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Anti-Infective Agents

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ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

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Mini-Review Article

Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases

Author(s): Marco M. Custodio, Jennifer Sparks and Timothy E. Long*

Volume 20, Issue 3, 2022

Published on: 27 April, 2022

Article ID: e040122199856 Pages: 12

DOI: 10.2174/2211352520666220104104747

Price: $65

Abstract

This article reviews preclinical and clinical studies on the repurposed use of disulfiram (Antabuse) as an antimicrobial agent. Preclinical research covered on the alcohol sobriety aid includes uses as an anti-MRSA agent, a carbapenamase inhibitor, antifungal drug for candidiasis, and treatment for parasitic diseases due to protozoa (e.g., giardiasis, leishmaniasis, malaria) and helminthes (e.g., schistosomiasis, trichuriasis). Past, current, and pending clinical studies on disulfiram as a post-Lyme disease syndrome (PTLDS) therapy, an HIV latency reversal agent, and intervention for COVID-19 infections are also reviewed..

Keywords: Disulfiram, antabuse, antimicrobial, MRSA, lyme disease, HIV, COVID.

Graphical Abstract

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