Phytochemicals as Potential Inhibitors of Advanced Glycation End Products:
Health Aspects and Patent Survey

Annayara   C. F.   Fernandes; Jeane    B.    Melo; Vanize    M.    Genova; Ádina    L.    Santana; Gabriela      Macedo
doi:10.2174/2212798412666210528130001
Abstract

Background: The glycation of proteins and lipids synthesizes the advanced glycation end products (AGEs), i.e., substances that irreversibly damage macromolecules present in tissues and organs, which contribute to the impairment of biological functions. For instance, the accumulation of AGEs induces oxidative stress, the inflammatory responses, and consequently the on set/worsening of diseases, including obesity, asthma, cognitive impairment, and cancer. There is a current demand on natural and low-cost sources of anti-AGE agents. As a result, food phytochemicals presented promising results to inhibit glycation and consequently, the formation of AGEs.
Objective: Here we describe how the AGEs are present in food via Maillard reaction and in organs via natural aging, as well as the effects of AGEs on the worsening of diseases. Also we described the methods used to detect AGEs in samples, and the current findings on the use of phytochemicals (phenolic compounds, phytosterols, carotenoids, terpenes and vitamins) as natural therapeuticals to inhibit health damages via inhibition of AGEs in vitro and in vivo.
Methods: This manuscript reviewed publications available in the PubMed and Science Direct databases dated from the last 20 years on the uses of phytochemicals for the inhibition of AGEs. Recent patents on the use of anti-AGEs drugs were reviewed with the use of Google Advanced Patents database.
Results and Discussion: There is no consensus about which concentration of AGEs in blood serum should not be hazardous to the health of individuals. Food phytochemicals derived from agroindustry wastes, including peanut skins, and the bagasses derived from citrus and grapes are promising anti-AGEs agents via scavenging of free radicals, metal ions, the suppression of metabolic pathways that induces inflammation, the activation of pathways that promote antioxidant defense, and the blocking of AGE connection with the receptor for advanced glycation endproducts (RAGE).
Conclusion: Phytochemicals derived from agroindustry are promising anti-AGEs, which can be included to replace synthetic drugs to inhibit AGE formation, and consequently to act as therapeutical strategy to prevent and treat diseases caused by AGEs, including diabetes, ovarian cancer, osteoporosis, and Alzheimer’s disease.
Keywords: Maillard reaction, advanced glycation end products, biowastes, bioactive compounds, antiglycant, antioxidant.
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Graphical Abstract

[1]
Wu CH, Huang SM, Lin JA, Yen GC. Inhibition of advanced glycation endproduct formation by foodstuffs. Food Funct  2011; 2(5): 224-34.
 [http://dx.doi.org/10.1039/c1fo10026b]

[2]
Hellwig M, Henle T. Baking, ageing, diabetes: A short history of the Maillard reaction. Angew Chem Int Ed Engl  2014; 53(39): 10316-29.
 [http://dx.doi.org/10.1002/anie.201308808]

[3]
Snelson M, Coughlan MT. Dietary advanced glycation end products: digestion, metabolism and modulation of gut microbial ecology. Nutrients  2019; 11(2): 215.
 [http://dx.doi.org/10.3390/nu11020215]

[4]
de Vos LC, Lefrandt JD, Dullaart RPF, Zeebregts CJ, Smit AJ. Advanced glycation end products: an emerging biomarker for adverse outcome in patients with peripheral artery disease. Atherosclerosis  2016; 254: 291-9.
 [http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.012]

[5]
Charrin E, Faes C, Sotiaux A, et al. Receptor for advanced glycation end products antagonism blunts kidney damage in transgenic townes sickle mice. Front Physiol  2019; 10: 880.
 [http://dx.doi.org/10.3389/fphys.2019.00880]

[6]
Jensen LJ, Flyvbjerg A, Bjerre M. Soluble receptor for advanced glycation end product: a biomarker for acute coronary syndrome. BioMed Res Int  2015; 2015: 1-7.
 [http://dx.doi.org/10.1155/2015/815942]

[7]
Băbţan AM, Ilea A, Boşca BA, et al. Advanced glycation end products as biomarkers in systemic diseases: premises and perspectives of salivary advanced glycation end products. Biomarkers Med  2019; 6(13): 479-95.
 [http://dx.doi.org/10.2217/bmm-2018-0448]

