Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Review Article

Herbal Drugs as Immune Booster Against Viral Infections

Author(s): Gyanendra Mohapatra, Biswa Mohan Sahoo*, Bimalendu Chowdhury, J. Sruti, Rabi Narayan Rana, Rajaram Das and Jasma Jena

Volume 18, Issue 2, 2022

Published on: 04 January, 2022

Page: [132 - 143] Pages: 12

DOI: 10.2174/1573401317666210816102404

Price: $65

Abstract

The immune system involves both active and passive immunization. The antibodies are developed against the antigens during active immunization and are permanently stored. But, in the case of passive immunization, the antibodies are exposed to the same antigens in every person who is already infected. In order to enhance the immune systems i.e. innate and adaptive immune responses, herbal plants are used as an immune booster. Some of the herbal plants have been proven clinically to enhance immunity that includes Morniga oleifera (Drumstick), Azadirachta indica (Neem), Ocimum sanctum (Tulsi), Withania somnifera (Aswagandha), Zingiber officinale (Ginger), Allium sativum (Garlic), Curcuma longa (Turmeric), Emblica officinalis (Amla) etc. Compared to synthetic drugs, herbal drugs have fewer side effects and stimulate the immune system to defend against various foreign pathogens. Even though herbal medicines are usually considered as safe and effective therapy, it is clinically proven that if a drug is effective, it would have some side effects. But, sometimes, the antioxidant property of herbal medicines is helpful in reducing the toxicities produced by any toxic substances or any drugs. This review aims to encourage the study of various herbal constituents and their role in the treatment of different types of viral infections.

Keywords: Antibody, antigen, herbal plants, immunity, immune booster, viral infections.

