Generic placeholder image

Current Chinese Science

Editor-in-Chief

ISSN (Print): 2210-2981
ISSN (Online): 2210-2914

Review Article Section: Food Science

Chemical Constituents of Functional Food Amomum villosum to Combat Human Diseases

Author(s): Yawen Zeng*, Muhammad Kazim Ali, Wei He, Lin Deng, Xiaomeng Yang, Xia Li, Xiaoying Pu and Jiazhen Yang*

Volume 2, Issue 1, 2022

Published on: 23 September, 2021

Page: [57 - 67] Pages: 11

DOI: 10.2174/2210298101666210923124548

Price: $65

Abstract

Background: Amomum villosum is an important medicinal and edible plant owing to its valuable compositions of volatile and non-volatile compounds.

Objective: The study was conducted to reveal the chemical constituents and medicinal values of A. villosum against various diseases.

Methods: A critical and comprehensive data mining from 2004 to 2021 was performed based on CNKI, PubMed, and Google.

Results: 120 Compounds have been reported collectively in seeds, peels, and rhizomes of A. villosum, 10 compounds were common however the content of bornyl acetate was maximum in seeds and peels. Similarly, Amomi fructus of China and Vietnam showed 59 different types of volatile compounds while 13 were common, the round large black fruits (1.56% bornyl acetate and 4.05% volatile oil) and long small red fruits type (1.64% bornyl acetate and 3.04% volatile oil) from China showed good quality and high medicinal values. In addition, Amomi fructus manifested 30-40 kinds of nonvolatile compounds, i.e., phenolic, polysaccharides, saponins, flavonoid, vanillic acid, catechin, epicatechin, polydatin, isoquercitrin, quercitrin, glycosides, inorganic and organic acids.

Conclusion: A. villosum is widely used as anti-inflammatory, gastrointestinal protection, antiobesity, anticancer, antioxidant, analgesic, bacteriostasis, antidiabetic and anti-COVID-19, etc. So, it is manifested that the fruit, flowers, roots, stems, and leaves of A. villosum can be used as a medicine, especially fruit (Amomi fructus=Sharen), as the best functional food for the COVID-19 treatment and gastrointestinal protection as well as prevention of other diseases.

Keywords: Fructus amomi, functional foods, habitats quality, volatile oils, nonvolatile components, Amomum villosum, human diseases.

