Abstract
Abstract: The occurrence of the diabetes happens due to the irregular operation of glucose in the body, which is also known as glucose homeostasis, thus leading to metabolic changes in the body. The two stages whether hypoglycemia or hyperglycemia differentiates diabetes into various categories and brought new innovative management for the new routes of administration of these disease condition. Various bio-nanotechnologies which are coupled with nano particulates, polymers, Liposome, various gold plated and Solid Lipids Particulates regulate the transcellular transport, non specific cellular uptake, and paracellular transport, which leads to oral, transdermal, Pulmonary, buccal, Nasal, specific gene oriented administration to avoid the non patience compliance with the parental routes of administration. Phytochemicals have an emerging strategy for the future prospects of diabetes management.
Keywords: Nano-biotechnology, diabetes, nanoparticles, metabolic disease, treatment, Insulin.
Graphical Abstract
[http://dx.doi.org/10.1002/adhm.201200037] [PMID: 23184741]
[http://dx.doi.org/10.1002/smll.200801403] [PMID: 19226598]
[http://dx.doi.org/10.2174/157341309789378069]
[http://dx.doi.org/10.1016/j.nano.2012.05.005] [PMID: 22640905]
[http://dx.doi.org/10.1002/wnan.1329] [PMID: 25641955]
[http://dx.doi.org/10.2337/dc09-S062]
[http://dx.doi.org/10.1177/14746514070070010301]
[http://dx.doi.org/10.1038/nrm2391] [PMID: 18401346]
[http://dx.doi.org/10.1900/RDS.2007.4.13] [PMID: 17565412]
[http://dx.doi.org/10.1111/j.1600-0757.2006.00193.x] [PMID: 17474930]
[http://dx.doi.org/10.1093/qjmed/hch077] [PMID: 15208433]
[http://dx.doi.org/10.1016/j.snb.2012.04.016]
[http://dx.doi.org/10.1186/1758-5996-2-66] [PMID: 21059246]
[http://dx.doi.org/10.1177/193229680900300323] [PMID: 20144297]
[http://dx.doi.org/10.1177/193229680900300322] [PMID: 20144296]
[http://dx.doi.org/10.1016/j.biomaterials.2011.08.087] [PMID: 21925726]
[http://dx.doi.org/10.1016/j.addr.2008.11.002] [PMID: 19133304]
[http://dx.doi.org/10.1038/nrmicro1840] [PMID: 18345021]
[http://dx.doi.org/10.1186/1745-6215-10-5]
[PMID: 11806489]
[http://dx.doi.org/10.22159/ijcpr.2017v9i1.16615]
[http://dx.doi.org/10.2174/1381612811319270013] [PMID: 23278495]
[http://dx.doi.org/10.1080/02652040500273753]
[http://dx.doi.org/10.1016/j.progpolymsci.2012.04.004]
[http://dx.doi.org/10.1016/S0378-5173(02)00486-6] [PMID: 12433442]
[http://dx.doi.org/10.1002/jps.20520] [PMID: 16565978]
[http://dx.doi.org/10.1016/j.jconrel.2008.08.020] [PMID: 18817821]
[http://dx.doi.org/10.1021/bc800076n] [PMID: 18517235]
[http://dx.doi.org/10.1016/j.nano.2008.01.003] [PMID: 18339584]
[http://dx.doi.org/10.1208/s12249-010-9561-2] [PMID: 21153572]
[http://dx.doi.org/10.1016/j.jconrel.2009.01.011] [PMID: 19331862]
[http://dx.doi.org/10.2174/187221109787158346] [PMID: 19149726]
[http://dx.doi.org/10.1002/mabi.200900223] [PMID: 20034125]
[http://dx.doi.org/10.1016/j.carbpol.2010.10.070]
[http://dx.doi.org/10.1208/s12249-011-9716-9] [PMID: 22033812]
[http://dx.doi.org/10.1016/j.biomaterials.2011.12.038] [PMID: 22243802]