[8]
Poulsen MW, Hedegaard RV, Andersen JM, et al. Advanced glycation endproducts in food and their effects on health. Food Chem Toxicol  2013; 60: 10-37.
 [http://dx.doi.org/10.1016/j.fct.2013.06.052]

[9]
Vlassara H, Palace MR. Diabetes and advanced glycation endproducts. J Intern Med  2002; 251(2): 87-101.
 [http://dx.doi.org/10.1046/j.1365-2796.2002.00932.x]

[10]
Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE. Diabetes and advanced glycoxidation end products. Diabetes Care  2006; 29(6): 1420-32.
 [http://dx.doi.org/10.2337/dc05-2096]

[11]
Sadowska-Bartosz I, Bartosz G. Prevention of protein glycation by natural compounds. Molecules  2015; 20(2): 3309-34.
 [http://dx.doi.org/10.3390/molecules20023309]

[12]
Sadowska-Bartosz I, Galiniak S, Bartosz G. Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds. Molecules  2014; 19(4): 4880-96.
 [http://dx.doi.org/10.3390/molecules19044880]

[13]
Abbas G, Al-Harrasi AS, Hussain H, Sattar SA, Choudhary MI. Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells. Int J Phytomed  2016; 8: 533-40.
 [http://dx.doi.org/10.5138/09750185.1924]

[14]
Tabrez S, Al-Shali KZ, Ahmad S. Lycopene powers the inhibition of glycation-induced diabetic nephropathy: a novel approach to halt the AGE-RAGE axis menace. Biofactors  2015; 41(5): 372-81.
 [http://dx.doi.org/10.1002/biof.1238]

[15]
Sobhy R, Zhan F, Mekawi EM, Khalifa I, Liang H, Li B. The noncovalent conjugations of bovine serum albumin with three structurally different phytosterols exerted antiglycation effects: a study with AGEs-inhibition, multispectral, and docking investigations. Biorganic chem  2019; 103478.

[16]
Pubmed. Available from: www.pubmed.com (Accessed on 12.12.2020)

[17]
Science Direct database. 2020. Available from:
          www.sciencedirect.com

[18]
Google Patents Advanced Search. 2020. Available from:
          https://patents.google.com/advanced

[19]
Barbosa JHP, Souza IT, Santana AEG, Goulart MOF. A determinação dos produtos avançados de glicação (AGES) e de lipoxidação (ALES) em alimentos e em sistemas biológicos: avanços, desafios e perspectivas. Quim Nova  2016; 15: 1-13.

[20]
Butterworth-Heinemann Pathophysiology of diabetic retinopathy  2008; 59-70.

[21]
Ahmed N. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res Clin Pract  2005; 67(1): 3-21.
 [http://dx.doi.org/10.1016/j.diabres.2004.09.004]

[22]
Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia  2001; 44(2): 129-46.
 [http://dx.doi.org/10.1007/s001250051591]

[23]
Peppa M, Uribarri J, Valssara H. Glucose, advanced glycation end productos, and diabetes complications: What is new and what works. Clin Diabetes  2003; 21: 186-7.
 [http://dx.doi.org/10.2337/diaclin.21.4.186]

[24]
Wei Q, Liu T, Sun D-W. Advanced glycation end-products (AGEs) in foods and their detecting techniques and methods: a review. T Food Scien & Tech  2018; 82: 32-45.
 [http://dx.doi.org/10.1016/j.tifs.2018.09.020]

[25]
Teodorowicz M, van Neerven J, Savelkoul H. Food processing: the influence of the Maillard reaction on immunogenicity and allergenicity of food proteins. Nutrients  2017; 9(8): 835.
 [http://dx.doi.org/10.3390/nu9080835]

[26]
Akıllıoğlu HG, Gökmen V. Advanced glycation end products (AGEs).  Chem Hazards in Thermally Processed Foods 2019; pp. 121-51.

