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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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Opinion Article

Systems Cytogenomics: Are We Ready Yet?

Author(s): Ivan Y. Iourov*, Svetlana G. Vorsanova and Yuri B. Yurov

Volume 22, Issue 2, 2021

Published on: 19 February, 2021

Page: [75 - 78] Pages: 4

DOI: 10.2174/1389202922666210219112419

Price: $65

Abstract

With the introduction of systems theory to genetics, numerous opportunities for genomic research have been identified. Consequences of DNA sequence variations are systematically evaluated using the network- or pathway-based analysis, a technological basis of systems biology or, more precisely, systems genomics. Despite comprehensive descriptions of advantages offered by systems genomic approaches, pathway-based analysis is uncommon in cytogenetic (cytogenomic) studies, i.e. genome analysis at the chromosomal level. Here, we would like to express our opinion that current cytogenomics benefits from the application of systems biology methodology. Accordingly, systems cytogenomics appears to be a biomedical area requiring more attention than it actually receives.

Keywords: Cytogenomics, chromosome, systems biology, pathway, genome, DNA sequence.

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