[http://dx.doi.org/10.1016/j.progpolymsci.2011.06.003] [PMID: 22125349]
[http://dx.doi.org/10.1016/j.biomaterials.2010.07.111] [PMID: 20739057]
[http://dx.doi.org/10.1016/j.ijpharm.2010.04.006] [PMID: 20394813]
[http://dx.doi.org/10.1016/j.jconrel.2006.05.013] [PMID: 16859800]
[http://dx.doi.org/10.1177/0883911507088276]
[http://dx.doi.org/10.1016/j.ijpharm.2011.12.055] [PMID: 22248666]
[http://dx.doi.org/10.1016/j.ijpharm.2011.12.038] [PMID: 22227604]
[http://dx.doi.org/10.1124/jpet.109.158147] [PMID: 20053933]
[http://dx.doi.org/10.1016/j.jconrel.2008.04.013] [PMID: 18534704]
[http://dx.doi.org/10.1016/j.jconrel.2007.04.004] [PMID: 17509718]
[http://dx.doi.org/10.1016/j.colsurfb.2012.07.005] [PMID: 23022553]
[http://dx.doi.org/10.1016/j.jconrel.2007.05.019] [PMID: 17707540]
[http://dx.doi.org/10.1016/j.biomaterials.2008.06.019] [PMID: 18620750]
[http://dx.doi.org/10.1016/S0939-6411(03)00145-0] [PMID: 15018971]
[http://dx.doi.org/10.1016/j.ijpharm.2006.05.050] [PMID: 16828246]
[http://dx.doi.org/10.1016/j.actbio.2010.02.007] [PMID: 20144748]
[http://dx.doi.org/10.1023/A:1007696723125] [PMID: 11303955]
[PMID: 19353572]
[http://dx.doi.org/10.2337/dci18-0023] [PMID: 30093549]
[http://dx.doi.org/10.1016/j.jconrel.2006.10.023] [PMID: 17141909]
[http://dx.doi.org/10.1016/S0168-3659(99)00247-3] [PMID: 10699286]
[http://dx.doi.org/10.1016/j.addr.2009.10.004] [PMID: 19919846]
[http://dx.doi.org/10.1016/j.ejps.2010.12.007] [PMID: 21182939]
[http://dx.doi.org/10.1002/anie.200900441] [PMID: 19562807]
[http://dx.doi.org/10.1016/j.biomaterials.2003.09.065] [PMID: 14967522]
[http://dx.doi.org/10.1016/j.carbpol.2013.02.021] [PMID: 23618232]
[http://dx.doi.org/10.2337/diab.37.2.246] [PMID: 3292320]
[http://dx.doi.org/10.1002/(SICI)1097-4636(19991215)47:4<568::AID-JBM14>3.0.CO;2-X] [PMID: 10497293]
[http://dx.doi.org/10.1021/js970124i] [PMID: 9423155]
[http://dx.doi.org/10.1023/A:1007574030674] [PMID: 10955841]
[http://dx.doi.org/10.1016/j.ejps.2008.01.013] [PMID: 18329862]
[http://dx.doi.org/10.1016/j.ejps.2008.12.017] [PMID: 19167488]
[http://dx.doi.org/10.1016/j.ijpharm.2007.08.053] [PMID: 17923347]
[http://dx.doi.org/10.1002/1520-6017(200010)89:10<1253::AIDJPS3>3.0.CO;2-8] [PMID: 10980500]
[http://dx.doi.org/10.1023/A:1007696723125] [PMID: 11303955]
[http://dx.doi.org/10.1016/j.ejps.2004.03.015] [PMID: 15196588]
[http://dx.doi.org/10.1038/nrd1632] [PMID: 15688077]
[PMID: 21822379]
[http://dx.doi.org/10.2337/diacare.13.9.911] [PMID: 2226109]
[PMID: 17717971]
[http://dx.doi.org/10.1016/S0378-5173(98)00408-6] [PMID: 10089294]
[http://dx.doi.org/10.1016/j.ijpharm.2005.01.018] [PMID: 15814248]
[http://dx.doi.org/10.2147/IJN.S38043] [PMID: 23233804]
[http://dx.doi.org/10.1080/10611860701453653] [PMID: 17613660]
[PMID: 18203427]
[http://dx.doi.org/10.1016/0378-5173(94)90214-3]
[http://dx.doi.org/10.1021/js980235x] [PMID: 9950646]
[http://dx.doi.org/10.1016/j.ijpharm.2011.05.061] [PMID: 21645598]
[http://dx.doi.org/10.1081/DDC-100101255] [PMID: 10769790]
[http://dx.doi.org/10.1016/j.procbio.2012.01.018]
[http://dx.doi.org/10.1016/j.addr.2011.08.006] [PMID: 21925556]