[27]
Nowotny K, Schröter D, Schreiner M, Grune T. Dietary advanced glycation end products and their relevance for human health. Ageing Res Rev  2018; 47: 55-66.
 [http://dx.doi.org/10.1016/j.arr.2018.06.005]

[28]
Saleh N. What are AGEs and why are they bad for you? 2019.www.mdlinx.com

[29]
Henle T. AGEs in foods: do they play a role in uremia? Kidney Int Suppl  2003; 63(84): S145-7.
 [http://dx.doi.org/10.1046/j.1523-1755.63.s84.16.x]

[30]
Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci  2005; 1043: 461-6.
 [http://dx.doi.org/10.1196/annals.1333.052]

[31]
Illien-Jünger S, Lu Y, Qureshi SA, et al. Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. PLoS One  2015; 10(2): e0116625.
 [http://dx.doi.org/10.1371/journal.pone.0116625]

[32]
Goldberg T, Cai W, Peppa M, et al. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc  2004; 104(8): 1287-91.
 [http://dx.doi.org/10.1016/j.jada.2004.05.214]

[33]
Jajaluddin MA, Saheem A, Inho C, Nashrah AM, Godovikova T, Usma S. Recent advances in detection of AGE s: Immunochemical, bioanalytical and biochemical approaches. IUBMB Life  2015; 62(12): 889-970.

[34]
Sahu PK, Ramisetti NR, Cecchi T, Swain S, Patro CS, Panda J. An overview of experimental designs in HPLC method development and validation. J Pharm Biomed Anal  2018; 147(5): 590-611.
 [http://dx.doi.org/10.1016/j.jpba.2017.05.006]

[35]
Akhter F, Khan MS, Shahab U, Moinuddin AS. Bio‐physical characterization of ribose induced glycation: a mechanistic study on DNA perturbations. J Biol Macromol  2013; 58: 206-10.
 [http://dx.doi.org/10.1016/j.ijbiomac.2013.03.036]

[36]
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature  2001; 414(6865): 813-20.
 [http://dx.doi.org/10.1038/414813a]

[37]
Grau PW. Glicosilación avanzada en la neufropatía diabética y en el envejecimiento. Acta Méd Peruana  2001; 18: 76-82.

[38]
Thornalley PJ, Rabbani N. Detection of oxidized and glycated proteins in clinical samples using mass spectrometry-a user’s perspective. Biochim Biophys Acta  2014; 1840(2): 818-29.
 [http://dx.doi.org/10.1016/j.bbagen.2013.03.025]

[39]
Sharp PS, Rainbow S, Mukherjee S. Serum levels of low molecular weight advanced glycation end products in diabetic subjects. Diabet Med  2003; 20(7): 575-9.
 [http://dx.doi.org/10.1046/j.1464-5491.2003.00973.x]

[40]
Boyer F, Vidot JB, Dubourg AG, Rondeau P, Essop MF, Bourdon E. Oxidative stress and adipocyte biology: focus on the role of AGEs. Oxid Med Cell Longev  2015; 2015534873.
 [http://dx.doi.org/10.1155/2015/534873]

[41]
Halayko AJ, Ghavami S. S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol  2009; 87(10): 743-55.
 [http://dx.doi.org/10.1139/Y09-054]

[42]
Hein GE. Glycation endproducts in osteoporosis-is there a pathophysiologic importance? Clin Chim Acta  2006; 371(1-2): 32-6.
 [http://dx.doi.org/10.1016/j.cca.2006.03.017]

[43]
Viguet-Carrin S, Roux JP, Arlot ME, et al. Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae. Bone  2006; 39(5): 1073-9.
 [http://dx.doi.org/10.1016/j.bone.2006.05.013]

[44]
Yang Q, Wu S, Mao X, Wang W, Tai H. Inhibition effect of curcumin on TNF-α and MMP-13 expression induced by advanced glycation end products in chondrocytes. Pharmacology  2013; 91(1-2): 77-85.
 [http://dx.doi.org/10.1159/000345345]

[45]
Haus JM, Carrithers JA, Trappe SW, Trappe TA.  Collagen, crosslinking, and advanced glycation end products in aging human skeletal muscle. J Appl Physiol (1985)  2007; 103(6): 2068-76.
 [http://dx.doi.org/10.1152/japplphysiol.00670.2007] [PMID: 17901242]

[46]
Semba RD, Bandinelli S, Sun K, Guralnik JM, Ferrucci L. Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study. Eur J Appl Physiol  2010; 108(1): 191-5.
 [http://dx.doi.org/10.1007/s00421-009-1192-5]

[47]
Li J, Liu D, Sun L, Lu Y, Zhang Z. Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective. J Neurol Sci  2012; 317(1-2): 1-5.
 [http://dx.doi.org/10.1016/j.jns.2012.02.018]

