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Review Article

小分子作为LIM激酶抑制剂

卷 29, 期 17, 2022

发表于: 18 January, 2022

页: [2995 - 3027] 页: 33

弟呕挨: 10.2174/0929867328666211026120335

价格: $65

摘要

LIMK1和LIMK2参与细胞功能的调节，这取决于肌动蛋白细胞骨架的动力学。LIM激酶的失调与疾病有关，例如肿瘤进展和转移，病毒感染和眼部疾病。受此启发，已经进行了大量研究，以发现能够有效和选择性地抑制LIM激酶的小有机分子。本综述报道了LIM激酶抑制剂有机小分子的综合调查，以及SAR研究结果，以及这些抑制剂的合成。

关键词: 细胞骨架，噻唑，噻吩并吡啶衍生物，噻吩并嘧啶，合成，LIM激酶。

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