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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

A Convenient Cascade Strategy Towards the Synthesis of Novel Substituted Morpholinopyrimidines and Pyrimidooxazapines

Author(s): Manoj Kumar, Sushil K. Pandey and Deepshikha Gupta*

Volume 19, Issue 2, 2022

Published on: 08 May, 2021

Page: [135 - 143] Pages: 9

DOI: 10.2174/1570178618666210508232550

Price: $65

Abstract

A simple and novel protocol for the facile synthesis of bicyclic hybrid molecular framework of morpholinopyrimidines having six-membered pyrimidine ring fused with the morpholine unit is established. The method has been successfully employed to synthesize both regioisomers of the morpholinopyrimidine derivatives in good to high yields. The strategy is further extended successfully to synthesize bicyclic pyrimidooxazapine derivatives bearing the six-membered aromatic pyrimidine unit fused with seven-membered aliphatic oxazapine fragment.

Keywords: Pyrimidines, morpholine, morpholinopyrimidines, pyrimidooxazapines, oxazapine, heterocycles.

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