[48]
Perrone L, Grant WB. Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer’s disease incidence and prevalence. J Alzheimers Dis  2015; 45(3): 965-79.
 [http://dx.doi.org/10.3233/JAD-140720]

[49]
Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging  2003; 24(2): 197-211.
 [http://dx.doi.org/10.1016/S0197-4580(02)00065-9]

[50]
Outeiro TF, Kontopoulos E, Altmann SM, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease. Science  2007; 317(5837): 516-9.
 [http://dx.doi.org/10.1126/science.1143780]

[51]
Lee D, Park CW, Paik SR, Choi KY. The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process. Biochim Biophys Acta  2009; 1794(3): 421-30.
 [http://dx.doi.org/10.1016/j.bbapap.2008.11.016]

[52]
Padmaraju V, Bhaskar JJ, Prasada Rao UJ, Salimath PV, Rao KS. Role of advanced glycation on aggregation and DNA binding properties of α-synuclein. J Alzheimers Dis  2011; 24(2): 211-21.
 [http://dx.doi.org/10.3233/JAD-2011-101965]

[53]
Li J, Schmidt AM. Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J Biol Chem  1997; 272(26): 16498-506.
 [http://dx.doi.org/10.1074/jbc.272.26.16498]

[54]
Lapolla A, Traldi P, Fedele D. Importance of measuring products of non-enzymatic glycation of proteins. Clin Biochem  2005; 38(2): 103-15.
 [http://dx.doi.org/10.1016/j.clinbiochem.2004.09.007]

[55]
Sajithlal GB, Chandrakasan G. Role of lipid peroxidation products in the formation of advanced glycation end products: An in vitro study on collagen. Proc Indian Acad Sci-Chem  1999; 111(1): 215-29.
 [http://dx.doi.org/10.1002/chin.199930315]

[56]
Lu C, He JC, Cai W, Liu H, Zhu L, Vlassara H. Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells. Proc Natl Acad Sci USA  2004; 101(32): 11767-72.
 [http://dx.doi.org/10.1073/pnas.0401588101]

[57]
Peng X, Ma J, Chen F, Wang M. Naturally occurring inhibitors against the formation of advanced glycation end-products. Food Funct  2011; 2(6): 289-301.
 [http://dx.doi.org/10.1039/c1fo10034c]

[58]
Shinohara M, Thornalley PJ, Giardino I, et al. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest  1998; 101(5): 1142-7.
 [http://dx.doi.org/10.1172/JCI119885]

[59]
Shangari N, O’Brien PJ. The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem Pharmacol  2004; 68(7): 1433-42.
 [http://dx.doi.org/10.1016/j.bcp.2004.06.013]

[60]
Riehl A, Németh J, Angel P, Hess J. The receptor RAGE: Bridging inflammation and cancer. Cell Commun Signal  2009; 7: 12.
 [http://dx.doi.org/10.1186/1478-811X-7-12]

[61]
Logsdon CD, Fuentes MK, Huang EH, Arumugam T. RAGE and RAGE ligands in cancer. Curr Mol Med  2007; 7(8): 777-89.
 [http://dx.doi.org/10.2174/156652407783220697]

[62]
Gebhardt C, Riehl A, Durchdewald M, et al. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med  2008; 205(2): 275-85.
 [http://dx.doi.org/10.1084/jem.20070679]

[63]
Vlassara H, Palace MR. Glycoxidation: the menace of diabetes and aging. Mt Sinai J Med  2003; 70(4): 232-41.

[64]
Forbes JM, Soldatos G, Thomas MC. Below the radar: advanced glycation end products that detour “around the side”. Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes? Clin Biochem Rev  2005; 26(4): 123-34.

[65]
Asgary S, Naderi GA, Shams Ardekani MR, et al. Inhibition of protein glycation by essential oils of branchlets and fruits of Juniperus communis subsp. hemisphaerica. Res Pharm Sci  2014; 9(3): 179-85.

