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Review Article

肽聚糖脱乙酰酶在细菌细胞壁重塑和发病机制中的作用

卷 29, 期 7, 2022

发表于: 10 January, 2022

页: [1293 - 1312] 页: 20

弟呕挨: 10.2174/0929867328666210915113723

价格: $65

摘要

细菌细胞壁肽聚糖（PG）是一种动态结构，在细菌分裂和生长过程中不断合成、重塑和降解。 合成后修饰在 PG 裂解和重塑生长和孢子形成过程中调节内源性自溶的作用，但它们也是病原菌用来逃避宿主先天免疫系统的一种机制。 聚糖骨架的修饰仅限于 GlcNAc 或 MurNAc 残基的 C-2 胺和 C-6 羟基部分。 本文回顾了肽聚糖去乙酰化酶（不同的 PG GlcNAc 和 MurNAc 去乙酰化酶）的功能作用和特性，以及通过遗传学研究和生化表征阐明其作用机制、3D 结构、底物特异性和生物学功能的最新进展。 由于它们是病原菌中的毒力因子，因此肽聚糖脱乙酰酶是设计新型抗菌剂的潜在目标。

关键词: 肽聚糖脱乙酰酶、细胞壁、发病机制、N-乙酰氨基葡萄糖、N-乙酰胞壁、特异性、X 射线结构、抗菌靶点

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