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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Systematic Review Article

Creatine Supplementation in Type 2 Diabetic Patients: A Systematic Review of Randomized Clinical Trials

Author(s): Marcella Mancini de Sousa, Mariana Tiemi Kishida Nakata, Carlos Eduardo Slateff Baldini, Elizabeth Barbosa de Oliveira-Sales, Mirian Aparecida Boim, Ana Luiza Cabrera Martimbianco* and Edgar Maquigussa

Volume 18, Issue 3, 2022

Published on: 06 January, 2022

Article ID: e120721194709 Pages: 8

DOI: 10.2174/1573399817666210712151737

Price: $65

Abstract

Type 2 Diabetes Mellitus (DM) is the most common form of diabetes. The initial treatment of type 2 DM consists of the adoption of healthy lifestyle habits together with several classes of hypoglycemic agents. However, these medications are not always able to reduce the blood glucose levels in all patients. Therefore, creatine supplementation has emerged as a new putative candidate for type 2 DM treatment. This systematic review aimed to investigate the effects (benefits and harms) of creatine supplementation in patients with type 2 diabetes through a systematic review. The studies were searched in MEDLINE, EMBASE, LILACS, CENTRAL, SPORTDiscus, and CINAHL databases, without date or language restrictions. Methodological quality was assessed using the Cochrane risk-of-bias table. The certainty of the evidence was classified using the Grading of Recommendations Assessment, Development and Evaluation approach. Three randomized controlled trials (RCTs) were included (87 participants). Overall, the methodological quality was classified as unclear to a high risk of bias. Each trial compared creatine supplementation with a different control group (placebo, metformin, and glibenclamide). Creatine supplementation seems to be effective in decreasing glycemic levels and glycosylated hemoglobin concentrations compared to placebo. No difference was observed compared to metformin or glibenclamide with creatine, and all treatments were able to reduce blood glucose levels. No major adverse effects were observed. Based on the low certainty of evidence, creatine supplementation was shown to be a hypoglycemic intervention for patients with type 2 diabetes, without major adverse events reported. However, well- designed RCTs with larger sample sizes and long-term outcomes are needed to support this evidence.

Keywords: Diabetes mellitus, creatine, hypoglycemic agents, glycosylated hemoglobin, metformin, glibenclamide.

