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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

维生素 D 通过调节 PI3K/AKT/mTOR 信号通路影响非小细胞肺癌细胞的 Warburg 效应和干细胞维持

卷 22, 期 1, 2022

发表于: 29 July, 2021

页: [86 - 95] 页: 10

弟呕挨: 10.2174/1568009621666210729100300

价格: $65

摘要

背景：非小细胞肺癌 (NSCLC) 是最普遍的肺癌形式，约占所有肺癌病例的 85%，并导致高发病率和死亡率。先前的研究表明，1,25-二羟基维生素-D3（维生素 D）对乳腺癌和前列腺癌具有抗癌活性。 目的：本研究的目的是探讨维生素 D 对 NSCLC 的影响及其潜在机制。 方法：在体外和体内研究了维生素 D 对 NSCLC 细胞干性维持和 Warburg 效应的影响。 结果与讨论：体外实验表明，维生素 D 可抑制 A549 和 NCI-H1975 细胞的糖酵解和干性维持。体外和体内实验均表明维生素 D 减弱了与 Warburg 效应相关的代谢相关酶（GLUT1、LDHA、HK2 和 PKM2）的表达。此外，维生素 D 下调干性相关基因（Oct-4、SOX-2 和 Nanog）的表达以及 PI3K、AKT 和 mTOR 的表达。结论：总体而言，这些发现表明维生素 D 通过 PI3K/AKT/mTOR 信号通路的失活抑制 NSCLC 细胞中的 Warburg 效应和干性维持，从而抑制 NSCLC 的进展。目前的研究表明，维生素 D 是 NSCLC 治疗策略的潜在候选者。

关键词: 1,25-二羟基维生素-D3、非小细胞肺癌、Warburg 效应、癌症干细胞、PI3K/AKT/mTOR、干性维持

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