Graphical Abstract

[1]
Cassa Macedo A, Oliveira Vilela de Faria A, Ghezzi P. Boosting the immune system, from science to myth: analysis the infosphere with google. Front Med (Lausanne) 2019; 6: 165.
[http://dx.doi.org/10.3389/fmed.2019.00165] [PMID: 31403046]
[2]
Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect 2012; 45(3): 165-84.
[http://dx.doi.org/10.1016/j.jmii.2011.09.030] [PMID: 22154993]
[3]
Nagarsheth N, Wicha M, Zou W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nature Revi immunol 2017; 17(9): 559-72.
[http://dx.doi.org/10.1038/nri.2017.49]
[4]
Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azadirachta indica) oil. Int J Immunopharmacol 1992; 14(7): 1187-93.
[http://dx.doi.org/10.1016/0192-0561(92)90054-O] [PMID: 1452404]
[5]
Khodadadi S. Role of herbal medicine in boosting immune system. Immunopathol Persa 2015; 1(1): 1-2.
[6]
Dutt S. A review on immunomodulatory activity of some indigenous medical plants. Anc Sci Life 2013; 32(S2): 55.
[http://dx.doi.org/10.4103/0257-7941.123871]
[7]
Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009; 22(2): 240-73.
[http://dx.doi.org/10.1128/CMR.00046-08] [PMID: 19366914]
[8]
Sharma P, Kumar P, Sharma R, Gupta G, Chaudhary A. Immunomodulators: Role of medicinal plants in immune system. Natl J Physiol Pharm Pharmacol 2017; 7(6): 1.
[http://dx.doi.org/10.5455/njppp.2017.7.0203808032017]
[9]
Barik CS, Kanungo SK, Tripathy NK, Panda J, Sahoo BM. Evaluation of free radical scavenging activity of polyherbal formulations containing four different plant extracts. Der Pharmacia Lett 2016; 8(2): 496-501.
[10]
Shah NS, Ershler WB. Immune system Encyclopedia of gerontology. USA: Elsevier 2007; pp. 742-9.
[11]
Singh N, Tailang M, Mehta S. A Review on herbal plants as immunomodulators. Int J Pharm Sci Res 2016; 7(9): 3602-10.
[12]
Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol 2001; 78(2-3): 133-7.
[http://dx.doi.org/10.1016/S0378-8741(01)00326-9] [PMID: 11694357]
[13]
Petrunov B, Nenkov P, Shekerdjiisky R. The role of immunostimulants in immunotherapy and immunoprophylaxis. Biotechnol Biotechnol Equip 2007; 21(4): 454-62.
[http://dx.doi.org/10.1080/13102818.2007.10817494]
[14]
Shah A, Gunjal M, Juvekar A. Immunomostimulatory activity of aqueous extract of Azadirachta indica flowers on specific and non specific immune response. J Nat Rem 2009; 9(1): 35-42.
[15]
Babich O, Sukhikh S, Prosekov A, Asyakina L, Ivanova S. Medicinal plants to strengthen immunity during a pandemic. Pharmaceuticals (Basel) 2020; 13(10): 313-30.
[http://dx.doi.org/10.3390/ph13100313] [PMID: 33076514]
[16]
Alzohairy M. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med 2016.7382506
[17]
Bano N, Ahmed A, Tanveer M, Khan GM, Ansari MT. Pharmacological evaluation of Ocimum sanctum. J Bioequivalence Bioavailab 2017; 09(03): 387-92.
[18]
Jamshidi N, Cohen M. The clinical efficacy and safety of Tulsi in humans: A systematic review of the literature. Evid Based Complement Alternat Med 2017. PMC5376420
[http://dx.doi.org/10.1155/2017/9217567]
[19]
Panchal P, Parvez N. Phytochemical analysis of medicinal herb (Ocimum sanctum). Int J of Nanomat. Nanotechnol and Nanomed 2019; 5(2): 8-11.
[20]
Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 2010; 4(7): 95-105.
[http://dx.doi.org/10.4103/0973-7847.65323] [PMID: 22228948]
[21]
Gupta G, Rana A. Withania somnifera (Ashwagandha): A Review. Pharmacogn Rev 2007; 1(1): 129-36.
[22]
Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: A Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med 2011; 8(5): 208-13.
