The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

Title:The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy

Volume: 18 Issue: 11

Author(s): Kangzhi Chen, Yefan Lv, Xiaoyan Long, Weiping Liu and Jinxia Zhou*

Affiliation:

• Department of Neurology, Xiangya Hospital, Central South University, Changsha,China

Keywords: Insomnia, sleep architecture, sleep continuity, cognitive decline, Alzheimer's disease, mild cognitive impairment.

Abstract: The prevalence of sleep disorders and cognitive dysfunction has overwhelmingly increased, with insomnia and Alzheimer’s disease (AD) being the most common form. A multitude of studies have linked the alterations in sleep continuity or sleep architecture with cognitive impairment bilaterally, but the management of disrupted sleep patterns in preclinical AD could be more beneficial since there is no cure for AD. This review mainly focuses on the altered sleep patterns in insomnia, and summarizes potential pathways underlying the relationship between insomnia and cognitive impairment, aiming to establish certain sleep pattern changes as biomarkers for cognitive decline and explore potential therapeutic targets based on evidence from research advances.

Cite this article as:

Chen Kangzhi , Lv Yefan , Long Xiaoyan , Liu Weiping and Zhou Jinxia*, The Association between Insomnia-Like Sleep Pattern Changes and Cognitive Dysfunction: Possible Mechanism and Therapeutic Strategy, Current Alzheimer Research 2021; 18 (11) . https://dx.doi.org/10.2174/1567205018666211207095048