Graphical Abstract

[1]
Chinese Pharmacopoeia Commission. Chinese pharmacopoeia.China Medical Science Press: Beijing, China , 2015. 1: 191-3.
[2]
Cui, Y.; Chen, X.; Nie, L.; Sun, W.; Hu, H.; Lin, Y.; Li, H.; Zheng, X.; Song, J.; Yao, H. Comparison and phylogenetic analysis of chloroplast genomes of three medicinal and edible Amomum species. Int. J. Mol. Sci., 2019, 20(16), 4040.
[http://dx.doi.org/10.3390/ijms20164040] [PMID: 31430862]
[3]
Doh, E.J.; Kim, J.H.; Lee, G. Identification and monitoring of Amomi Fructus and its adulterants based on DNA barcoding analysis and designed DNA markers. Molecules, 2019, 24(22), 4193.
[http://dx.doi.org/10.3390/molecules24224193] [PMID: 31752298]
[4]
Liu, Y.B.; Liang, Z.H.; Li, P.; Xia, Y.; Wu, Q.J.; Du, B. Preparation of flavonoid-rich Amomum villosum Lour. fermented beverage with by Bacillus sp. DU-106. Farm Products Processing 2019, (7), 8-11.
[5]
Gong, L.; Ye, Y.S.; Wu, J.; Wu, M.L.; Su, H.; Huang, Z.H. Global production area prediction of Amomum villosum Lour through GMPGIS. World Chin. Med., 2017, 12(5), 989-995.
[6]
Yao, Y.; Mi, W.; Cao, G.; Yang, R.; Chen, H.; Liu, Y.; Zou, H.; Yan, Y. The absorption characteristics of nonvolatile components in a water extraction from amomi fructusas determined by in situ single-pass intestinal perfusion and high-performance liquid chromatography. Front. Pharmacol., 2020, 11, 711.
[http://dx.doi.org/10.3389/fphar.2020.00711] [PMID: 32581779]
[7]
Ao, H.; Wang, J.; Chen, L.; Li, S.; Dai, C. Comparison of volatile oil between the fruits of Amomum villosum Lour. and Amomum villosum Lour. var. xanthioides T. L.Wu et Senjen based on GC-MS and chemometric techniques. Molecules, 2019, 24(9), 1663.
[http://dx.doi.org/10.3390/molecules24091663] [PMID: 31035329]
[8]
Yang, J.; Huang, W.; Li, Q.L.; Ye, G.S.; Ou, H.H.; Li, Y.L. Preparation of sugar-free chewing gum with gluten-based tangerine peel and fructus amomi. Food Eng., 2020, (2), 14-19.
[9]
Li, L.L.; Tian, W.C.; Liu, Y.; Li, Y.J.; Cao, X.X.; Zhang, W. Research progress on chemical constituents and pharmacological effects of Amomum villosum. Progress Mod. Biomed, 2018, 18(22), 4390-4396.
[10]
Suo, S.; Lai, Y.; Li, M.; Song, Q.; Cai, J.; Zhao, J.; Yang, Q.; Ung, C.O.L.; Hu, H. Phytochemicals, pharmacology, clinical application, patents, and products of Amomi fructus. Food Chem. Toxicol., 2018, 119, 31-36.
[http://dx.doi.org/10.1016/j.fct.2018.05.051] [PMID: 29802946]
[11]
Xie, Z.H.; Cai, X.Y.; Wang, Y.Q.; Wang, J.M. The importance of landscape managements on development of chemical components of Amomum villosum Lour. cultivated in Yunnan Province: A management perspective. Huanjing Kunchong Xuebao, 2020, 42(3), 695-700.
[12]
Lv, H.; Pian, R.; Xing, Y.; Zhou, W.; Yang, F.; Chen, X.; Zhang, Q. Effects of citric acid on fermentation characteristics and bacterial diversity of Amomum villosum silage. Bioresour. Technol., 2020, 307123290
[http://dx.doi.org/10.1016/j.biortech.2020.123290] [PMID: 32265091]
[13]
Huang, L.; Fu, X.Q.; Xiao, J.; Wang, R.; Zhao, R.H.; Bao, N.M. GC-MS analysis of volatile components in different parts of Amomum villosum L. J. Chengdu Univ. Trad. Chin. Med., 2020, 43(2), 42-46.
[14]
Chen, L.; Ao, H.; Ye, Q.; Li, H.X. Chemical constituents analysis of volatile oil from different parts of the fruit of Amomum villosum by GC-MS. Chin. J. Exp. Trad. Med. Formul, 2014, 20(14), 80-83.
[15]
