya Fuloria, Suresh Kumar, Jyoti Shrivastava, Renu Saharan, Suresh V. Chennupati and Jayvadan K. Patel

Volume 22, Issue 13, 2022

Published on: 24 February, 2022

Page: [1772 - 1788] Pages: 17

DOI: 10.2174/1389557522666220113122117

Price: $65

Abstract

Bridged peptide macrobicycles (BPMs) from natural resources belong to types of compounds that are not investigated fully in terms of their formation, pharmacological potential, and stereo- chemical properties. This division of biologically active congeners with multiple circular rings has merits over other varieties of peptide molecules. BPMs form one of the most hopeful grounds for the establishment of drugs because of their close resemblance and biocompatibility with proteins, and these bio-actives are debated as feasible, realistic tools in diverse biomedical applications. Despite huge potential, poor metabolic stability and cell permeability limit the therapeutic success of macrocyclic peptides. In this review, we have comprehensively explored major bicyclic peptides sourced from plants and mushrooms, including βs-leucyl-tryptophano-histidine bridged and tryptophanocysteine bridged peptide macrobicycles. The unique structural features, structure-activity relationship, synthetic routes, bioproperties, and therapeutic potential of the natural BPMs are also discussed.

Keywords: Bridged peptides, plant seeds, mushrooms, bicycles, peptide synthesis, tubulin polymerization inhibition.

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