Abstract
Abstract: Wound healing is a complex and never-ending process that involves numerous mediators, enzymatic cascades that are directly or indirectly involved in the mechanism. So, it becomes necessary to closely examine critical factors such as gaseous exchange, a moist environment, anti- microbial activity, and exudation liquids' absorption while designing wound dressings. There is a heap of wound dressings available for human use, but they all are way apart from the ideal dressing. The use of biopolymers may be a solution to tackle the difficulties such as combining with growth factors and cells that can trigger wound healing. This article reviews such therapies for wound healing application.
Keywords: Wound healing, hydrogels, skin substitutes, three dimensional printing, hydrocolloids, traumatic tissue.
Graphical Abstract
[http://dx.doi.org/10.1016/j.jid.2016.11.045] [PMID: 28395897]
[http://dx.doi.org/10.1016/j.jdermsci.2004.08.014] [PMID: 15619429]
[http://dx.doi.org/10.1007/978-3-642-60682-3_9]
[http://dx.doi.org/10.1016/j.mpaic.2008.04.009]
[http://dx.doi.org/10.1083/jcb.200708185] [PMID: 18209104]
[http://dx.doi.org/10.3238/arztebl.2008.0558] [PMID: 19629204]
[http://dx.doi.org/10.1128/CMR.14.2.244-269.2001] [PMID: 11292638]
[http://dx.doi.org/10.1089/wound.2013.0506] [PMID: 27134765]
[http://dx.doi.org/10.4103/0970-0358.101321] [PMID: 23162238]
[http://dx.doi.org/10.1155/2019/3706315] [PMID: 31275545]
[http://dx.doi.org/10.4155/ppa.13.18] [PMID: 24237061]
[http://dx.doi.org/10.1016/j.eurpolymj.2018.12.019]
[http://dx.doi.org/10.7603/s40681-015-0022-9] [PMID: 26615540]
[http://dx.doi.org/10.1016/j.jare.2017.01.005] [PMID: 28239493]
[PMID: 6722002]
[http://dx.doi.org/10.3389/fphar.2020.00155] [PMID: 32180720]
[http://dx.doi.org/10.1016/j.jsps.2019.04.010] [PMID: 31297030]
[http://dx.doi.org/10.1007/s40258-015-0202-5] [PMID: 26458938]
[http://dx.doi.org/10.1007/s40204-018-0083-4] [PMID: 29446015]
[http://dx.doi.org/10.12968/bjon.1993.2.7.358] [PMID: 8508017]
[http://dx.doi.org/10.1053/j.ctep.2004.08.006]
[PMID: 7546113]
[http://dx.doi.org/10.3109/02844318709086461] [PMID: 3327160]
[http://dx.doi.org/10.1089/wound.2016.0697] [PMID: 29392094]
[http://dx.doi.org/10.1016/0195-6701(91)90172-5] [PMID: 1674265]
[http://dx.doi.org/10.1111/dsu.12021] [PMID: 23252680]
[http://dx.doi.org/10.3389/fbioe.2016.00082] [PMID: 27843895]
[http://dx.doi.org/10.1016/S0966-7822(97)00014-2]
[http://dx.doi.org/10.1002/pat.1625]
[http://dx.doi.org/10.2147/cwcmr.s50832]
[http://dx.doi.org/10.1016/0305-4179(87)90170-7] [PMID: 3607565]
[http://dx.doi.org/10.1016/j.ajps.2018.09.001] [PMID: 32104439]
[http://dx.doi.org/10.1016/j.burns.2019.04.004] [PMID: 31230798]
[http://dx.doi.org/10.1016/j.msec.2019.109893] [PMID: 31500045]
[http://dx.doi.org/10.1016/j.jiec.2017.06.015]
[http://dx.doi.org/10.1016/j.msec.2017.05.041] [PMID: 28629091]
[http://dx.doi.org/10.1016/j.jare.2013.07.006] [PMID: 25750745]
