Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119

Title:Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119

Volume: 14 Issue: 4

Author(s): Parmissa Randhawa, Aeli P. Olson, Shaohuang Chen, Kaley Lexi Gower-Fry, Cornelia Hoehr*, Jonathan W. Engle*, Caterina F. Ramogida*Valery Radchenko*

Affiliation:

• Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada

• Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI,United States

• Department of Chemistry, Simon Fraser University, Burnaby, BC,Canada

• Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada

Keywords: Targeted radionuclide therapy (TRT), auger electrons, mercury-197 (¹⁹⁷Hg), antimony-119 (¹¹⁹Sb), production, radiochemicalseparation, coordination, imaging, dosimetry.

Abstract: Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (¹¹⁹Sb) and mercury-197 (¹⁹⁷Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.

Cite this article as:

Randhawa Parmissa , Olson P. Aeli , Chen Shaohuang , Gower-Fry Lexi Kaley , Hoehr Cornelia *, Engle W. Jonathan *, Ramogida F. Caterina *, Radchenko Valery *, Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471014999210111201630