[66]
Maramaldi G, Togni S, Franceschi F, Lati E. Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™). Clin Cosmet Investig Dermatol  2013; 7: 1-9.
 [http://dx.doi.org/10.2147/CCID.S49924]

[67]
Miroliaei M, Aminjafari A, Ślusarczyk S, Nawrot-Hadzik I, Rahimmalek M, Matkowski A. Inhibition of Glycation-induced Cytotoxicity, Protein Glycation, and Activity of Proteolytic Enzymes by Extract from Perovskia atriplicifolia Roots. Pharmacogn Mag  2017; 13(3): S676-83.
 [http://dx.doi.org/10.4103/pm.pm_559_16]

[68]
Yap H-YY, Tan N-H, Ng S-T, Tan C-S, Fung S-Y. Inhibition of protein glycation by tiger milk mushroom [Lignosus rhinocerus (Cooke) Ryvarden] and search for potential anti-diabetic activity-related metabolic pathways by genomic and transcriptomic data mining. Front Pharmacol  2018; 9: 103.
 [http://dx.doi.org/10.3389/fphar.2018.00103]

[69]
Bodiga VL, Eda SR, Veduruvalasa VD, et al. Attenuation of non-enzymatic thermal glycation of bovine serum albumin (BSA) using β-carotene. Int J Biol Macromol  2013; 56: 41-8.
 [http://dx.doi.org/10.1016/j.ijbiomac.2013.01.030]

[70]
Zhao G, Zhang X, Wang H, Chen Z. Beta carotene protects H9c2 cardiomyocytes from advanced glycation end product-induced endoplasmic reticulum stress, apoptosis, and autophagy via the PI3K/Akt/mTOR signaling pathway. Ann Transl Med  2020; 8(10): 647.
 [http://dx.doi.org/10.21037/atm-20-3768]

[71]
Sriramoju S, Goetz K. Molecular docjing interaction between carotenoids and curcumin and RAGE receptor prevents diabetic retinopathy progression. Current Developments in Nutrition  2019; 3(1): 06-044-19.

[72]
Sun P, Cheng KW, He Y, Liu B, Mao X, Chen F. Screening and identification of inhibitors of advanced glycation endproduct formation from microalgal extracts. Food Funct  2018; 9(3): 1683-91.
 [http://dx.doi.org/10.1039/C7FO01840A]

[73]
Vinson JA, Howard TB III. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. J Nutr Biochem  1996; 7: 659-63.
 [http://dx.doi.org/10.1016/S0955-2863(96)00128-3]

[74]
Sukino S, Kotani K, Nirengi S, et al. Dietary intake of vitamin D is related to blood levels of advanced glycation end products during a weight loss program in obese women. J Biomed (Syd)  2016; 1: 1-4.
 [http://dx.doi.org/10.7150/jbm.16497]

[75]
Omidian M, et al. Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: A randomized, placebo-controlled, double blind clinical trial. Diabet & Metab Syndrome. Gale Academic OneFile 2019.
 [http://dx.doi.org/10.1186/s13098-019-0479-x]

[76]
Nikooyeh B, Neyestani TR, Tayebinejad N, et al. Daily intake of vitamin D- or calcium-vitamin D-fortified Persian yogurt drink (doogh) attenuates diabetes-induced oxidative stress: evidence for antioxidative properties of vitamin D. J Hum Nutr Diet  2014; 27(2): 276-83.
 [http://dx.doi.org/10.1111/jhn.12142]

[77]
Iqbal S, Alam MM, Naseem I. Vitamin D prevents glycation of proteins: An in vitro study. FEBS Lett  2016; 590(16): 2725-36.
 [http://dx.doi.org/10.1002/1873-3468.12278]

[78]
Subratty AH, Aukburally N, Jowaheer V, Joonus N. Vitamin C and urea inhibit the formation of advanced glycation end products in vitro. Nutr Food Sci  2010; 40(5): 456-65.
 [http://dx.doi.org/10.1108/00346651011076965]

[79]
Ahmad S, Shahab U, Baig MH, et al. Inhibitory effect of metformin and pyridoxamine in the formation of early, intermediate and advanced glycation end-products. PLoS One  2013; 8(9): e72128.
 [http://dx.doi.org/10.1371/journal.pone.0072128]

[80]
Stracke H, Hammes HP, Werkmann D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes  2001; 109(6): 330-6.
 [http://dx.doi.org/10.1055/s-2001-17399]

[81]
Stirban A, Negrean M, Stratmann B, et al. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care  2006; 29(9): 2064-71.
 [http://dx.doi.org/10.2337/dc06-0531]

[82]
Abdullah KM, Qais FA, Ahmad I, Naseem I. Inhibitory effect of vitamin B3 against glycation and reactive oxygen species production in HSA: An in vitro approach. Arch Biochem Biophys  2017; 627: 21-9.
 [http://dx.doi.org/10.1016/j.abb.2017.06.009]

