Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review

Title:Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review

Volume: 27 Issue: 34

Author(s): Ashwani Arya, Rubal Chahal, Arun Nanda, Deepak Kaushik, May Bin-Jumah, Md. Habibur Rahman, Mohamed M. Abdel-Daim*Vineet Mittal*

Affiliation:

• Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522,Egypt

• Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana,India

Keywords: RSM (Response Surface Methodology), phytoconstituents, CCD (Central Composite Design), BBD (Box Behnken Design), ultrasound, optimization, extraction.

Abstract:

Background: Extraction is the foremost step to isolate the natural constituents from a medicinal plant and leads the process of development of herbal formulation from bench to bed.

Introduction: In the field of extraction, the optimization approach helps in achieving better yield and quality where a response of concern is determined or influenced by various variables. This review aimed at congregating the application of different statistical designs (CCD/BBD) to optimize the Ultrasound assisted extraction (UAE) parameters for the recovery of various plant actives belonging to different categories.

Methodology: The literature published during the last decade in the various reputed databases (Web of Science, Pubmed, Scopus) was reviewed and compiled to reveal the role of response surface methodology in optimizing the influential parameters involved in the ultrasound assisted extraction of herbs.

Conclusion: From the present investigations, it can be concluded that the different variables, such as sonication power, temperature, time, solute to solvent ratio are generally optimized in UAE of herbs. Moreover, it has also been evidenced from the review of published data that the flavonoids/phenolic acids (>50%) leads the race for the extraction of plants using sound waves. It can be said that the statistically designed UAE has a vast prospective in bringing about a green mutiny in the herbal drug industry and the modeling of various parameters shall be able to absolutely build up a complete drug innovation course (bench to bed).

Cite this article as:

Arya Ashwani , Chahal Rubal, Nanda Arun , Kaushik Deepak , Bin-Jumah May , Rahman Habibur Md., Abdel-Daim M. Mohamed*, Mittal Vineet *, Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review, Current Pharmaceutical Design 2021; 27 (34) . https://dx.doi.org/10.2174/1381612827666210222114441