[http://dx.doi.org/10.4314/ajtcam.v8i5S.9] [PMID: 22754076]
[23]
Gupta SM, Shivaprasad H, Kharya M, Rana A. Immunomodulatory activity of the Ayurvedic formulation “Ashwagandha Churna”. Pharm Biol 2006; 44(4): 263-5.
[http://dx.doi.org/10.1080/13880200600713949]
[24]
Yamada K, Hung P, Park TK, Park PJ, Lim BO. A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi. J Ethnopharmacol 2011; 137(1): 231-5.
[http://dx.doi.org/10.1016/j.jep.2011.05.017] [PMID: 21619924]
[25]
Xiao C, Guan Q, Tan Y, Hou L, Xie W. Medical plants and immunological regulation. J Immunol Res 2018; 20189172096
[http://dx.doi.org/10.1155/2018/9172096] [PMID: 30009189]
[26]
Arreola R, Quintero-Fabián S, López-Roa RI, et al. Immunomodulation and anti-inflammatory effects of garlic compounds. J Immunol Res 2015; 2015401630
[http://dx.doi.org/10.1155/2015/401630] [PMID: 25961060]
[27]
Pranoto Y, Salokhe V, Rakshit S. Physical and antibacterial properties of alginate-based edible film incorporated with garlic oil. Food Res Int 2005; 38(3): 267-72.
[http://dx.doi.org/10.1016/j.foodres.2004.04.009]
[28]
Moutia M, Habti N, Badou A. In-vitro and in-vivo immunomodulatory activities of Allium sativum L. Evid Based Complement Alternat Med 2018; 2018: 1-10.
[29]
Schäfer G, Kaschula CH. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anticancer Agents Med Chem 2014; 14(2): 233-40.
[http://dx.doi.org/10.2174/18715206113136660370] [PMID: 24237225]
[30]
Singh R, Singh K. Zingiber officinale: A spice with multiple roles. Res J Life Sci Bioinf Pharmaceut and Chem Sci 2019; 5(2): 113-25.
[31]
Sahoo BM, Banik BK. Medicinal plants: Source for immunosuppressive agents. Immunol Curr Res 2018; 2: 1-5.
[32]
Singh P, Srivastava S, Singh V, Sharma P, Singh D. Ginger (Zingiber officinale): A novel herbal remedy. Int J Curr Microbiol Appl Sci 2018; 7(7): 4065-77.
[33]
Carrasco FR, Schmidt G, Romero AL, et al. Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses. J Pharm Pharmacol 2009; 61(7): 961-7.
[http://dx.doi.org/10.1211/jpp/61.07.0017] [PMID: 19589240]
[34]
Bhat S, Rather S, Iqbal A, Qureshi H, Islam N. Immunomodulators for curtailing COVID-19: A positive approach. J Drug Deliv Ther 2020; 10(3-s): 286-94.
[http://dx.doi.org/10.22270/jddt.v10i3-s.4085]
[35]
Gautam S, Gautam A, Chhetri S, Bhattarai U. Immunity against COVID-19: Potential role of Ayush Kwath. J Ayurveda Integr Med 2020.
[http://dx.doi.org/10.1016/j.jaim.2020.08.003] [PMID: 32837101]
[36]
Khan K. Roles of Emblica officinalis in medicine-A review. Bot Res Int 2009; 2(4): 218-28.
[37]
Dasaroju S, Gottumukkala K. Current trends in the research of emblica officinalis (Amla): a pharmacological perspective. Int J Pharm Sci Rev Res 2014; 24(2): 150-9.
[38]
Hasan M, Islam M, Islam M. Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: A review. Int Curr Pharm J 2016; 5(2): 14-21.
[http://dx.doi.org/10.3329/icpj.v5i2.26441]
[39]
Sai Ram M, Neetu D, Yogesh B, et al. Cyto-protective and immunomodulating properties of Amla (Emblica officinalis) on lymphocytes: an in-vitro study. J Ethnopharmacol 2002; 81(1): 5-10.
[http://dx.doi.org/10.1016/S0378-8741(01)00421-4] [PMID: 12020921]
[40]
Kaleem QM, Akhtar M, Awais MM, et al. Studies on Emblica officinalis derived tannins for their immunostimulatory and protective activities against coccidiosis in industrial broiler chickens. ScientificWorldJournal 2014; 2014378473
[http://dx.doi.org/10.1155/2014/378473] [PMID: 24578631]
[41]
Mittal B, Chand T. Global care through ayurveda in pandemic of COVID-19. Int J Health Sci Res 2020; 10(6): 165-72.