[83]
Tarwadi KV, Agte VV. Effect of micronutrients on methylglyoxal-mediated in vitro glycation of albumin. Biol Trace Elem Res  2011; 143(2): 717-25.
 [http://dx.doi.org/10.1007/s12011-010-8915-7]

[84]
Nitti M, d’Abramo C, Traverso N, et al. Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. Free Radic Biol Med  2005; 38(7): 846-56.
 [http://dx.doi.org/10.1016/j.freeradbiomed.2004.12.002]

[85]
Pazdro R, Burgess JR. Differential effects of α-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells. Biochim Biophys Acta  2012; 1822(4): 550-6.
 [http://dx.doi.org/10.1016/j.bbadis.2012.01.003]

[86]
Shen Y, Xu Z, Sheng Z. Ability of resveratrol to inhibit advanced glycation end product formation and carbohydrate-hydrolyzing enzyme activity, and to conjugate methylglyoxal. Food Chem  2017; 216: 153-60.
 [http://dx.doi.org/10.1016/j.foodchem.2016.08.034]

[87]
Khan K, Rasheed M, Nadir M, Firdous S, Faizi S. GC-MS & preliminary screening profile of Cordia sinensis leaves - antiglycation, antifungal and insecticidal agents. Nat Prod Res  2019; 1-5.
 [http://dx.doi.org/10.1080/14786419.2019.1641809]

[88]
Dos Santos CHC, Talpo TC, Motta BP, et al. New compounds of Siolmatra brasiliensis and inhibition of in vitro protein glycation damage. Fitoterapia  2019; 133: 109-19.
 [http://dx.doi.org/10.1016/j.fitote.2018.12.023]

[89]
Leopoldini M, Russo N, Toscano M. The molecular basis of natural polyphenolic antioxidants. Food Chem  2011; 125: 288-306.
 [http://dx.doi.org/10.1016/j.foodchem.2010.08.012]

[90]
Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep  2009; 26(8): 1001-43.
 [http://dx.doi.org/10.1039/b802662a]

[91]
Sri Harsha PS, Lavelli V, Scarafoni A. Protective ability of phenolics from white grape vinification by-products against structural damage of bovine serum albumin induced by glycation. Food Chem  2014; 156: 220-6.
 [http://dx.doi.org/10.1016/j.foodchem.2014.01.104]

[92]
Sri Harsha PS, Gardana C, Simonetti P, Spigno G, Lavelli V. Characterization of phenolics, in vitro reducing capacity and anti-glycation activity of red grape skins recovered from winemaking by-products. Bioresour Technol  2013; 140: 263-8.
 [http://dx.doi.org/10.1016/j.biortech.2013.04.092]

[93]
Fernandes ACF, Martins IM, Moreira DKT, Macedo GA. Use of agro‐industrial residues as potent antioxidant, antiglycation agents, and α‐amylase and pancreatic lipase inhibitory activity. J Food Process Preserv  2020; 44(4): e14397.
 [http://dx.doi.org/10.1111/jfpp.14397]

[94]
Li D, Mitsuhashi S, Ubukata M. Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation. Pharm Biol  2012; 50(12): 1531-5.
 [http://dx.doi.org/10.3109/13880209.2012.694106]

[95]
Fernandes ACF, Santana ÁL, Martins IM, Moreira DKT, Macedo JA, Macedo GA. Anti-glycation effect and the α-amylase, lipase, and α-glycosidase inhibition properties of a polyphenolic fraction derived from citrus wastes. Prep Biochem Biotechnol  2020; 50(8): 794-802.
 [http://dx.doi.org/10.1080/10826068.2020.1737941]

[96]
Alam MM, Ahmad I, Naseem I. Inhibitory effect of quercetin in the formation of advance glycation end products of human serum albumin: An in vitro and molecular interaction study. Int J Biol Macromol  2015; 79: 336-43.
 [http://dx.doi.org/10.1016/j.ijbiomac.2015.05.004]

[97]
Sheng Z, Ai B, Zheng L, et al. Inhibitory activities of kaempferol, galangin, carnosic acid and polydatin against glycation and a-amylase and a-glucosidase enzymes. Int J Food Sci Technol  2018; 53: 755-66.
 [http://dx.doi.org/10.1111/ijfs.13579]

