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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

Carpal Tunnel Syndrome in Diabetes Mellitus

Author(s): Nikolaos Papanas*, Iliana Stamatiou and Stella Papachristou

Volume 18, Issue 4, 2022

Published on: 06 January, 2022

Article ID: e010921196025 Pages: 4

DOI: 10.2174/1573399817666210901114610

Price: $65

Abstract

The aim of the present brief review was to discuss carpal tunnel syndrome (CTS) in diabetes mellitus (DM). Generally, CTS is more common in DM, especially in subjects with coexisting diabetic polyneuropathy (DPN) and/or long DM duration. There is no agreement if it is more frequent in type 1 or type 2 DM. The precise underlying mechanisms are not entirely clear but appear to involve hyperglycaemia-induced median nerve oedema, increased sensitivity to exogenous trauma and nerve myelin ischaemia and axonal degeneration. More recently, increased vascular endothelial growth factor (VEGF) and advanced glycation endproducts (AGEs) appear to also play an important role. Median nerve conduction study remains the cornerstone of CTS diagnosis in DM, being more sensitive than clinical examination. CTS can be treated medically or surgically. The latter appears now to be equally effective in subjects with vs. without DM in terms of recurrence rates and quality of life.

Keywords: Carpal tunnel syndrome, diabetes mellitus, diagnosis, median nerve, nerve conduction study, treatment.

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