[42]
Gaur L, Singh S, Gaur S, Bornare S, Chavan A, Kumar S, et al. A basic information, cultivation and medicinal use of Tinospora cordifolia. Popular Kheti 2014; 2(3): 188-92.
[43]
Sinha K, Mishra N, Singh J, Khanuja S. Tinospora cordifolia (Guduchi): A reservoir plant for therapeutic applications: A review. Indian J Tradit Knowl 2004; 3(3): 257-70.
[44]
Tiwari P, Nayak P, Prusty S, Sahu P. Phytochemistry and pharmacology of Tinospora cordifolia: A review. Sys Rev Pharm 2018; 9(1): 70-8.
[http://dx.doi.org/10.5530/srp.2018.1.14]
[45]
Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005; 96(3): 445-9.
[http://dx.doi.org/10.1016/j.jep.2004.09.034] [PMID: 15619563]
[46]
Priyadarsini KI. The chemistry of curcumin: From extraction to therapeutic agent. Molecules 2014; 19(12): 20091-112.
[http://dx.doi.org/10.3390/molecules191220091] [PMID: 25470276]
[47]
Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol 2008; 75(4): 787-809.
[http://dx.doi.org/10.1016/j.bcp.2007.08.016] [PMID: 17900536]
[48]
Momtazi-Borojeni AA, Haftcheshmeh SM, Esmaeili SA, Johnston TP, Abdollahi E, Sahebkar A. Curcumin: A natural modulator of immune cells in systemic lupus erythematosus. Autoimmun Rev 2018; 17(2): 125-35.
[http://dx.doi.org/10.1016/j.autrev.2017.11.016] [PMID: 29180127]
[49]
Abe Y, Hashimoto S, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 1999; 39(1): 41-7.
[http://dx.doi.org/10.1006/phrs.1998.0404] [PMID: 10051376]
[50]
Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. J Surg Res 2000; 89(2): 169-75.
[http://dx.doi.org/10.1006/jsre.2000.5826] [PMID: 10729246]
[51]
Alagawany M, Ashour E, Reda F. Effect of dietary supplementation of garlic (Allium Sativum) and Turmeric (Curcuma Longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbits. Ann Anim Sci 2016; 16(2): 489-505.
[http://dx.doi.org/10.1515/aoas-2015-0079]
[52]
Yadav VS, Mishra KP, Singh DP, Mehrotra S, Singh VK. Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol 2005; 27(3): 485-97.
[http://dx.doi.org/10.1080/08923970500242244] [PMID: 16237958]
[53]
Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 1995; 206(2): 533-40.
[http://dx.doi.org/10.1006/bbrc.1995.1076] [PMID: 7530002]
[54]
Vaghasiya J, Datani M, Nandkumar K, Malaviya S, Jivani N. Comparative evaluation of alcoholic and aqueous extracts of Ocimum sanctum for immunomodulatory activity. Int J Biol Pharmaceut Res 2010; 1(1): 25-9.
[55]
Singh S, Taneja M, Majumdar DK. Biological activities of Ocimum sanctum L. fixed oil--an overview. Indian J Exp Biol 2007; 45(5): 403-12.
[PMID: 17569280]
[56]
Khanna K, Kohli SK, Kaur R, et al. Herbal immune-boosters: Substantial warriors of pandemic COVID-19 battle. Phytomedicine 2021; 85153361
[http://dx.doi.org/10.1016/j.phymed.2020.153361] [PMID: 33485605]
[57]
Sikarwar MS, Patil MB, Shalini S, Vishnu B. Aloe vera: Plant of immortality. Int J Pharm Sci Res 2010; 1(1): 7-10.
[58]
Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules 2008; 13(8): 1599-616.
[http://dx.doi.org/10.3390/molecules13081599] [PMID: 18794775]
[59]
Varma A, Padh H, Shrivastava N. Andrographolide: A new plant-derived antineoplastic entity on horizon. Evid Based Complement Alternat Med 2011; 2011: 1-9.
[http://dx.doi.org/10.1093/ecam/nep135]
[60]
Bopana N, Saxena S. Asparagus racemosus--ethnopharmacological evaluation and conservation needs. J Ethnopharmacol 2007; 110(1): 1-15.
[http://dx.doi.org/10.1016/j.jep.2007.01.001] [PMID: 17240097]
[61]
Sinha K, Mishra N, Singh J, Khanuja S. Tinospora cordifolia: A reservoir plant for therapeutic applications: A review Ind J Tradit Knowl 2004; 3(3): 257-70.