[98]
Yang B, Choi E, Shim S. Inhibitory activities of kaempferol against methylglyoxal formation, intermediate of advanced glycation end products. Appl Biol Chem  2017; 60: 57-62.
 [http://dx.doi.org/10.1007/s13765-016-0251-y]

[99]
Zhou Q, Cheng KW, Gong J, Li ETS, Wang M. Apigenin and its methylglyoxal-adduct inhibit advanced glycation end products-induced oxidative stress and inflammation in endothelial cells. Biochem Pharmacol  2019; 166: 231-41.
 [http://dx.doi.org/10.1016/j.bcp.2019.05.027]

[100]
Wu CH, Yen GC. Inhibitory effect of naturally occurring flavonoids on advanced glycation endproducts formation. J Agric Food Chem  2005; 53: 3167-73.
 [http://dx.doi.org/10.1021/jf048550u]

[101]
Zhu D, Wang L, Zhou Q, et al. (+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice. Mol Nutr Food Res  2014; 58(12): 2249-60.
 [http://dx.doi.org/10.1002/mnfr.201400533]

[102]
Yin J, Hedegaard RV, Skibsted LH, Andersen ML. Epicatechin and epigallocatechin gallate inhibit formation of intermediary radicals during heating of lysine and glucose. Food Chem  2014; 146: 48-55.
 [http://dx.doi.org/10.1016/j.foodchem.2013.09.032]

[103]
Kim J, Kim C-S, Moon MK, Kim JS. Epicatechin breaks preformed glycated serum albumin and reverses the retinal accumulation of advanced glycation end products. Eur J Pharmacol  2015; 748: 108-14.
 [http://dx.doi.org/10.1016/j.ejphar.2014.12.010]

[104]
Chen XY, Huang IM. Sun hL, Ho CT, Li S, Lo CY. Anthocyanins in blackcurrant effectively prevent the formation of advanced glycation end products by trapping methylglyoxal. J Funct Foods  2014; 8: 259-68.
 [http://dx.doi.org/10.1016/j.jff.2014.03.025]

[105]
Prior RL, Wu X, Schaich K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem  2005; 53(10): 4290-302.
 [http://dx.doi.org/10.1021/jf0502698]

[106]
Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact  2014; 222: 68-76.
 [http://dx.doi.org/10.1016/j.cbi.2014.08.013]

[107]
Silvan JM, Srey C, Ames JM, del Castillo MD. Glycation is regulated by isoflavones. Food Funct  2014; 5(9): 2036-42.
 [http://dx.doi.org/10.1039/C4FO00260A]

[108]
Wang P, Chen H, Sang S. Trapping methylglyoxal by genistein and its metabolites in mice. Chem Res Toxicol  2016; 29(3): 406-14.
 [http://dx.doi.org/10.1021/acs.chemrestox.5b00516]

[109]
Silván JM, Assar SH, Srey C, Dolores Del Castillo M, Ames JM. Control of the Maillard reaction by ferulic acid. Food Chem  2011; 128(1): 208-13.
 [http://dx.doi.org/10.1016/j.foodchem.2011.03.047]

[110]
Meeprom A, Sompong W, Chan CB, Adisakwattana S. Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro. Molecules  2013; 18(6): 6439-54.
 [http://dx.doi.org/10.3390/molecules18066439]

[111]
Huang SM, Chuang HC, Wu CH, Yen GC. Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. Mol Nutr Food Res  2008; 52(8): 940-9.
 [http://dx.doi.org/10.1002/mnfr.200700360]

[112]
Gugliucci A, Bastos DH, Schulze J, Souza MF. Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. Fitoterapia  2009; 80(6): 339-44.
 [http://dx.doi.org/10.1016/j.fitote.2009.04.007]

[113]
Bains Y, Gugliucci A, Caccavello R. Advanced glycation endproducts form during ovalbumin digestion in the presence of fructose: Inhibition by chlorogenic acid. Fitoterapia  2017; 120: 1-5.
 [http://dx.doi.org/10.1016/j.fitote.2017.05.003]

[114]
Bhattacherjee A, Datta A. Mechanism of antiglycating properties of syringic and chlorogenic acids in in vitro glycation system. Food Res Int  2015; 77: 540-8.
 [http://dx.doi.org/10.1016/j.foodres.2015.08.025]

