失眠样睡眠模式变化与认知功能障碍之间的关联：可能的机制和治疗策略

Title:The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

Volume: 18 Issue: 11

关键词: 失眠、睡眠结构、睡眠连续性、认知能力下降、阿尔茨海默病、轻度认知障碍。

摘要: The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased, with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more beneficial since there is no cure for AD. This review mainly focuses on the altered sleep patterns in insomnia, and summarizes potential pathways underlying the relationship between insomnia and cognitive impairment, aiming to establish certain sleep pattern changes as biomarkers for cognitive decline and explore potential therapeutic targets based on evidence from research advances.

Cite this article as:

The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy, Current Alzheimer Research 2021; 18 (11) . https://dx.doi.org/10.2174/1567205018666211207095048