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Review Article

PARP抑制剂单药联合联合治疗子宫内膜癌的研究进展

卷 23, 期 2, 2022

发表于: 13 July, 2021

页: [145 - 155] 页: 11

弟呕挨: 10.2174/1389450122666210617111304

价格: $65

摘要

子宫内膜癌是女性生殖系统最常见的三种恶性肿瘤之一。晚期和复发性子宫内膜癌预后较差，缺乏有效的治疗方法。聚（ADP-核糖）聚合酶（PARP）抑制剂已应用于许多不同类型的肿瘤，它们可以选择性地杀死同源重组修复缺陷的肿瘤细胞。子宫内膜癌的特点是同源重组修复基因发生突变；因此，PARP抑制剂在子宫内膜癌病例的超说明书治疗中取得了积极成果。 PARP 抑制剂作为子宫内膜癌的单一疗法和联合疗法的临床试验正在进行中。在这篇综述中，我们以“子宫内膜癌”和“PARP 抑制剂”作为关键词搜索了 PubMed，并在临床试验网站上使用“olaparib”、“rucaparib”、“niraparib”和“talazoparib”作为搜索词来搜索正在进行的试验。文献检索于 2020 年 10 月结束，仅选择了英文出版物。多项研究证实，PARP抑制剂在杀死具有同源重组修复缺陷的肿瘤细胞方面发挥着重要作用。其与免疫检查点抑制剂、PI3K/AKT/mTOR通路抑制剂、细胞周期检查点抑制剂等药物联合使用可改善子宫内膜癌的治疗。

关键词: PARP抑制剂，子宫内膜癌，同源重组缺陷，靶向治疗，联合治疗，免疫检查点抑制剂，PI3K/AKT/mTOR通路抑制剂

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