[http://dx.doi.org/10.1007/s11095-007-9257-9] [PMID: 17380266]
[http://dx.doi.org/10.2147/IJN.S26650] [PMID: 22419867]
[http://dx.doi.org/10.1016/j.surg.2010.05.013] [PMID: 20633730]
[http://dx.doi.org/10.1016/j.ijpharm.2006.07.026] [PMID: 16935443]
[PMID: 22848162]
[PMID: 18203440]
[http://dx.doi.org/10.1016/j.ejps.2006.12.007] [PMID: 17280820]
[PMID: 22267925]
[PMID: 19618746]
[http://dx.doi.org/10.1002/dmrr.208] [PMID: 11921428]
[http://dx.doi.org/10.1016/0378-5173(89)90316-5]
[http://dx.doi.org/10.1517/17425247.5.9.1047] [PMID: 18754753]
[PMID: 11265586]
[PMID: 12197420]
[http://dx.doi.org/10.1208/pt060243] [PMID: 16353992]
[http://dx.doi.org/10.1016/S0169-409X(98)00054-4] [PMID: 10837708]
[http://dx.doi.org/10.1210/endo.135.6.7988421] [PMID: 7988421]
[http://dx.doi.org/10.1016/j.ijpharm.2004.05.007] [PMID: 15288339]
[http://dx.doi.org/10.1002/jps.20700] [PMID: 16886206]
[http://dx.doi.org/10.1016/j.ijpharm.2005.10.016] [PMID: 16300914]
[http://dx.doi.org/10.1016/j.jconrel.2006.03.011] [PMID: 16707188]
[http://dx.doi.org/10.3109/10717544.2012.746401] [PMID: 23495666]
[http://dx.doi.org/10.1002/jps.20123] [PMID: 15295781]
[PMID: 2651650]
[PMID: 7996435]
[http://dx.doi.org/10.1271/bbb.70.1003] [PMID: 16636470]
[http://dx.doi.org/10.1016/S0378-5173(01)00588-9] [PMID: 11292539]
[PMID: 18488412]
[http://dx.doi.org/10.1080/02652040400000447] [PMID: 15513761]
[http://dx.doi.org/10.1016/j.jconrel.2006.03.014] [PMID: 16730838]
[http://dx.doi.org/10.1208/ps050209] [PMID: 12866936]
[http://dx.doi.org/10.1016/j.jconrel.2008.12.011] [PMID: 19154761]
[http://dx.doi.org/10.1002/bdd.702] [PMID: 20238376]
[http://dx.doi.org/10.1016/S0378-5173(01)00614-7] [PMID: 11337151]
[http://dx.doi.org/10.1016/j.jconrel.2009.05.031] [PMID: 19481577]
[http://dx.doi.org/10.1038/nbt.1504] [PMID: 18997767]
[http://dx.doi.org/10.1016/j.jconrel.2012.05.030] [PMID: 22634072]
[http://dx.doi.org/10.1016/j.jsps.2012.02.001] [PMID: 23960810]
[http://dx.doi.org/10.1016/S0005-2736(02)00453-4] [PMID: 12100989]
[http://dx.doi.org/10.1016/j.domaniend.2012.01.006] [PMID: 22405830]
[http://dx.doi.org/10.1016/j.cellimm.2006.06.004] [PMID: 16860296]
[http://dx.doi.org/10.1016/j.ejps.2011.10.029] [PMID: 22085632]
[http://dx.doi.org/10.1016/j.diabres.2005.08.005] [PMID: 16171885]
[http://dx.doi.org/10.1016/j.tem.2006.02.002] [PMID: 16504534]
[http://dx.doi.org/10.1111/j.1582-4934.2004.tb00471.x] [PMID: 15601575]
[http://dx.doi.org/10.1101/gad.1303605] [PMID: 15905405]
[http://dx.doi.org/10.1111/j.1440-169X.2005.00814.x] [PMID: 16109037]
[http://dx.doi.org/10.1007/s00125-006-0434-x] [PMID: 17019597]
[http://dx.doi.org/10.3109/08860229509037599] [PMID: 7569106]
[http://dx.doi.org/10.1056/NEJM200007273430401] [PMID: 10911004]
[http://dx.doi.org/10.1186/1758-5996-1-4]
[http://dx.doi.org/10.2337/diabetes.52.1.102] [PMID: 12502499]
[http://dx.doi.org/10.1111/j.1463-1326.2008.00969.x] [PMID: 18834431]
[http://dx.doi.org/10.1097/00006676-200410000-00009] [PMID: 15367890]
[http://dx.doi.org/10.1517/14712598.2010.532786] [PMID: 21029027]
[PMID: 21823254]
[http://dx.doi.org/10.1186/1687-9856-2012-28] [PMID: 23098076]
[PMID: 18596953]