Salvia miltiorrhiza in Anti-diabetic Angiopathy

Title:Salvia miltiorrhiza in Anti-diabetic Angiopathy

Volume: 14

Author(s): Zequn Yin, Xuerui Wang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan*Jihong Han*

Affiliation:

• Department of Pharmacological Sciences, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei,China

• Department of Pharmacological Sciences, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei,China

Keywords: Salvia miltiorrhiza, danshen, diabetic angiopathy, bioactive components, endothelial, oxidative stress, inflammation, metabolism.

Abstract: Salvia miltiorrhiza, a traditional Chinese medicine, also named Danshen in China, is widely used for the treatment of cardiovascular disease. It demonstrates multiple biological functions, such as anti-oxidative stress, anti-inflammation and anti-thrombosis. Diabetic angiopathy is one of the diabetic complications with macro- and microangiopathy. Macroangiopathy mainly occurs in arteries, while the microangiopathy mainly includes diabetic retinopathy and nephropathy. Many factors associated with diabetes, such as metabolic abnormalities and oxidative stress, can induce vascular lesions. These factors promote the accumulation of lipids as well as inflammatory cytokines, increase the production of extracellular cell-matrix, and impair endothelium functions, thereby leading to vascular dysfunction. This review attempts to summarize the progress of the studies of Salvia miltiorrhiza on diabetic angiopathy, including improving endothelial function, anti- oxidative stress, reducing the risk of vascular blockage, inhibiting inflammation as well as regulating lipid metabolism. We also summarize the pharmacological activity of bioactive components in Salvia miltiorrhiza and the delivery systems. We made the conclusion that Salvia miltiorrhiza can be used as a potential auxiliary drug for the treatment of diabetic angiopathy.

Cite this article as:

Yin Zequn , Wang Xuerui , Yang Xiaoxiao , Chen Yuanli , Duan Yajun *, Han Jihong *, Salvia miltiorrhiza in Anti-diabetic Angiopathy, Current Molecular Pharmacology 2021; 14 (6) : e301221190182 . https://dx.doi.org/10.2174/1874467214999210111222918