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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

A New Method for the Synthesis of N,N-Diethyl-m-Methylbenzamide from m-Toluic Acid and Diethylamine Using 1,1'-Carbonyl-di-(1,2,4-triazole) (CDT) as Coupling Agent

Author(s): Duc Thinh Pham, Van Thu Nguyen, Binh Duong Vu* and Dinh Chau Phan*

Volume 19, Issue 9, 2022

Published on: 14 January, 2022

Page: [766 - 769] Pages: 4

DOI: 10.2174/1570178618666211119121227

Price: $65

Abstract

A new, simple method for the synthesis of N,N-diethyl-m-methylbenzamide (DEET) from m-toluic acid and diethylamine using 1,1'-carbonyl-di-(1,2,4-triazole) (CDT) as a coupling agent has been performed. The basic principles of activated carbonyls have been explored with the ability to prepare new amides easily. All reaction by-products are water-soluble as well as removed by filtration, the reaction could be purified easily in an aqueous solution by liquid-liquid extraction, and the product DEET was high purity. This experimental efficiency is about 94-95%, purity (HPLC): 97-98%.

Keywords: m-toluic acid, N, N-diethyl-m-toluamide, coupling agent, insect repellent, protect, synthesis.

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