Xing, X.F.; Li, X.Y.; Chen, F.L.; Xu, W.X. Study on chemical constituents of essential oil from fruits and leaves of Amomum villosum Lour. by GC-MS. Trad. Chin. Drug Res. Clin. Pharm., 2012, 23(6), 667-669.
[16]
Huang, L.; Fu, X.Q.; Zhao, R.H.; Bao, N.M. GC-MS analysis on the content of borneol acetate and volatile oil of Amomum villosum different matures. Zhong Yao Cai, 2020, 43(5), 1101-1106.
[17]
Huang, L.; Fu, X.Q.; Zhao, R.H.; Bao, N.M. Study on the chemical composition of seed shell of Amomum villosum. Yunnan J. Trad. Chin. Med. Mater. Med., 2020, 41(5), 77-79.
[18]
Zhang, T.; Yang, P.; Guo, Y.W.; Zhao, R.H.; Peng, Y. Variation of floral scent composition of Amomum villosum before and after pollination and its ecological significance. Shengtaixue Zazhi, 2018, 37(12), 3640-3646.
[19]
Han, Z.Q.; Zhang, H.J.; Guo, S.Y.; Lu, Y.L.; Li, G.P.; Shi, H.L. Analysis for volatile compounds of two plants in Amomum by GC-MS. Food Res. Develop, 2013, 34(20), 79-83.
[20]
Hou, J.N.; Guo, C.; Deng, X.M.; Li, G.; Lv, G.Q. Analysis of volatile components in fructus amomi from different habitats by headspace solid phase micro-extraction gas chromatography-mass spectrometry. J. Guangzhou Univ. Trad. Chin. Med., 2020, 37(7), 1366-1371.
[21]
Yang, C.X. A comparative study on the chemical composition and main pharmacodynamics of Amomum villosum Lour. planted in Yunnan province and Fructus Amomi planted in Myanmar.. Master Thesis, Yunnan University of Traditional Chinese Medicine, Kunming. 2017.
[22]
Zhao, H.N.; Huang, L.F.; Liu, X.L.; Cao, Q.X.; Ji, S.G. Study on quality variation of Amomum villosum Lour. from different producing areas. Guangdong Yaoxueyuan Xuebao, 2016, 32(2), 176-180.
[23]
Qiu, J.J.; Luo, D.H.; Liu, Y.; Liu, J.M. Quality evaluation of different varieties of Amomum villosum Lour. from geo-authentic habitat. Trad. Chin. Drug Res. Clin. Pharm, 2019, 30(2), 221-226.
[24]
Wang, Y.Q.; Yang, C.Y.; Luo, C.B.; Peng, J.M.; Li, G.; Li, S.; Zhang, L.X. Analysis of morphological characteristics and medicinal composition of fruits of Amomum villosum Lour. in different producing areas. Anhui Nongye Kexue, 2019, 47(19), 186-189.
[25]
Yin, H.; Jiang, N.; Guo, C.; Gao, J.M. A new bergamotane sesquiterpenoid from the rhizomes of Amomum villosum var. xanthioides. Nat. Prod. Res., 2019, 82(11), 2963-2971.
[http://dx.doi.org/10.1080/14786419.2019.1633649] [PMID: 31274017]
[26]
Yin, H.; Dan, W.J.; Fan, B.Y.; Guo, C.; Wu, K.; Li, D.; Xian, K.F.; Pescitelli, G.; Gao, J.M. Anti-inflammatory and α-glucosidase inhibitory activities of labdane and norlabdane diterpenoids from the rhizomes of Amomum villosum. J. Nat. Prod., 2019, 82(11), 2963-2971.
[http://dx.doi.org/10.1021/acs.jnatprod.9b00283] [PMID: 31710213]
[27]
Zhou, H.Q.; Liu, Y.; Yan, Y.H.; Li, J.; Yang, X.Y. Comparison of contents of total flavonoids residue in various medicinal parts of amomi fructus. China Arch. Trad. Chin. Med, 2013, 31(2), 376-378.
[28]
Li, Q.X.; Gao, Y.E.; Qu, K.X.; Liu, J.Y.; Huang, B.Z.; Wang, A.K.; Wang, X.; Yang, G.R. Evaluation on feeding value of stems and leaves in fructus amomi. Anim. Husb. Veter. Med., 2016, 48(10), 61-63.
[29]
Huang, Q.; Duan, Z.; Yang, J.; Ma, X.; Zhan, R.; Xu, H.; Chen, W. SNP typing for germplasm identification of Amomum villosum Lour. Based on DNA barcoding markers. PLoS One, 2014, 9(12)e114940
[http://dx.doi.org/10.1371/journal.pone.0114940] [PMID: 25531885]