[62]
Halder S, Bharal N, Mediratta PK, Kaur I, Sharma KK. Anti-inflammatory, immunomodulatory and antinociceptive activity of Terminalia arjuna Roxb bark powder in mice and rats. Indian J Exp Biol 2009; 47(7): 577-83.
[PMID: 19761042]
[63]
Singh VK, Dwivedi P, Chaudhary BR, Singh R. Immunomodulatory effect of Gymnema sylvestre (R.Br.) leaf extract: An in-vitro study in rat model. PLoS One 2015; 10(10)e0139631
[http://dx.doi.org/10.1371/journal.pone.0139631] [PMID: 26474420]
[64]
Mungantiwar AA, Nair AM, Shinde UA, et al. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction. J Ethnopharmacol 1999; 65(2): 125-31.
[http://dx.doi.org/10.1016/S0378-8741(98)00153-6] [PMID: 10465652]
[65]
Bhatt P, Pandya K, Sheth N. Camellia sinensis (L): The medicinal beverage: A review. Int J Pharm Sci Rev Res 2010; 3(2): 6-9.
[66]
Ismail S, Asad M. Immunomodulatory activity of Acacia catechu. Indian J Physiol Pharmacol 2009; 53(1): 25-33.
[PMID: 19810573]
[67]
Ghaisas M, Shaikh S, Deshpande A. Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark of Bauhinia variegate Linn. Int J Green Pharm 2009; 3(1): 70.
[http://dx.doi.org/10.4103/0973-8258.49379]
[68]
Smit HF, Kroes BH, van den Berg AJ, et al. Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora. J Ethnopharmacol 2000; 73(1-2): 101-9.
[http://dx.doi.org/10.1016/S0378-8741(00)00268-3] [PMID: 11025145]
[69]
Killestein J, Hoogervorst EL, Reif M, et al. Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis. J Neuroimmunol 2003; 137(1-2): 140-3.
[http://dx.doi.org/10.1016/S0165-5728(03)00045-6] [PMID: 12667658]
[70]
Ganju L, Karan D, Chanda S, Srivastava KK, Sawhney RC, Selvamurthy W. Immunomodulatory effects of agents of plant origin. Biomed Pharmacother 2003; 57(7): 296-300.
[http://dx.doi.org/10.1016/S0753-3322(03)00095-7] [PMID: 14499177]
[71]
Patil S, Naikwade N, Magdum C. Review on phytochemistry and pharmacological aspects of Euphorbia hirta Linn. J Pharmaceut Res and Health Care 2009; 1(1): 113-33.
[72]
Bharani SE, Asad M, Dhamanigi SS, Chandrakala GK. Immunomodulatory activity of methanolic extract of Morus alba Linn. (mulberry) leaves. Pak J Pharm Sci 2010; 23(1): 63-8.
[PMID: 20067869]
[73]
Kobayashi H, de Mejía E. The genus Ardisia: a novel source of health-promoting compounds and phytopharmaceuticals. J Ethnopharmacol 2005; 96(3): 347-54.
[http://dx.doi.org/10.1016/j.jep.2004.09.037] [PMID: 15619551]
[74]
Menin A, Ballarin L. Immunomodulatory molecules in the compound ascidian Botryllus schlosseri: Evidence from conditioned media. J Invertebr Pathol 2008; 99(3): 275-80.
[http://dx.doi.org/10.1016/j.jip.2008.08.001] [PMID: 18768139]
[75]
Jiménez-Medina E, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F. A new extract of the plant Tinospora cordifolia produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation. BMC Cancer 2006; 6(119): 119.
[http://dx.doi.org/10.1186/1471-2407-6-119] [PMID: 16677386]
[76]
Senchina DS, McCann DA, Asp JM, et al. Changes in immunomodulatory properties of Echinacea spp. root infusions and tinctures stored at 4°C for four days. Clin Chim Acta 2005; 355(1-2): 67-82.
[http://dx.doi.org/10.1016/j.cccn.2004.12.013] [PMID: 15820480]
[77]
Yang CM, Cheng HY, Lin TC, Chiang LC, Lin CC. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. J Ethnopharmacol 2007; 110(3): 555-8.
[http://dx.doi.org/10.1016/j.jep.2006.09.039] [PMID: 17113739]
[78]
Serkedjieva J. A Plant Preparation from Geranium sanguineum L. Inhibits influenza virus specific macromolecular synthesis. Biochem Soc Trans 2000; 28(5): A439-9.
