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Research Article

计算分析阐明清肺排毒汤阻断 COVID-19 患者从轻度到重度转变的机制

卷 22, 期 3, 2022

发表于: 07 September, 2021

页: [277 - 289] 页: 13

弟呕挨: 10.2174/1566523221666210907162005

价格: $65

摘要

背景：SARS-CoV-2 的流行使 COVID-19 对全世界的人类健康构成了严重威胁。 SARS-CoV-2 的严重感染通常伴随着更高的死亡率。尽管清肺排毒汤（QFPDD）已被证明可有效阻断 COVID-19 患者从轻度到重度的转变，但其作用机制仍不清楚。 目的：本研究旨在探讨 QFPDD 在阻断 COVID-19 患者从轻症期向重症期转变中的作用机制。 材料与方法：在筛选活性成分的过程中，口服生物利用度（OB）和药物相似性（DL）是关键指标，有助于筛选出关键化合物。因此，我们以OB≥30%和DL≥0.18为标准，以21种药材为关键词，在《中药系统药理学》（TCMSP，https://tcmspw.com/）中检索了QFPDD的有效成分。结果：我们采用生物信息学方法从QFPDD中筛选出6种关键成分，即槲皮素、木犀草素、黄连素、常春藤素、紫罗兰酮和山柰酚，它们可以抑制高表达基因（即CXCR4、ICAM1、CXCL8、CXCL10、IL6、IL2、 CCL2、IL1B、IL4、IFNG) 用于重症 COVID-19 患者。通过KEGG富集分析，我们发现了7条通路，分别是TNF信号通路、IL-17信号通路、Toll样受体信号通路、NFkappa B信号通路、HIF-1信号通路、JAK-STAT信号通路和Th17细胞分化，通过 QFPDD 可以阻止 COVID-19 患者从轻度到重度阶段的转变。 结论：QFPDD通过抑制SARS-CoV-2的侵袭和复制、抗炎和免疫调节、修复机体损伤等机制可以预防COVID-19的恶化。这些结果将有助于 COVID-19 的预防和治疗。

关键词: SARS-CoV-2、COVID-19、网络药理学、蛋白质-蛋白质相互作用、KEGG 通路、分子对接

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