[http://dx.doi.org/10.1002/pola.23607] [PMID: 19918374]
[http://dx.doi.org/10.1016/j.eurpolymj.2014.11.024]
[http://dx.doi.org/10.1016/j.jconrel.2014.03.052] [PMID: 24746623]
[http://dx.doi.org/10.3389/fchem.2018.00499] [PMID: 30406081]
[http://dx.doi.org/10.1002/smll.201703509] [PMID: 29978547]
[http://dx.doi.org/10.1002/jps.21210] [PMID: 17963217]
[http://dx.doi.org/10.1097/01.prs.0000480012.41411.7c] [PMID: 26910664]
[http://dx.doi.org/10.1089/wound.2014.0586] [PMID: 26858913]
[http://dx.doi.org/10.1208/s12249-014-0237-1] [PMID: 25425388]
[http://dx.doi.org/10.4103/0975-7406.94131] [PMID: 23066206]
[http://dx.doi.org/10.1016/j.carbpol.2008.11.010]
[http://dx.doi.org/10.1016/j.biomaterials.2005.04.012] [PMID: 15919113]
[http://dx.doi.org/10.1021/acsami.8b10064] [PMID: 30204399]
[http://dx.doi.org/10.1134/S0965545X19060105]
[http://dx.doi.org/10.1016/j.carbpol.2019.114988] [PMID: 31320082]
[http://dx.doi.org/10.1016/j.polymertesting.2019.106039]
[http://dx.doi.org/10.1016/j.ijpharm.2018.12.018] [PMID: 30553954]
[http://dx.doi.org/10.1016/j.eurpolymj.2017.01.021]
[http://dx.doi.org/10.2147/IJN.S177256] [PMID: 30237715]
[http://dx.doi.org/10.1111/aor.13369] [PMID: 30311249]
[http://dx.doi.org/10.1021/acs.iecr.8b03122]
[http://dx.doi.org/10.1016/j.ijbiomac.2020.01.067] [PMID: 31931054]
[http://dx.doi.org/10.1111/wrr.12308] [PMID: 26053202]
[http://dx.doi.org/10.1097/01.ASW.0000288217.83128.f3] [PMID: 17762218]
[http://dx.doi.org/10.1016/0305-4179(95)93866-I] [PMID: 7662122]
[http://dx.doi.org/10.1016/S0305-4179(00)00096-6] [PMID: 11226653]
[http://dx.doi.org/10.1097/00000637-199811000-00009] [PMID: 9827953]
[http://dx.doi.org/10.1097/PRS.0b013e3181bf8087] [PMID: 19952629]
[http://dx.doi.org/10.1097/01.prs.0000181692.71901.bd] [PMID: 16217466]
[http://dx.doi.org/10.1097/01.sap.0000100895.41198.27] [PMID: 14745271]
[http://dx.doi.org/10.1016/S0278-2391(98)90805-9] [PMID: 9632330]
[http://dx.doi.org/10.1097/00005537-200206000-00010] [PMID: 12160297]
[http://dx.doi.org/10.1016/S0002-9378(03)00929-3] [PMID: 14710083]
[http://dx.doi.org/10.2165/00128071-200102050-00005] [PMID: 11721649]
[http://dx.doi.org/10.3390/jcm8122083]
[http://dx.doi.org/10.1097/00004630-199701000-00008] [PMID: 9063787]
[http://dx.doi.org/10.1016/S0305-4179(98)00165-X] [PMID: 10323611]
[http://dx.doi.org/10.1038/sj.gt.3302837] [PMID: 16929353]
[http://dx.doi.org/10.1016/S1357-4310(97)01143-X] [PMID: 9449124]
[http://dx.doi.org/10.1016/S0733-8635(05)70412-5] [PMID: 9001858]
[http://dx.doi.org/10.1038/gt.2009.73] [PMID: 19675584]
[http://dx.doi.org/10.1021/ar9800993] [PMID: 10673317]
[http://dx.doi.org/10.1016/S0140-6736(99)90247-7] [PMID: 10437854]
[http://dx.doi.org/10.1007/s10554-016-0981-2] [PMID: 27677762]
[http://dx.doi.org/10.21037/tp.2018.01.02] [PMID: 29770294]
[http://dx.doi.org/10.3389/fbioe.2019.00348] [PMID: 31803738]
[http://dx.doi.org/10.1039/C8TB01757C] [PMID: 32254590]
[http://dx.doi.org/10.1016/j.msec.2019.109873] [PMID: 31500054]