[115]
Chao CY, Mong MC, Chan KC, Yin MC. Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice. Mol Nutr Food Res  2010; 54(3): 388-95.
 [http://dx.doi.org/10.1002/mnfr.200900087]

[116]
Muthenna P, Akileshwari C, Reddy GB. Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine. Biochem J  2012; 442(1): 221-30.
 [http://dx.doi.org/10.1042/BJ20110846]

[117]
Adisakwattana S, Sompong W, Meeprom A, Ngamukote S, Yibchok-Anun S. Cinnamic acid and its derivatives inhibit fructose-mediated protein glycation. Int J Mol Sci  2012; 13(2): 1778-89.
 [http://dx.doi.org/10.3390/ijms13021778]

[118]
Al-Hussaini H, Kilarkaje N. Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys. Toxicol Appl Pharmacol  2018; 339: 97-109.
 [http://dx.doi.org/10.1016/j.taap.2017.11.025]

[119]
Yilmaz Z, Kalaz EB, Aydin AF, et al. The effect of resveratrol on glycation and oxidation products in plasma and liver of chronic methylglyoxal-treated rats. Pharmacol Rep  2017; 70(3): 584-90.
 [http://dx.doi.org/10.1016/j.pharep.2017.12.005]

[120]
Fernandes ACF, Vieira NC, Santana ÁL, et al. Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages. Food Chem Toxicol  2020; 145111619.
 [http://dx.doi.org/10.1016/j.fct.2020.111619]

[121]
Ramkissoon JS, Mahomoodally MF, Ahmed N, Subratty AH. Antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs. Asian Pac J Trop Med  2013; 6(7): 561-9.
 [http://dx.doi.org/10.1016/S1995-7645(13)60097-8]

[122]
Perera PRD, Ekanayake S, Ranaweera KKDS. Comparison of antyglication and antioxidant potentials and total phenolic contents of decoctions from antidiabetic plants. Procedia Chem  2015; 16: 519-24.
 [http://dx.doi.org/10.1016/j.proche.2015.12.087]

[123]
Khangholi S, Majid FA, Berwary NJ, Ahmad F, Aziz RB. The mechanisms of inhibition of advanced glycation end products formation through polyphenols in hyperglycemic conditions. Planta Med  2016; 82(1-2): 32-45.

[124]
Rahbar S, Synold TW, Termini J, Shuck S. Methods of quantifying methylglyoxal-induced nucleic acid adducts. WO2019152728A1, 2019.

[125]
Lavaud A, Laguerre M, Birtic S, et al. Eutectic extraction solvent and extraction methods by eutectigenesis using this solvent. EP3280276B1 2016.

[126]
Park C, Huo Y, Hu Y, Wang Yu H. Buckwheat shell flavonoid extract and application thereof as AGEs (advanced glycosylation endproducts) inhibitor. CN104825552A 2015.

[127]
Zhang X, He R. Application of cowberry fruit or its extract in preparing medicine or health food for treating, delaying, or relieving AGEs related diseases. CN111032066A, 2018.

[128]
Yanwei L, Yang X. Catalpol is as the purposes of advanced glycosylation end-products inhibitor. CN106176793A, 2016.

[129]
Widgerow AD, Garruto JA. Compositions and methods for ameliorating skin laxity and body contour. US20200069550A1, 2018.

[130]
Park H, Kim YS, Lee SH. Novel Lactococcus lactis strain having advanced glycation end products inhibitory activity effects and use of the same. KR101841021B1, 2017.

[131]
Park H, Kim YS, Lee SH. Novel Bacillus subtilis strain having advanced glycation end product inhibitory activity effects and use of the same. KR101841023B1, 2017.

[132]
Galatsis P, Henderson JL, Kormos BL, et al. Novel imidazo [4,5- c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors. EP3350178A1, 2018.

[133]
Chappie TA, Patel NC, Verhoest PR, et al. 6,7-dihydro-5hpyrazolo[ 5,1-b][1,3]oxazine-2-carboxamide compound. US20190300546A1, 2017.

[134]
Mezentsev AV, Bruskin SA, Soboleva AG, Sobolev VV, Piruzian ES. Pharmacological control of receptor of advanced glycation end-products and its biological effects in psoriasis. Int J Biomed Sci IJBS  2013; 9(3): 112-22.
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DOI https://dx.doi.org/10.2174/2212798412666210528130001	Print ISSN 2772-574X
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