Abstract
Oxazole-containing compounds have diverse biological activities, such as antimicrobial, anticancer, antitubercular, antiinflammatory, antidiabetic, antiobesity, antimalarial, and antiviral activities, and some of them have been used as drugs for treating diseases. They also play important roles in the synthesis of bioactive natural products, pharmaceuticals and synthetic transformations as well as in materials, catalyst and agriculture fields. Thus, the development of more efficient and facile synthetic approaches to access oxazole compounds has attracted the intensive interest of chemists, and diverse methods for their synthesis have been investigated. Various established methods have been improved and modified, while numerous novel methods have been discovered. This article will summarize considerable studies on the construction of the oxazole skeleton which date back to 2014.
Keywords: Toluenesulfonylmethyl isocyanide, 2-acylamino-ketones, propargylamides, 5-exo-dig cyclization, multisubstituted oxazoles, antiinflammatory.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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