[http://dx.doi.org/10.1042/bst028a439]
[79]
Pantev A, Ivancheva S, Staneva L, Serkedjieva J. Biologically active constituents of a polyphenol extract from Geranium sanguineum L. with anti-influenza activity. Z Natforsch C J Biosci 2006; 61(7-8): 508-16.
[http://dx.doi.org/10.1515/znc-2006-7-807] [PMID: 16989309]
[80]
Felipe AM, Rincão VP, Benati FJ, et al. Antiviral effect of Guazuma ulmifolia and Stryphnodendron adstringens on poliovirus and bovine herpesvirus. Biol Pharm Bull 2006; 29(6): 1092-5.
[http://dx.doi.org/10.1248/bpb.29.1092] [PMID: 16754999]
[81]
Edziri H, Mastouri M, Mahjoub M, et al. Antiviral activity of leaves extracts of Marriubium alysson L. J Med Plants Res 2011; 5(3): 360-3.
[82]
Li SY, Chen C, Zhang HQ, et al. Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res 2005; 67(1): 18-23.
[http://dx.doi.org/10.1016/j.antiviral.2005.02.007] [PMID: 15885816]
[83]
Parida MM, Upadhyay C, Pandya G, Jana AM. Inhibitory potential of neem (Azadirachta indica Juss) leaves on dengue virus type-2 replication. J Ethnopharmacol 2002; 79(2): 273-8.
[http://dx.doi.org/10.1016/S0378-8741(01)00395-6] [PMID: 11801392]
[84]
Devi P, Monharan K. Antiviral medicinal plants-An ethnobotanical approach. J Phytol 2009; 1(6): 417-21.
[85]
Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian J Physiol Pharmacol 2005; 49(2): 125-31.
[PMID: 16170979]
[86]
Hudson J, Vimalanathan S. Echinacea-A source of potent antivirals for respiratory virus infections. Pharmaceuticals 2011; 4(7): 1019-31.
[http://dx.doi.org/10.3390/ph4071019]
[87]
Hafidh R, Abdulamir A, Jahanshiri F, Abas F, Bakar F, Sekawi Z. Asia is the mine of natural antiviral products for public health. Open Complement Med J 2009; 1: 58-68.
[88]
Rustem D. Antiherpetic activity of some endemic Hypericum species in Turkey. Afr J Biotechnol 2012; 11(5): 1240-4.
[http://dx.doi.org/10.5897/AJB11.3139]
[89]
Rathore B, Ali Mahdi A, Nath Paul B, Narayan Saxena P, Kumar Das S. Indian herbal medicines: Possible potent therapeutic agents for rheumatoid arthritis. J Clin Biochem Nutr 2007; 41(1): 12-7.
[http://dx.doi.org/10.3164/jcbn.2007002] [PMID: 18392103]
[90]
Shukla S, Bajpai VK, Kim M. Plants as potential sources of natural immunomodulators. Rev Environ Sci Bio 2014; 13(1): 17-33.
[http://dx.doi.org/10.1007/s11157-012-9303-x]
[91]
Jayawardena R, Sooriyaarachchi P, Chourdakis M, Jeewandara C, Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes Metab Syndr 2020; 14(4): 367-82.
[http://dx.doi.org/10.1016/j.dsx.2020.04.015] [PMID: 32334392]
[92]
Acamovic T, Brooker JD. Biochemistry of plant secondary metabolites and their effects in animals. Proc Nutr Soc 2005; 64(3): 403-12.
[http://dx.doi.org/10.1079/PNS2005449] [PMID: 16048675]
[93]
Panyod S, Ho C-T, Sheen LY. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. J Tradit Complement Med 2020; 10(4): 420-7.
[http://dx.doi.org/10.1016/j.jtcme.2020.05.004] [PMID: 32691006]
[94]
Patil A, Kakde MS. Medicinal plant as a natural immunity booster for COVID19- A review. Int J Integr Med 2020; 2(2): 24-7.
[95]
Ganjhu RK, Mudgal PP, Maity H, et al. Herbal plants and plant preparations as remedial approach for viral diseases. Virusdisease 2015; 26(4): 225-36.
[http://dx.doi.org/10.1007/s13337-015-0276-6] [PMID: 26645032]
[96]
Singh NA, Kumar P, Jyoti Kumar N. Spices and herbs: Potential antiviral preventives and immunity boosters during COVID‐19. Phytother Res 2021; 26: 1-13.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy