Advancements in the Functionalization of Aryl C-sp² and Alkyl C-sp³ of Toluene Derivatives via C-H Activation

Title:Advancements in the Functionalization of Aryl C-sp² and Alkyl C-sp³ of Toluene Derivatives via C-H Activation

Volume: 25 Issue: 15

Author(s): Kevin George and Sathananthan Kannadasan *

Affiliation:

• Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu,India

Keywords: Toluene, C-H activation, C-C coupling, C-heteroatom bond formation, cross dehydrogenative coupling, directing groups.

Abstract: Toluene and its derivatives have been well established as versatile scaffolds in organic synthesis over the last few decades. This review provides a brief and concise overview of the current status and latest methodologies in the synthetic utility of toluene and its derivatives by exploiting both the alkyl-sp³ and aryl-sp² carbons via C-H activation. The review also explores the effect of various substituents on the toluene derivatives in facilitating different reactions.

Cite this article as:

George Kevin and Kannadasan Sathananthan *, Advancements in the Functionalization of Aryl C-sp² and Alkyl C-sp³ of Toluene Derivatives via C-H Activation, Current Organic Chemistry 2021; 25 (15) . https://dx.doi.org/10.2174/1385272825666210608114300