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Current Rheumatology Reviews

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ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

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Research Article

Is Fibromyalgia Associated with Borrelia-specific T Lymphocytes?

Author(s): Basant K. Puri*, Gary S. Lee and Armin Schwarzbach

Volume 18, Issue 2, 2022

Published on: 24 September, 2021

Page: [157 - 159] Pages: 3

DOI: 10.2174/1573397117666210924152636

Price: $65

Abstract

Background: Although fibromyalgia is a common cause of chronic musculoskeletal pain, its aetiology and pathophysiology are uncertain. It has recently been suggested that fibromyalgia symptomatology represents a T lymphocyte-mediated immune response to pathogens, which are known risk factors for autoimmune diseases. One major suggested candidate pathogen is the bacterial genus Borrelia. However, to date, this hypothesis has not been tested.

Objective: The aim was to carry out the first test of this hypothesis by comparing Borrelia-specific T lymphocyte reactivity in fibromyalgia patients and matched controls.

Methods: The enzyme-linked immunospot assay was used to detect T-lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen), outer surface protein (Osp) A from Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, native OspC plus decorin binding protein A recombinant and lymphocyte function antigen-1 (shared epitope) in 27 patients who fulfilled the revised diagnostic criteria for fibromyalgia of the American College of Rheumatology and in 26 control subjects. The assays were carried out blind to the group status of the participants.

Results: The two groups did not differ by age, sex or ethnicity. They did not differ significantly in respect of T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) (p = 0.847), Osp mix (p = 0.709) or lymphocyte function antigen-1 (p = 0.367).

Conclusion: This novel controlled study provides no evidence of an association between fibromyalgia and Borrelia-specific T lymphocytes.

Keywords: Fibromyalgia, T lymphocytes, Borrelia, immune response, autoimmune disease, enzyme-linked immunospot assay.

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[1]
Goldenberg DL. Do infections trigger fibromyalgia? Arthritis Rheum 1993; 36(11): 1489-92.
[http://dx.doi.org/10.1002/art.1780361102] [PMID: 8240426]
[2]
Banfi G, Diani M, Pigatto PD, Reali E. T cell subpopulations in the physiopathology of fibromyalgia: Evidence and perspectives. Int J Mol Sci 2020; 21(4): 21.
[http://dx.doi.org/10.3390/ijms21041186] [PMID: 32054062]
[3]
Ryabkova VA, Churilov LP, Shoenfeld Y. Neuroimmunology: What role for autoimmunity, neuroinflammation, and small fiber neuropathy in fibromyalgia, chronic fatigue syndrome, and adverse events after human papillomavirus vaccination? Int J Mol Sci 2019; 20(20): 20.
[http://dx.doi.org/10.3390/ijms20205164] [PMID: 31635218]
[4]
Buskila D, Atzeni F, Sarzi-Puttini P. Etiology of fibromyalgia: The possible role of infection and vaccination. Autoimmun Rev 2008; 8(1): 41-3.
[http://dx.doi.org/10.1016/j.autrev.2008.07.023] [PMID: 18706528]
[5]
Wolfe F, Clauw DJ, Fitzcharles M-A, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010; 62(5): 600-10.
[http://dx.doi.org/10.1002/acr.20140] [PMID: 20461783]
[6]
R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing 2017. Available from: https://www.eea.europa.eu/data-and-maps/indicators/ oxygen-consuming-substances-in-rivers/r-development-core- team-2006.
[7]
JASP (Version 0131). University of Amsterdam 2020.
[8]
Wormser GP, Weitzner E, McKenna D, et al. Brief report: Long-term assessment of fibromyalgia in patients with culture-confirmed Lyme disease. Arthritis Rheumatol 2015; 67(3): 837-9.
[http://dx.doi.org/10.1002/art.38972] [PMID: 25470117]
[9]
Boomershine CS. Fibromyalgia: The prototypical central sensitivity syndrome. Curr Rheumatol Rev 2015; 11(2): 131-45.
[http://dx.doi.org/10.2174/1573397111666150619095007] [PMID: 26088213]
[10]
Hsu VM, Patella SJ, Sigal LH. “Chronic Lyme disease” as the incorrect diagnosis in patients with fibromyalgia. Arthritis Rheum 1993; 36(11): 1493-500.
[http://dx.doi.org/10.1002/art.1780361103] [PMID: 8240427]

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