[30]
Ma, M.; Lu, B. The complete chloroplast genome sequence of Amomum villosum Lour. Mitochondrial DNA B Resour., 2020, 5(1), 1042-1043.
[http://dx.doi.org/10.1080/23802359.2020.1721358] [PMID: 33366865]
[31]
Han, Y.W.; Zhang, W.X.; Zeng, P.; Hu, H.; Wang, Y.T.; Cai, J. The complete chloroplast genome of the essential medicinal herb, Amomum villosum (Zingiberaceae). Mitochondr. DNA Part B, 2019, 4(1), 1798-1799.
[32]
Yang, E.Z.; Lu, Y.S.; Wu, Q.H.; Wang, F. Cloning and expression profiles analysis of PMK gene in Amomum villosum Lour. J. Jinan Univ. (Nat. Sc. Med. Ed.), , 2015. 36(2), 95-101.
[33]
Wang, H.; Li, M.; Ma, D.M.; Ye, P.; Zhan, R.T.; Yang, J.F. Cloning and activity analysis of AvTPS1 promoter of terpene synthase from Amomum villousm. Chin. Tradit. Herbal Drugs, 2019, 50(9), 2181-2187.
[34]
Li, M.; Wang, H.; Zhao, H.Y.; Huang, Y.P.; Yang, J.F. Gene cloning, analysis and prokaryotic expression of WRKY40 from Amomum villosum Lour. Mol. Plant Breed., 2019, 17(6), 1843-1852.
[35]
Deng, K.; Yang, J.F.; Wang, T.; Wang, H.; Wang, H.; Su, J.F.; Zhan, R.T. Mining of genes involved in terpenoid synthases based on transcriptome analysis and cloning of monoterpene synthase from Amomum villosum Lour. J. Guangzhou Univ.Trad. Chin. Med, 2016, 33(3), 395-403.
[36]
He, X.Y.; Yang, J.F.; Zhang, M.L.; Zhong, Z.M.; Yu, A.M.; Xu, H.; Zhan, R.T.; Chen, W.W. Changes of salicylic acid content and expression of salicylic acid signal transduction pathway genes during fruit development of Amomum villosum Lour. J. Guangzhou Univ. Trad. Chin. Med., 2016, 33(3), 404-410.
[37]
Wang, H.; Yang, J.F.; Deng, K.; He, X.Y.; Zhan, R.T.; Tang, L. Methyl jasmonate affects metabolism and gene transcription of volatile terpenoids from Amomum villosum Lour.World Sci. Technol.-Modern. Trad. Chin. Med., 2014, 16(7), 1528-1536.
[38]
Chen, Z.; Ni, W.; Yang, C.; Zhang, T.; Lu, S.; Zhao, R.; Mao, X.; Yu, J. Therapeutic effect of Amomum villosum on inflammatory bowel disease in rats. Front. Pharmacol., 2018, 9, 639.
[http://dx.doi.org/10.3389/fphar.2018.00639] [PMID: 29973876]
[39]
Lu, C.L.; Zhao, H.Y.; Jiang, J.G. Evaluation of multi-activities of 14 edible species from Zingiberaceae. Int. J. Food Sci. Nutr., 2013, 64(1), 28-35.
[http://dx.doi.org/10.3109/09637486.2012.694852] [PMID: 22716965]
[40]
Ke, B.; Shi, L. Exploring clinical efficacy of Fructus Amomi. China J. Trad. Chin. Med. Pharm, 2012, 27(1), 128-129.
[41]
Wu, X.; Li, X.; Xiao, F.; Zhang, Z.; Xu, Z.; Wang, H. [Studies on the analgesic and anti-inflammatory effect of bornyl acetate in volatile oil from Amomum villosum.]. Zhong Yao Cai, 2004. 27(6), 438-439.
[PMID: 15524301]
[42]
Zeng, Y.W.; Du, J.; Pu, X.Y.; Yang, X.M.; Li, X.; Yang, J.Z. Remarkable efficacy of COVID-19 treatment by traditional Chinese medicine. Science, 2020, 367(6481)
[43]
Wang, C.; Ming, H.; Jia, W.; Su, W.; Zhan, L.R.; Luo, D.; Yang, J.Y. [Analysis of medication regularity and pharmacodynamic characteristics of traditional Chinese medicine treatment in 444 severe cases of COVID-19 Zhongguo Zhongyao Zazhi, 2020, 45(13), 3007-3012.
[PMID: 32726005]
[44]
Liu, J.W.; Wang, X.X.; Hu, L.X.; Zhang, S.H.; Hu, S.; Wang, Q.; Zhou, Z.X. Analysis and monitoring of the treatment prescription of COVID-19 based on data mining. Lishizhen Med. Materia Med. Res, 2020, 31(3), 704-706.
[45]
