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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

An Improved and Suitable Method for Large Scale Production of α-Monochlorocyclodecanone

Author(s): Wenhua Ou, Ruolin Wang, Ruonan Liu and Hong Huang*

Volume 19, Issue 5, 2022

Published on: 17 February, 2021

Page: [418 - 421] Pages: 4

DOI: 10.2174/1570178618666210217121023

Price: $65

Abstract

α-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5- dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with a nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, a simple separation method, and an environment-friendly process. Additionally, the current synthesis provided an ideal approach for large-scale production.

Keywords: α-Monochlorocyclododecanone, synthesis, cyclododecane, DCDMH, environment-friendly procedure, large-scale production.

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