[1]
Vijan S. Type 2 diabetes. Ann Intern Med 2019; 171(9): ITC65-80.
[http://dx.doi.org/10.7326/AITC201911050] [PMID: 31683294]
[2]
International Diabetes Federation. Diabetes Atlas 9th 2020. Available from: https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/159-idf-diabetes-atlas-ninth-edition-2019.html [Accessed 26th Set 2020]
[3]
American Diabetes Association. Standards of medical care in diabetes-2015 abridged for primary care providers. Clin Diabetes 2015; 33(2): 97-111.
[http://dx.doi.org/10.2337/diaclin.33.2.97] [PMID: 25897193]
[4]
Garber AJ, Abrahamson MJ, Barzilay JI, et al. Consensus statement by the american association of clinical endocrinologists and american college of endocrinology on the comprehensive type 2 diabetes management algorithm – 2019 executive summary. Endocr Pract 2019; 25(1): 69-100.
[http://dx.doi.org/10.4158/CS-2018-0535] [PMID: 30742570]
[5]
American Diabetes Association. Lifestyle management: Standards of medical care in diabetes-2018. Diabetes Care 2018; 41(Suppl. 1): S38-50.
[http://dx.doi.org/10.2337/dc18-S004] [PMID: 29222375]
[6]
Op ’t Eijnde B, Ursø B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes 2001; 50(1): 18-23.
[http://dx.doi.org/10.2337/diabetes.50.1.18] [PMID: 11147785]
[7]
Valenzuela PL, Morales JS, Emanuele E, Pareja-Galeano H, Lucia A. Supplements with purported effects on muscle mass and strength. Eur J Nutr 2019; 58(8): 2983-3008.
[http://dx.doi.org/10.1007/s00394-018-1882-z] [PMID: 30604177]
[8]
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr 2017; 14: 18.
[http://dx.doi.org/10.1186/s12970-017-0173-z] [PMID: 28615996]
[9]
Sumien N, Shetty RA, Gonzales EB. Creatine, creatine kinase, and aging. Subcell Biochem 2018; 90: 145-68.
[http://dx.doi.org/10.1007/978-981-13-2835-0_6] [PMID: 30779009]
[10]
Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation. Amino Acids 2010; 38(1): 31-44.
[http://dx.doi.org/10.1007/s00726-009-0263-6] [PMID: 19253023]
[11]
Ročić B, Znaor A, Ročić P, Weber D, Vučić Lovrenčić M. Comparison of antihyperglycemic effects of creatine and glibenclamide in type II diabetic patients. Wien Med Wochenschr 2011; 161(21-22): 519-23.
[http://dx.doi.org/10.1007/s10354-011-0905-7] [PMID: 21792527]
[12]
Rocic B, Bajuk NB, Rocic P, Weber DS, Boras J, Lovrencic MV. Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients. Clin Invest Med 2009; 32(6): E322.
[http://dx.doi.org/10.25011/cim.v32i6.10669] [PMID: 20003839]
[13]
Gualano B, DE Salles Painneli V, Roschel H, et al. Creatine in type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Med Sci Sports Exerc 2011; 43(5): 770-8.
[http://dx.doi.org/10.1249/MSS.0b013e3181fcee7d] [PMID: 20881878]
[14]
Higgins JPT, Thomas J, Chandler J, et al. Cochrane Handbook for systematic reviews of interventions version 60 (updated July 2019). Cochrane 2019.
[http://dx.doi.org/10.1002/9781119536604]
[15]
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6(7): e1000097.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[16]
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016; 5(1): 210.
[http://dx.doi.org/10.1186/s13643-016-0384-4] [PMID: 27919275]
[17]
Review Manager (RevMan) [Computer program] Version 53. The Cochrane Collaboration. Copenhagen: The nordic cochrane centre 2014.
[18]
Guyatt GH, Oxman AD, Vist GE, et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336(7650): 924-6.
[http://dx.doi.org/10.1136/bmj.39489.470347.AD] [PMID: 18436948]
[19]
GRADEpro. Tool GD. McMaster University (developed by Evidence Prime, Inc.) 2015.
[20]
Henriksen EJ. Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002; 93(2): 788-96.
[http://dx.doi.org/10.1152/japplphysiol.01219.2001] [PMID: 12133893]
[21]
Wang CC, Fang CC, Lee YH, Yang MT, Chan KH. Effects of 4-week creatine supplementation combined with complex training on muscle damage and sport performance. Nutrients 2018; 10(11): 1640.
[http://dx.doi.org/10.3390/nu10111640] [PMID: 30400221]
[22]
Solis MY, Artioli GG, Gualano B. Potential of creatine in glucose management and diabetes. Nutrients 2021; 13(2): 570.
[http://dx.doi.org/10.3390/nu13020570] [PMID: 33572228]
[23]
Alves CRR, Ferreira JC, de Siqueira-Filho MA, Carvalho CR, Lancha AH Jr, Gualano B. Creatine-induced glucose uptake in type 2 diabetes: A role for AMPK-α? Amino Acids 2012; 43(4): 1803-7.
[http://dx.doi.org/10.1007/s00726-012-1246-6] [PMID: 22349765]
[24]
Papukashvili D, Rcheulishvili N, Deng Y. Beneficial impacto f semicarbazide-sensitive amine oxidase inhibition on the potential cytotoxicity of creatine supplementation in type 2 diabetes mellitus. Molecules 2020; 25(9): 2029.
[http://dx.doi.org/10.3390/molecules25092029] [PMID: 32349282]
[25]
Obata T. Diabetes and semicarbazide-sensitive amine oxidase (SSAO) activity: A review. Life Sci 2006; 79(5): 417-22.
[http://dx.doi.org/10.1016/j.lfs.2006.01.017] [PMID: 16487546]
[26]
Kim HJ, Kim CK, Carpentier A, Poortmans JR. Studies on the safety of creatine supplementation. Amino Acids 2011; 40(5): 1409-18.
[http://dx.doi.org/10.1007/s00726-011-0878-2] [PMID: 21399917]
[27]
Wong MYW, Saad S, Pollock C, Wong MG. Semicarbazide-sensitive amine oxidase and kidney disease. Am J Physiol Renal Physiol 2013; 305(12): F1637-44.
[http://dx.doi.org/10.1152/ajprenal.00416.2013] [PMID: 24173357]
[28]
de Souza E Silva A, Pertille A, Reis Barbosa CG, et al. Effects of creatine supplementation on renal function: A systematic review and meta-analysis. J Ren Nutr 2019; 29(6): 480-9.
[http://dx.doi.org/10.1053/j.jrn.2019.05.004] [PMID: 31375416]
[29]
Benzi G. Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in a sport? Pharmacol Res 2000; 41(3): 255-64.
[http://dx.doi.org/10.1006/phrs.1999.0618] [PMID: 10675277]
[30]
Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: Challenges, progress, and possibilities. Clin J Am Soc Nephrol 2017; 12(12): 2032-45.
[http://dx.doi.org/10.2215/CJN.11491116] [PMID: 28522654]
[31]
Kelly JT, Palmer SC, Wai SN, et al. Healthy dietary patterns and risk of mortality and ESRD in CKD: A meta-analysis of cohort studies. Clin J Am Soc Nephrol 2017; 12(2): 272-9.
[http://dx.doi.org/10.2215/CJN.06190616] [PMID: 27932391]
[32]
Rennie D. CONSORT revised-improving the reporting of randomized trials. JAMA 2001; 285(15): 2006-7.
[http://dx.doi.org/10.1001/jama.285.15.2006] [PMID: 11308440]

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