Biswas, S.K. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxid. Med. Cell. Longev., 2016, 20165698931
[http://dx.doi.org/10.1155/2016/5698931]
[46]
Tran, Q.T.N.; Wong, W.S.F.; Chai, C.L.L. Labdane diterpenoids as potential anti-inflammatory agents. Pharmacol. Res., 2017, 124, 43-63.
[http://dx.doi.org/10.1016/j.phrs.2017.07.019] [PMID: 28751221]
[47]
Lim, D.W.; Choi, H.J.; Park, S.D.; Kim, H.; Yu, G.R.; Kim, J.E.; Park, W.H. Activation of the Nrf2/HO-1 pathway by Amomum villosum extract suppresses LPS-induced oxidative stress in vitro and ex vivo. Evid. Based Complement. Alternat. Med., 2020, 20202837853
[http://dx.doi.org/10.1155/2020/2837853] [PMID: 32454852]
[48]
Lu, S.; Zhang, T.; Gu, W.; Yang, X.X.; Lu, J.M.; Zhao, R.H.; Yu, J. J. Volatile oil of Amomum villosum inhibits non- alcoholic fatty liver disease via the gut-liver axis. Biomed Res. Int., 2018, 2018.
[49]
Zhang, T.; Lu, S.H.; Bi, Q.; Liang, L.; Wang, Y.F.; Yang, X.X.; Gu, W.; Yu, J. Volatile oil from Amomi Fructus attenuates 5-fluorouracil-induced intestinal mucositis. Front. Pharmacol., 2017, 8, 786.
[http://dx.doi.org/10.3389/fphar.2017.00786] [PMID: 29170638]
[50]
Zhang, T.; Lu, S.H.; Yang, X.X.; Gu, W.; Bi, Q.; Liang, L.; Yu, J. Protective effect of Amomi Fructus water extraction on intestinal mucositis induced by 5-FU. Chin. J. Mod. Appl. Pharm., 2019, 36(3), 286-291.
[51]
Lee, Y.G.; Park, J.H.; Jeon, E.S.; Kim, J.H.; Lim, B.K. Fructus Amomi cardamomi extract inhibits coxsackievirus-B3 induced myocarditis in a murine myocarditis model. J. Microbiol. Biotechnol., 2016, 26(11), 2012-2018.
[http://dx.doi.org/10.4014/jmb.1605.05056] [PMID: 27558433]
[52]
Huang, G.D.; Huang, Y.H.; Huang, D.F.; Xiao, M.Z.; Tang, L.J. Mechanism of volatile oil in Amomum villosumon on anti-gastric ulcer. Chin. Trad. Patent Med, 2009, 31(10), 1617-1618.
[53]
Cao, Y.; Gong, H.J.; Hang, G.; Wang, Y.D.; Zhang, Y. Clinical study on Amomum villosum’s promotion of gastrointestinal function recovery after gastric operation. Mod.J.Integr. Trad. Chin. West. Med., 2019, 28(1), 19-23.
[54]
Xie, R.S.; Li, X.Y.; Zeng, G.; Liang, C.Y.; Zhang, L.W. Clinical observation of Amomum villosum extract in treating functional dyspepsia with the syndrome of insufficiency of spleen-yang. J. New Chin. Med, 2016, 48(8), 65-67.
[55]
Chen, M.Z.; Zhong, X.M.; Chen, X.S.; Chen, Y.; Ao, F.F. Development compound functional beverage of green plum and Amomum villosum Lour. Anhui Nongye Kexue, 2019, 47(20), 176-178.
[56]
Kim, H.R.; Kwon, Y.K.; Choi, B.K.; Jung, H.J.; Baek, D.G. Effect of mixture of atractylodes macrocephala and Amomum villosum extracts on body weight and lipid metabolism in high fat diet-induced obesity model. J. Physiol. Pathol. Korean Med, 2020, 34(2), 75-80.
[http://dx.doi.org/10.15188/kjopp.2020.04.34.2.75]
[57]
Kim, H.R.; Kwon, Y.K.; Choi, B.K.; Baek, D.G. Inhibitiory effects of mixture of atractylodes macrocephala and Amomum villosum extracts on adipocyte differentiation in OP9 cells. J. Physiol. Pathol. Korean Med, 2020, 34(1), 24-29.
[http://dx.doi.org/10.15188/kjopp.2020.02.34.1.24]
[58]
Gao, L.L.; Wang, Q.; Zhang, J.W.; Huang, R.Q.; Zhang, X.W. Study on purification and antibacterial and antitumor activity of flavonoids from Amomum villosum Lour and Alpinia oxyphylla Miq. Shipin Anquan Zhiliang Jiance Xuebao, 2019, 10(14), 4459-4466.
[59]
