Adenosine Dysfunction in Epilepsy and Associated Comorbidities

doi:10.2174/1389450122666210928145258
摘要

癫痫是一种复杂的神经系统综合症，具有主要症状和各种合并症，影响着全球超过 7000 万人。癫痫相关的合并症，包括认知障碍和精神障碍，会阻碍癫痫患者的治疗，给患者和社会带来沉重的负担。腺苷在大脑中具有抗癫痫和抗惊厥功能。多项研究表明，通过腺苷受体依赖性和非依赖性机制，腺苷可以影响癫痫及其相关合并症的发展和进展（癫痫发生）。作为腺苷清除的关键酶，腺苷激酶 (ADK) 不仅可以通过加速腺苷清除，还可以通过转甲基化途径增加整体 DNA 甲基化，从而加剧癫痫发作。因此，癫痫的腺苷增强疗法在抑制癫痫发作和预防其整体进展方面具有双重功能。这篇评论有三个主要目的。首先，我们讨论腺苷通路的不适应变化如何以受体依赖性和受体非依赖性方式影响癫痫的发展和进展。其次，我们强调了相关合并症对癫痫预后的重要影响，并探讨了腺苷在这些合并症中的作用。最后，我们强调了腺苷增强疗法在恢复癫痫大脑中正常腺苷信号传导方面的潜力。此类治疗可以有效改善对大多数抗癫痫药物（AEDs）耐药的患者的预后，从而为癫痫患者的治疗带来新的挑战和机遇。
关键词: 癫痫、腺苷、合并症、腺苷激酶、癫痫发生、腺苷增强治疗
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图形摘要

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DOI https://dx.doi.org/10.2174/1389450122666210928145258	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592
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