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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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General Review Article

The Role of Stem Cells in the Therapy of Stroke

Author(s): Maria Ejma , Natalia Madetko , Anna Brzecka *, Piotr Alster , Sławomir Budrewicz , Magdalena Koszewicz, Marta Misiuk-Hojło, Irina K. Tomilova , Siva G. Somasundaram and Cecil E. Kirkland

Volume 20, Issue 3, 2022

Page: [630 - 647] Pages: 18

DOI: 10.2174/1570159X19666210806163352

Price: $65

Abstract

Background: Stroke is a major challenge in neurology due to its multifactorial genesis and irreversible consequences. Processes of endogenous post-stroke neurogenesis, although insufficient, may indicate possible direction of future therapy. Multiple research considers stem-cell-based approaches in order to maximize neuroregeneration and minimize post-stroke deficits.

Objective: Aim of this study is to review current literature considering post-stroke stem-cell- based therapy and possibilities of inducing neuroregeneration after brain vascular damage.

Methods: Papers included in this article were obtained from PubMed and MEDLINE databases. The following medical subject headings (MeSH) were used: “stem cell therapy”, “post-stroke neurogenesis”, “stem-cells stroke”, “stroke neurogenesis”, “stroke stem cells”, “stroke”, “cell therapy”, “neuroregeneration”, “neurogenesis”, “stem-cell human”, “cell therapy in human”. Ultimate inclusion was made after manual review of the obtained reference list.

Results: Attempts of stimulating neuroregeneration after stroke found in current literature include supporting endogenous neurogenesis, different routes of exogenous stem cells supplying and extracellular vesicles used as a method of particle transport.

Conclusion: Although further research in this field is required, post stroke brain recovery supported by exogenous stem cells seems to be promising future therapy revolutionizing modern neurology.

Keywords: Cell therapy, neurogenesis, stroke, stem-cells, extracellular vesicles, central nervous system.

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