Zhao, G.; Li, J.; Yang, J. Inhibitory effects of fructus amomi, polygonum cuspidatum sieb and cinamomi ramulus on the proliferation of MCF-7 breast cancer cells. Chin. Med. Equip, 2016, 13(6), 94-98.
[60]
Zhong, X.M.; Chen, M.Z.; Pang, J.M. Antioxidant and antibacterial activities of the crude extract of total flavonoids from Amomum villosum Lour. Shipin Anquan Zhiliang Jiance Xuebao, 2018, 9(13), 3335-3339.
[61]
Yan, Y.; Li, X.; Wan, M.; Chen, J.; Li, S.; Cao, M.; Zhang, D. Effect of extraction methods on property and bioactivity of water-soluble polysaccharides from Amomum villosum. Carbohydr. Polym., 2015, 117, 632-635.
[http://dx.doi.org/10.1016/j.carbpol.2014.09.070] [PMID: 25498681]
[62]
Li, S.J.; Zhang, D.Y.; Yan, Y.J.; Cao, M. Isolation, purification and antioxidant activity of polysaccharide from Amomum villosum. Nat. Prod. Res. Develop, 2014, 26(12), 2037-2040.
[63]
You, X.M.; Li, Y.Z.; Liao, Y.Z.; Li, T.; Hong, Y.; Zeng, D.; Zhang, Y.F. Antioxidant activity of the extracts from Amomum villosum roots and leaves. Food Sci. Tech, 2012, (2), 226-228., 2012.
[64]
Cao, G.H.; Zhang, X.; Wang, X.F.; Xiong, J.; Wang, J.; Li, X.G.; Xiao, J.B.; Zhao, R.H.; He, S. Comparison of bacteriostatic effects of different extracts from fructus amomi and its salt- processed products. Sci. Technol. Food Industry, 2020, 41(6), 82-87.
[65]
Cao, G.H.; Zhang, X.; Chen, Y.Y.; Yue, J.; Li, Z.D.; Zhao, Z.Y.; Zhao, R.H.; He, S. Comparison of bacter-iostatic effect of ethanol extract from the leaves and stems of Amomum villosum. Zhongchengyao, 2020, 42(7), 1914-1917.
[66]
Tang, C.; Chen, J.; Zhou, Y.; Ding, P.; He, G.; Zhang, L.; Zhao, Z.; Yang, D. Exploring antimicrobial mechanism of essential oil of Amomum villosum Lour through metabolomics based on gas chromatography-mass spectrometry in methicillin-resistant Staphylococcus aureus. Microbiol. Res., 2021, 242126608
[http://dx.doi.org/10.1016/j.micres.2020.126608] [PMID: 33068829]
[67]
Li, S.M.; Ye, Q.; Ao, H. Relationship between the GC-MS fingerprints of essential oil from Amomi Fructus and its analgesia effect. Chin. Trad. Patent Med., 2016, 38(2), 346-350.
[68]
Wu, X.; Xiao, F.; Zhang, Z.; Li, X.; Xu, Z. Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from amomum villosum.]. Zhong Yao Cai, 2005, 28(6), 505-507.
[PMID: 16209271]
[69]
Kim, H.R.; Paulrayer, A.; Kwon, Y.G.; Ryu, D.G.; Baek, D.G.; Geum, J.H.; Lee, J.H.; Lee, G.S.; Kwon, K.B. Acute effects of Amomum villosum Lour. fruit extract on postprandial glycemia and insulin secretion: A single-blind, placebo-controlled, crossover study in healthy subjects. Saudi J. Biol. Sci., 2020, 27(11), 2968-2971.
[http://dx.doi.org/10.1016/j.sjbs.2020.07.017] [PMID: 33100854]
[70]
Zhao, R.J.; Zhao, Z.L.; Jin, M.H.; Kim, S.C.; Yang, C.H. Hypoglycemic effects of extract of Amomum Xanthoides on experimental diabetes in rats. J. Medical Science Yanbian Univ., 2006, 29(2), 97-99.
[71]
Zeng, Y.W.; Pu, X.Y.; Du, J.; Yang, X.M.; Li, X.; Mandal, M.S.N.; Yang, T.; Yang, J.Z. Molecular mechanism of functional ingredients in barley to combat human chronic diseases. Oxid. Med. Cell. Longev., 2020, 20203836172
[http://dx.doi.org/10.1155/2020/3836172]
[72]
Chen, Y. Pharmacological action and market price trend of Amomum villosum in China in 2020, Yunnan is the main producing area of Amomum villosum. 2020. Available from: https://www.huaon.com/channel/trend/605793.html(Accessed April 24,2020)

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy