SARS-CoV-2: Evaluation and Evolution

Title:SARS-CoV-2: Evaluation and Evolution

Volume: 2 Issue: 8

Author(s): Loay Bedda, Fayrouz Mahmoud*, Radwa Elkhateib*, Alyaa Dawoud, Hassan Gamal, Abdallah S. Abdelsattar and Ayman El-Shibiny*

Affiliation:

• University of Science and Technology, Zewail City of Science and Technology, Giza 12578,Egypt

• Faculty of Biology, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried,Germany

• Center for Microbiology and Phage Therapy, Zewail City of Science and Technology, Giza 12578,Egypt

Keywords: SARS-CoV-2 life cycle, COVID-19 human response, 2019-nCoV, mutations, re-assortment, virus-host interaction.

Abstract: The emerging new COVID 2019 pandemic, which started in 2019 in China (Wuhan) and is caused by SARS-CoV-2, raises critical concerns due to high morbidity and mortality. As many patients are infected and the numbers still increase, this may suggest that there are different variants of the virus and some of them are more pathogenic. Besides, the virus is suspected to have various evolutionary pathways since SARS-CoV-2 belongs to the RNA viruses’ family, which is characterized by a high mutation rate. Additionally, it is crucial to understand the life cycle of the virus to be able to urge antiviral studies. Genotyping studies about viruses are also important in order to understand the transmission and evolution of the virus. The genome of SARS-CoV-2 has a furin-like cleavage site in its S protein that may affect its pathogenicity. It was found that insertions and deletions in S protein have an impact on the transmission and fusion of the virus. The single nucleotide polymorphisms (SNP) genotypes are used to track the relationship of virus isolates. Sequence alignment revealed the presence of hundreds of inter-host mutations during person-to-person transmission. Furthermore, genetic recombination provided a second mechanism for virus evolution. In this review, we highlight the life cycle of the virus and methods of virus evolution caused by mutations or recombination of viral genomes

Cite this article as:

Bedda Loay, Mahmoud Fayrouz *, Elkhateib Radwa *, Dawoud Alyaa , Gamal Hassan , Abdelsattar S. Abdallah and El-Shibiny Ayman *, SARS-CoV-2: Evaluation and Evolution, Coronaviruses 2021; 2 (8) : e110821194689 . https://dx.doi.org/10.2174/2666796702666210712104119